EA202090521A1 - Новые модуляторы рецептора гамма-аминомасляной кислоты типа a против расстройств настроения - Google Patents
Новые модуляторы рецептора гамма-аминомасляной кислоты типа a против расстройств настроенияInfo
- Publication number
- EA202090521A1 EA202090521A1 EA202090521A EA202090521A EA202090521A1 EA 202090521 A1 EA202090521 A1 EA 202090521A1 EA 202090521 A EA202090521 A EA 202090521A EA 202090521 A EA202090521 A EA 202090521A EA 202090521 A1 EA202090521 A1 EA 202090521A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- modulers
- aminobacyric
- type
- mood disorders
- acid receptor
- Prior art date
Links
- 208000019022 Mood disease Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 102000005915 GABA Receptors Human genes 0.000 abstract 1
- 108010005551 GABA Receptors Proteins 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 229940126662 negative allosteric modulator Drugs 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762550826P | 2017-08-28 | 2017-08-28 | |
| PCT/US2018/048339 WO2019046300A1 (en) | 2017-08-28 | 2018-08-28 | NOVEL MODULATORS OF GAMMA-AMINOBUTYRIC ACID RECEPTOR TYPE A FOR MOOD DISORDERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202090521A1 true EA202090521A1 (ru) | 2020-06-10 |
Family
ID=65525999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202090521A EA202090521A1 (ru) | 2017-08-28 | 2018-08-28 | Новые модуляторы рецептора гамма-аминомасляной кислоты типа a против расстройств настроения |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11459320B2 (pt) |
| EP (1) | EP3675845B1 (pt) |
| JP (2) | JP7403050B2 (pt) |
| KR (1) | KR20200044906A (pt) |
| CN (1) | CN111201016A (pt) |
| AU (1) | AU2018323443B2 (pt) |
| BR (1) | BR112020004116A2 (pt) |
| CA (1) | CA3074110A1 (pt) |
| EA (1) | EA202090521A1 (pt) |
| MX (1) | MX2020002196A (pt) |
| WO (1) | WO2019046300A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7403050B2 (ja) | 2017-08-28 | 2023-12-22 | ユニバーシティ オブ メリーランド ボルチモア | 気分障害のための新規ガンマアミノ酪酸型受容体モジュレーター |
| AU2022270411A1 (en) | 2021-05-05 | 2023-11-23 | University College Cardiff Consultants Limited | Heteroaryl compounds useful in the treatment of cognitive disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2227467T1 (sl) * | 2007-12-04 | 2015-03-31 | F. Hoffmann-La Roche Ag | Derivati izoksazolo-piridina |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| US8604062B2 (en) * | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
| US8785435B2 (en) | 2011-10-20 | 2014-07-22 | Hoffmann-La Roche Inc. | Solid forms |
| ES2836905T3 (es) | 2014-03-31 | 2021-06-28 | Univ Maryland | Uso de moduladores negativos de los receptores gaba que contienen subunidades alfa5 como antidepresivos de acción rápida |
| US10363220B2 (en) * | 2015-06-03 | 2019-07-30 | Triastek, Inc. | Compartmented pharmaceutical dosage forms |
| CA2968836A1 (en) * | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| JP7403050B2 (ja) | 2017-08-28 | 2023-12-22 | ユニバーシティ オブ メリーランド ボルチモア | 気分障害のための新規ガンマアミノ酪酸型受容体モジュレーター |
-
2018
- 2018-08-28 JP JP2020512001A patent/JP7403050B2/ja active Active
- 2018-08-28 EP EP18852438.3A patent/EP3675845B1/en active Active
- 2018-08-28 AU AU2018323443A patent/AU2018323443B2/en active Active
- 2018-08-28 US US16/642,445 patent/US11459320B2/en active Active
- 2018-08-28 KR KR1020207008731A patent/KR20200044906A/ko not_active Application Discontinuation
- 2018-08-28 EA EA202090521A patent/EA202090521A1/ru unknown
- 2018-08-28 BR BR112020004116-5A patent/BR112020004116A2/pt unknown
- 2018-08-28 CA CA3074110A patent/CA3074110A1/en active Pending
- 2018-08-28 CN CN201880065653.4A patent/CN111201016A/zh active Pending
- 2018-08-28 MX MX2020002196A patent/MX2020002196A/es unknown
- 2018-08-28 WO PCT/US2018/048339 patent/WO2019046300A1/en unknown
-
2022
- 2022-08-09 US US17/883,734 patent/US11897875B2/en active Active
-
2023
- 2023-08-03 JP JP2023127334A patent/JP2023133571A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019046300A9 (en) | 2020-10-15 |
| AU2018323443A1 (en) | 2020-03-12 |
| MX2020002196A (es) | 2020-09-28 |
| WO2019046300A1 (en) | 2019-03-07 |
| AU2018323443B2 (en) | 2024-09-05 |
| EP3675845A1 (en) | 2020-07-08 |
| JP2023133571A (ja) | 2023-09-22 |
| US11459320B2 (en) | 2022-10-04 |
| CN111201016A (zh) | 2020-05-26 |
| JP7403050B2 (ja) | 2023-12-22 |
| US20200199119A1 (en) | 2020-06-25 |
| US11897875B2 (en) | 2024-02-13 |
| US20220396572A1 (en) | 2022-12-15 |
| EP3675845B1 (en) | 2024-07-17 |
| KR20200044906A (ko) | 2020-04-29 |
| BR112020004116A2 (pt) | 2020-09-01 |
| JP2021500309A (ja) | 2021-01-07 |
| CA3074110A1 (en) | 2019-03-07 |
| EP3675845A4 (en) | 2021-05-05 |
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