EA202091766A1 - Композиции для диагностики для пэт-визуализации, способ получения композиции для диагностики и ее применение в диагностике - Google Patents
Композиции для диагностики для пэт-визуализации, способ получения композиции для диагностики и ее применение в диагностикеInfo
- Publication number
- EA202091766A1 EA202091766A1 EA202091766A EA202091766A EA202091766A1 EA 202091766 A1 EA202091766 A1 EA 202091766A1 EA 202091766 A EA202091766 A EA 202091766A EA 202091766 A EA202091766 A EA 202091766A EA 202091766 A1 EA202091766 A1 EA 202091766A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diagnostic
- diagnostics
- application
- composition
- diagnostic composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 238000012800 visualization Methods 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 2
- 208000034799 Tauopathies Diseases 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000002600 positron emission tomography Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Abstract
Настоящая заявка относится к композиции для диагностики, включающей a) соединение формулы Ib) этанол, c) воду и d) гидроксикарбоновую кислоту, соль гидроксикарбоновой кислоты или их смесь. Композиция для диагностики может быть использована для селективного выявления нарушений и аномалий, связанных с агрегатами Тау, таких как болезнь Альцгеймера (AD) и другие тауопатии, например, с помощью позитронно-эмиссионной томографии (ПЭТ). Настоящее изобретение также относится к способу получения заявленной композиции для диагностики.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18153327 | 2018-01-24 | ||
PCT/EP2019/051497 WO2019145293A1 (en) | 2018-01-24 | 2019-01-22 | Diagnostic compositions for pet imaging, a method for manufacturing the diagnostic composition and its use in diagnostics |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202091766A1 true EA202091766A1 (ru) | 2021-02-18 |
Family
ID=61192647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091766A EA202091766A1 (ru) | 2018-01-24 | 2019-01-22 | Композиции для диагностики для пэт-визуализации, способ получения композиции для диагностики и ее применение в диагностике |
Country Status (14)
Country | Link |
---|---|
US (1) | US20210047327A1 (ru) |
EP (1) | EP3743115A1 (ru) |
JP (1) | JP7260552B2 (ru) |
KR (1) | KR20200113241A (ru) |
CN (1) | CN111712265B (ru) |
AU (1) | AU2019210976B2 (ru) |
BR (1) | BR112020014594A8 (ru) |
CA (1) | CA3088232A1 (ru) |
EA (1) | EA202091766A1 (ru) |
IL (1) | IL275990B1 (ru) |
MX (1) | MX2020007487A (ru) |
SG (1) | SG11202006233XA (ru) |
TW (1) | TWI808119B (ru) |
WO (1) | WO2019145293A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021512064A (ja) * | 2018-01-24 | 2021-05-13 | エーシー・イミューン・エス・アー | 画像化化合物を調製する新規方法 |
GB202005282D0 (en) * | 2020-04-09 | 2020-05-27 | Blue Earth Diagnostics Ltd | Pharmaceutical Formulations |
CN114835690B (zh) * | 2022-07-04 | 2022-09-27 | 北京先通国际医药科技股份有限公司 | 含化合物i的液体组合物的制备方法、及在心肌灌注pet显像中的用途 |
CN114832118B (zh) * | 2022-07-04 | 2022-09-27 | 北京先通国际医药科技股份有限公司 | 化合物i液体组合物、制备方法及其用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008099800A1 (ja) * | 2007-02-13 | 2008-08-21 | Nihon Medi-Physics Co., Ltd. | 放射性画像診断剤の製造方法 |
CA2703518A1 (en) * | 2007-11-07 | 2009-05-14 | Ge Healthcare Bv | Stabilization of radiopharmaceuticals |
CA2748705C (en) * | 2008-12-31 | 2017-05-02 | Avid Radiopharmaceuticals, Inc. | Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof |
EP2515948A1 (en) * | 2009-12-23 | 2012-10-31 | Piramal Imaging SA | Formulations suitable for pet imaging with hydrophobic pet agents |
KR101851810B1 (ko) * | 2010-04-16 | 2018-04-26 | 에이씨 이뮨 에스.에이. | 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 신규 화합물 |
SI3055308T1 (en) | 2013-10-08 | 2018-03-30 | F. Hoffmann-La Roche Ag | Diazacarbazole derivatives in the form of tau-pet ligands |
US10662193B2 (en) * | 2014-01-21 | 2020-05-26 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins |
CN107198780A (zh) * | 2016-03-18 | 2017-09-26 | 南京江原安迪科正电子研究发展有限公司 | 放射性药物组合物及其制备方法、应用 |
MY196981A (en) * | 2016-07-22 | 2023-05-16 | Ac Immune Sa | Compounds for imaging tau protein aggregates |
US10865207B2 (en) * | 2016-07-22 | 2020-12-15 | Ac Immune S.A. | Compounds for imaging Tau protein aggregates |
WO2018024642A1 (en) * | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
-
2019
- 2019-01-22 MX MX2020007487A patent/MX2020007487A/es unknown
- 2019-01-22 EP EP19700951.7A patent/EP3743115A1/en active Pending
- 2019-01-22 CA CA3088232A patent/CA3088232A1/en active Pending
- 2019-01-22 SG SG11202006233XA patent/SG11202006233XA/en unknown
- 2019-01-22 CN CN201980009350.5A patent/CN111712265B/zh active Active
- 2019-01-22 US US16/964,969 patent/US20210047327A1/en active Pending
- 2019-01-22 JP JP2020540632A patent/JP7260552B2/ja active Active
- 2019-01-22 AU AU2019210976A patent/AU2019210976B2/en active Active
- 2019-01-22 WO PCT/EP2019/051497 patent/WO2019145293A1/en unknown
- 2019-01-22 EA EA202091766A patent/EA202091766A1/ru unknown
- 2019-01-22 BR BR112020014594A patent/BR112020014594A8/pt unknown
- 2019-01-22 IL IL275990A patent/IL275990B1/en unknown
- 2019-01-22 KR KR1020207024336A patent/KR20200113241A/ko not_active Application Discontinuation
- 2019-01-24 TW TW108102784A patent/TWI808119B/zh active
Also Published As
Publication number | Publication date |
---|---|
CN111712265A (zh) | 2020-09-25 |
TWI808119B (zh) | 2023-07-11 |
US20210047327A1 (en) | 2021-02-18 |
BR112020014594A2 (pt) | 2020-12-01 |
AU2019210976A1 (en) | 2020-07-23 |
TW201932108A (zh) | 2019-08-16 |
BR112020014594A8 (pt) | 2022-12-13 |
IL275990B1 (en) | 2024-04-01 |
KR20200113241A (ko) | 2020-10-06 |
MX2020007487A (es) | 2020-09-14 |
JP7260552B2 (ja) | 2023-04-18 |
CN111712265B (zh) | 2024-02-09 |
JP2021512070A (ja) | 2021-05-13 |
AU2019210976B2 (en) | 2024-04-18 |
CA3088232A1 (en) | 2019-08-01 |
EP3743115A1 (en) | 2020-12-02 |
IL275990A (en) | 2020-08-31 |
SG11202006233XA (en) | 2020-08-28 |
WO2019145293A1 (en) | 2019-08-01 |
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