EA201800067A1 - Полисахаридные вакцинные препараты и способ промышленного получения бактериальных полисахаридов - Google Patents
Полисахаридные вакцинные препараты и способ промышленного получения бактериальных полисахаридовInfo
- Publication number
- EA201800067A1 EA201800067A1 EA201800067A EA201800067A EA201800067A1 EA 201800067 A1 EA201800067 A1 EA 201800067A1 EA 201800067 A EA201800067 A EA 201800067A EA 201800067 A EA201800067 A EA 201800067A EA 201800067 A1 EA201800067 A1 EA 201800067A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- neisseria meningitidis
- meningitididis
- vaccine
- polysaccharides
- neisseria
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Представленное изобретение относится к области комбинированных вакцинных композиций, которые являются эффективными против всех форм менингококковых заболеваний, а также брюшного тифа. Вакцинные препараты содержат антигены из капсульных полисахаридов Neisseria meningitidis A, Neisseria meningitidis C, Neisseria meningitidis Y, Neisseria meningitidis W135, Neisseria meningitidis X, Vi капсульного полисахарида Salmonella typhi (ViPs) или капсульных ViPs, конъюгированных с белком-носителем столбнячного анатоксина (ViPs-TT). Данное изобретение также относится к усовершенствованным способам, особенно к использованию улучшенной питательной среды и улучшенного способа последующей обработки и промышленной очистки капсульных полисахаридов. Вакцина не содержит какого-либо животного компонента или спирта и полностью соответствует религиозным чувствам различных этнических групп. Композиция является высокоэффективной и стабильной, еще и экономически эффективной и доступной, особенно для стран с низким и средним уровнем дохода и стран с низким доходом.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3426CH2015 | 2015-07-04 | ||
PCT/IN2016/050218 WO2017006349A1 (en) | 2015-07-04 | 2016-07-04 | Polysaccharide vaccine formulations and processes for industrial production of bacterial polysaccharides |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201800067A1 true EA201800067A1 (ru) | 2018-11-30 |
EA039487B1 EA039487B1 (ru) | 2022-02-01 |
Family
ID=57686117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201800067A EA039487B1 (ru) | 2015-07-04 | 2016-07-04 | Комбинированные полисахаридные вакцинные композиции и способ получения бактериальных капсульных полисахаридов |
Country Status (7)
Country | Link |
---|---|
US (1) | US10543266B2 (ru) |
EP (1) | EP3316903A4 (ru) |
AU (2) | AU2016290233A1 (ru) |
EA (1) | EA039487B1 (ru) |
MY (1) | MY183392A (ru) |
WO (1) | WO2017006349A1 (ru) |
ZA (1) | ZA201800398B (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2019002489A (es) | 2016-09-02 | 2019-10-21 | Sanofi Pasteur Inc | Vacuna contra neisseria meningitidis. |
BR112019022868A2 (pt) | 2017-05-05 | 2020-05-19 | Serum Institute Of India Private Limited | método para remoção de impurezas de preparações à base de polissacarídeo capsular bacteriano |
RU2019140344A (ru) * | 2017-05-17 | 2021-06-17 | Мсд Веллком Траст Хиллеман Лабораторис Пвт. Лтд. | Получение бактериальных полисахаридов |
KR20200021933A (ko) * | 2017-06-27 | 2020-03-02 | 엠에스디 웰컴 트러스트 힐레맨 랩스 피브이티. 리미티드 | 나이세리아 메닌지티디스 혈청군 x 캡슐 다당류의 급속 고수율 정제 방법 |
WO2019175900A1 (en) * | 2018-03-16 | 2019-09-19 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Purification of neisseria meningitidis polysaccharides |
JOP20200214A1 (ar) * | 2019-09-03 | 2021-03-03 | Serum Institute Of India Pvt Ltd | تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها |
US20210070890A1 (en) | 2019-09-06 | 2021-03-11 | Serum Institute Of India Private Limited | Method for obtaining purified bacterial polysaccharides |
CN115478033A (zh) * | 2022-10-13 | 2022-12-16 | 艾美卫信生物药业(浙江)有限公司 | 一种脑膜炎球菌发酵培养方法、发酵液、荚膜多糖、应用 |
CN115478034B (zh) * | 2022-10-13 | 2023-04-18 | 艾美卫信生物药业(浙江)有限公司 | 一种脑膜炎球菌发酵培养方法、发酵液、精制多糖、应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7491517B2 (en) | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
MX354103B (es) | 2012-01-30 | 2018-02-13 | Serum Inst India Ltd | Composicion inmunogenica. |
WO2014009971A2 (en) * | 2012-07-07 | 2014-01-16 | Bharat Biotech International Limited | Non-alcoholic vaccine compositions free from animal- origin and process for preparation thereof |
CA2892035C (en) | 2012-11-21 | 2019-11-05 | Serum Institute Of India Ltd. | Production of neisseria meningitidis x capsular polysaccharide |
-
2016
- 2016-07-04 EA EA201800067A patent/EA039487B1/ru unknown
- 2016-07-04 WO PCT/IN2016/050218 patent/WO2017006349A1/en active Application Filing
- 2016-07-04 EP EP16820976.5A patent/EP3316903A4/en active Pending
- 2016-07-04 MY MYPI2018000021A patent/MY183392A/en unknown
- 2016-07-04 US US15/741,669 patent/US10543266B2/en active Active
- 2016-07-04 AU AU2016290233A patent/AU2016290233A1/en not_active Abandoned
-
2018
- 2018-01-19 ZA ZA2018/00398A patent/ZA201800398B/en unknown
-
2022
- 2022-06-03 AU AU2022203878A patent/AU2022203878A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3316903A1 (en) | 2018-05-09 |
EP3316903A4 (en) | 2019-01-09 |
MY183392A (en) | 2021-02-18 |
US20180185465A1 (en) | 2018-07-05 |
EA039487B1 (ru) | 2022-02-01 |
US10543266B2 (en) | 2020-01-28 |
WO2017006349A1 (en) | 2017-01-12 |
ZA201800398B (en) | 2019-07-31 |
AU2016290233A1 (en) | 2018-01-25 |
AU2022203878A1 (en) | 2022-06-23 |
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