EA201991643A1 - Человеческие антитела к токсину гемолизину а s.aureus - Google Patents

Человеческие антитела к токсину гемолизину а s.aureus

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Publication number
EA201991643A1
EA201991643A1 EA201991643A EA201991643A EA201991643A1 EA 201991643 A1 EA201991643 A1 EA 201991643A1 EA 201991643 A EA201991643 A EA 201991643A EA 201991643 A EA201991643 A EA 201991643A EA 201991643 A1 EA201991643 A1 EA 201991643A1
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EA
Eurasian Patent Office
Prior art keywords
antibodies
aureus
toxin
hemolysin
human antibodies
Prior art date
Application number
EA201991643A
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English (en)
Inventor
Алида Коппи
Питер Мэйсон
Уилльям Олсон
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Ридженерон Фармасьютикалз, Инк.
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Application filed by Ридженерон Фармасьютикалз, Инк. filed Critical Ридженерон Фармасьютикалз, Инк.
Publication of EA201991643A1 publication Critical patent/EA201991643A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В настоящем изобретении предложены антитела, которые связываются с токсином гемолизином A Staphylococcus aureus, и к способам их применения. В соответствии с определенными вариантами осуществления антитела представляют собой полностью человеческие антитела, которые связываются с гемолизином A. Антитела по настоящему изобретению пригодны для ингибирования или нейтрализации активности гемолизина A, таким образом обеспечивая средства профилактики или лечения заболевания или нарушения, связанного с гемолизином A, такого как инфекция, вызываемая S.aureus. В некоторых вариантах осуществления антитела по настоящему изобретению используют в лечении по меньшей мере одного симптома или осложнения инфекции, вызываемой S.aureus.
EA201991643A 2017-01-03 2018-01-02 Человеческие антитела к токсину гемолизину а s.aureus EA201991643A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762441786P 2017-01-03 2017-01-03
PCT/US2018/012044 WO2018128973A1 (en) 2017-01-03 2018-01-02 Human antibodies to s. aureus hemolysin a toxin

Publications (1)

Publication Number Publication Date
EA201991643A1 true EA201991643A1 (ru) 2020-01-20

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EA201991643A EA201991643A1 (ru) 2017-01-03 2018-01-02 Человеческие антитела к токсину гемолизину а s.aureus

Country Status (18)

Country Link
US (3) US10463748B2 (ru)
EP (1) EP3565835A1 (ru)
JP (2) JP2020504759A (ru)
KR (1) KR20190101435A (ru)
CN (1) CN110167960B (ru)
AR (1) AR110719A1 (ru)
AU (1) AU2018206531A1 (ru)
BR (1) BR112019013375A2 (ru)
CA (1) CA3048989A1 (ru)
CL (1) CL2019001836A1 (ru)
CO (1) CO2019006902A2 (ru)
EA (1) EA201991643A1 (ru)
IL (1) IL267600A (ru)
MA (1) MA47202A (ru)
MX (1) MX2019007784A (ru)
PH (1) PH12019501425A1 (ru)
TW (2) TW202311284A (ru)
WO (1) WO2018128973A1 (ru)

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CO2019006902A2 (es) 2019-07-31
CN110167960B (zh) 2023-01-13
AR110719A1 (es) 2019-04-24
CA3048989A1 (en) 2018-07-12
AU2018206531A1 (en) 2019-07-25
PH12019501425A1 (en) 2020-06-15
US20210162059A1 (en) 2021-06-03
CN110167960A (zh) 2019-08-23
US10940211B2 (en) 2021-03-09
KR20190101435A (ko) 2019-08-30
JP2023011710A (ja) 2023-01-24
EP3565835A1 (en) 2019-11-13
MX2019007784A (es) 2019-09-06
US20180214569A1 (en) 2018-08-02
MA47202A (fr) 2019-11-13
IL267600A (en) 2019-08-29
JP2020504759A (ja) 2020-02-13
WO2018128973A1 (en) 2018-07-12
US10463748B2 (en) 2019-11-05
TW202311284A (zh) 2023-03-16
US11571482B2 (en) 2023-02-07
TWI781130B (zh) 2022-10-21
BR112019013375A2 (pt) 2020-02-11
CL2019001836A1 (es) 2019-10-04
TW201837054A (zh) 2018-10-16
US20200016275A1 (en) 2020-01-16

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