EA202091894A1 - Применение 5-фтор-4-(4-фтор-2-метоксифенил)-n-{4-[(s-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина для лечения диффузной в-крупноклеточной лимфомы - Google Patents

Применение 5-фтор-4-(4-фтор-2-метоксифенил)-n-{4-[(s-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина для лечения диффузной в-крупноклеточной лимфомы

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Publication number
EA202091894A1
EA202091894A1 EA202091894A EA202091894A EA202091894A1 EA 202091894 A1 EA202091894 A1 EA 202091894A1 EA 202091894 A EA202091894 A EA 202091894A EA 202091894 A EA202091894 A EA 202091894A EA 202091894 A1 EA202091894 A1 EA 202091894A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fluoro
pyridin
methoxyphenyl
amine
methyl
Prior art date
Application number
EA202091894A
Other languages
English (en)
Inventor
Арне Шольц
Original Assignee
Байер Акциенгезельшафт
Байер Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Акциенгезельшафт, Байер Фарма Акциенгезельшафт filed Critical Байер Акциенгезельшафт
Publication of EA202091894A1 publication Critical patent/EA202091894A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к применению 5-фтор-4-(4-фтор-2-метоксифенил)-N-{4-[(S-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина (соединение A), более предпочтительно (+)5-фтор-4-(4-фтор-2-метоксифенил)-N-{4-[(S-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина (соединение A'), для лечения диффузной В-крупноклеточной лимфомы (DLBCL), в особенности для диффузной В-крупноклеточной лимфомы из В-клеток зародышевого центра и в особенности для диффузной В-крупноклеточной лимфомы, клетки которой имеют амплификацию или транслокацию гена MYC и/или гена BCL2 и/или сверхэкспрессию MYC и/или BCL2.
EA202091894A 2018-02-13 2019-02-12 Применение 5-фтор-4-(4-фтор-2-метоксифенил)-n-{4-[(s-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина для лечения диффузной в-крупноклеточной лимфомы EA202091894A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18156576 2018-02-13
PCT/EP2019/053407 WO2019158517A1 (en) 2018-02-13 2019-02-12 Use of 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-n-{4-[(s-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large b-cell lymphoma

Publications (1)

Publication Number Publication Date
EA202091894A1 true EA202091894A1 (ru) 2020-12-28

Family

ID=61223765

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091894A EA202091894A1 (ru) 2018-02-13 2019-02-12 Применение 5-фтор-4-(4-фтор-2-метоксифенил)-n-{4-[(s-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина для лечения диффузной в-крупноклеточной лимфомы

Country Status (16)

Country Link
US (1) US11701347B2 (ru)
EP (1) EP3752487A1 (ru)
JP (1) JP7280286B2 (ru)
KR (1) KR20200119800A (ru)
CN (1) CN111727183B (ru)
AU (1) AU2019221019B2 (ru)
BR (1) BR112020016389A2 (ru)
CA (1) CA3090843A1 (ru)
CL (1) CL2020002087A1 (ru)
EA (1) EA202091894A1 (ru)
IL (1) IL276437B2 (ru)
JO (1) JOP20200196A1 (ru)
MA (1) MA51820A (ru)
MX (1) MX2020008447A (ru)
SG (1) SG11202006470RA (ru)
WO (1) WO2019158517A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018114798A1 (de) 2016-12-21 2018-06-28 Bayer Aktiengesellschaft Prodrugs von cytotoxischen wirkstoffen mit enzymatisch spaltbaren gruppen
BR112020016389A2 (pt) 2018-02-13 2020-12-15 Bayer Aktiengesellschaft Uso de 5-fluor-4-(4-fluor-2-metoxifenil)-n-{4-[(s-metilsulfonimidoil)metil]piridin-2-il}piridin-2-amina para tratamento de linfoma difuso de células b grandes

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Also Published As

Publication number Publication date
MX2020008447A (es) 2020-09-28
JOP20200196A1 (ar) 2020-08-13
SG11202006470RA (en) 2020-08-28
JP7280286B2 (ja) 2023-05-23
US20210015806A1 (en) 2021-01-21
WO2019158517A1 (en) 2019-08-22
IL276437B2 (en) 2024-03-01
IL276437A (en) 2020-09-30
BR112020016389A2 (pt) 2020-12-15
KR20200119800A (ko) 2020-10-20
CA3090843A1 (en) 2019-08-22
MA51820A (fr) 2021-05-19
IL276437B1 (en) 2023-11-01
JP2021514386A (ja) 2021-06-10
US11701347B2 (en) 2023-07-18
CN111727183B (zh) 2023-12-29
CN111727183A (zh) 2020-09-29
EP3752487A1 (en) 2020-12-23
CL2020002087A1 (es) 2020-12-11
AU2019221019B2 (en) 2024-05-02
AU2019221019A1 (en) 2020-07-23

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