EA201991643A1 - Человеческие антитела к токсину гемолизину а s.aureus - Google Patents
Человеческие антитела к токсину гемолизину а s.aureusInfo
- Publication number
- EA201991643A1 EA201991643A1 EA201991643A EA201991643A EA201991643A1 EA 201991643 A1 EA201991643 A1 EA 201991643A1 EA 201991643 A EA201991643 A EA 201991643A EA 201991643 A EA201991643 A EA 201991643A EA 201991643 A1 EA201991643 A1 EA 201991643A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- aureus
- toxin
- hemolysin
- human antibodies
- Prior art date
Links
- 239000003053 toxin Substances 0.000 title abstract 2
- 231100000765 toxin Toxicity 0.000 title abstract 2
- 101710147195 Hemolysin A Proteins 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 241000191967 Staphylococcus aureus Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
В настоящем изобретении предложены антитела, которые связываются с токсином гемолизином A Staphylococcus aureus, и к способам их применения. В соответствии с определенными вариантами осуществления антитела представляют собой полностью человеческие антитела, которые связываются с гемолизином A. Антитела по настоящему изобретению пригодны для ингибирования или нейтрализации активности гемолизина A, таким образом обеспечивая средства профилактики или лечения заболевания или нарушения, связанного с гемолизином A, такого как инфекция, вызываемая S.aureus. В некоторых вариантах осуществления антитела по настоящему изобретению используют в лечении по меньшей мере одного симптома или осложнения инфекции, вызываемой S.aureus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762441786P | 2017-01-03 | 2017-01-03 | |
PCT/US2018/012044 WO2018128973A1 (en) | 2017-01-03 | 2018-01-02 | Human antibodies to s. aureus hemolysin a toxin |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201991643A1 true EA201991643A1 (ru) | 2020-01-20 |
Family
ID=61054509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201991643A EA201991643A1 (ru) | 2017-01-03 | 2018-01-02 | Человеческие антитела к токсину гемолизину а s.aureus |
Country Status (18)
Country | Link |
---|---|
US (3) | US10463748B2 (ru) |
EP (1) | EP3565835A1 (ru) |
JP (2) | JP2020504759A (ru) |
KR (1) | KR20190101435A (ru) |
CN (1) | CN110167960B (ru) |
AR (1) | AR110719A1 (ru) |
AU (1) | AU2018206531A1 (ru) |
BR (1) | BR112019013375A2 (ru) |
CA (1) | CA3048989A1 (ru) |
CL (1) | CL2019001836A1 (ru) |
CO (1) | CO2019006902A2 (ru) |
EA (1) | EA201991643A1 (ru) |
IL (1) | IL267600A (ru) |
MA (1) | MA47202A (ru) |
MX (1) | MX2019007784A (ru) |
PH (1) | PH12019501425A1 (ru) |
TW (2) | TW202311284A (ru) |
WO (1) | WO2018128973A1 (ru) |
Families Citing this family (13)
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TW202311284A (zh) | 2017-01-03 | 2023-03-16 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素a毒素之人類抗體 |
WO2020106461A2 (en) * | 2018-11-08 | 2020-05-28 | Celldex Therapeutics, Inc. | Anti-mertk antibodies and methods of use thereof |
CN109400704B (zh) * | 2018-11-14 | 2020-07-21 | 珠海泰诺麦博生物技术有限公司 | 一种抗金黄色葡萄球菌α-溶血素的抗体及其应用 |
US12024556B2 (en) * | 2018-11-21 | 2024-07-02 | Regeneron Pharmaceuticals, Inc. | Anti-Staphylococcus antibodies and uses thereof |
KR20220019755A (ko) | 2019-06-11 | 2022-02-17 | 리제너론 파마슈티칼스 인코포레이티드 | PcrV에 결합하는 항-PcrV 항체, 항-PcrV 항체를 포함하는 조성물, 및 이의 사용 방법 |
CN112538112B (zh) * | 2019-09-20 | 2023-10-27 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其应用 |
KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
CN113444172A (zh) | 2020-03-25 | 2021-09-28 | 兴盟生物医药(苏州)有限公司 | 金黄色葡萄球菌α-毒素特异性抗体及其应用 |
KR20230147616A (ko) * | 2021-01-11 | 2023-10-23 | 스타맵 바이오로직스 (쑤저우) 씨오., 엘티디 | 황색포도상구균 α-독소를 표적으로 하는 항원 결합단백질 및 이의 응용 |
WO2022199527A1 (zh) * | 2021-03-22 | 2022-09-29 | 星济生物(苏州)有限公司 | 靶向肺炎链球菌溶血素的抗原结合蛋白及其用途 |
WO2023208123A1 (zh) * | 2022-04-28 | 2023-11-02 | 珠海泰诺麦博制药股份有限公司 | 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体 |
CN115894674B (zh) * | 2022-12-20 | 2023-07-25 | 厦门润康源生物科技有限公司 | 一种用于检测冠状病毒的抗体及制备方法和应用 |
CN116789814B (zh) * | 2023-06-27 | 2024-03-29 | 重庆原伦生物科技有限公司 | 一种特异性结合金黄色葡萄球菌α-溶血素的抗体及其应用 |
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2017
- 2017-12-29 TW TW111136305A patent/TW202311284A/zh unknown
- 2017-12-29 TW TW106146395A patent/TWI781130B/zh not_active IP Right Cessation
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2018
- 2018-01-02 BR BR112019013375-5A patent/BR112019013375A2/pt unknown
- 2018-01-02 EP EP18701825.4A patent/EP3565835A1/en active Pending
- 2018-01-02 MX MX2019007784A patent/MX2019007784A/es unknown
- 2018-01-02 CN CN201880005378.7A patent/CN110167960B/zh active Active
- 2018-01-02 AU AU2018206531A patent/AU2018206531A1/en not_active Abandoned
- 2018-01-02 WO PCT/US2018/012044 patent/WO2018128973A1/en unknown
- 2018-01-02 JP JP2019536141A patent/JP2020504759A/ja active Pending
- 2018-01-02 US US15/860,174 patent/US10463748B2/en active Active
- 2018-01-02 EA EA201991643A patent/EA201991643A1/ru unknown
- 2018-01-02 CA CA3048989A patent/CA3048989A1/en active Pending
- 2018-01-02 KR KR1020197022441A patent/KR20190101435A/ko active Search and Examination
- 2018-01-02 MA MA047202A patent/MA47202A/fr unknown
- 2018-01-03 AR ARP180100006A patent/AR110719A1/es unknown
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2019
- 2019-06-20 PH PH12019501425A patent/PH12019501425A1/en unknown
- 2019-06-24 IL IL267600A patent/IL267600A/en unknown
- 2019-06-27 CO CONC2019/0006902A patent/CO2019006902A2/es unknown
- 2019-07-02 CL CL2019001836A patent/CL2019001836A1/es unknown
- 2019-09-19 US US16/575,755 patent/US10940211B2/en active Active
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2021
- 2021-01-27 US US17/159,920 patent/US11571482B2/en active Active
-
2022
- 2022-10-25 JP JP2022170270A patent/JP2023011710A/ja active Pending
Also Published As
Publication number | Publication date |
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CA3048989A1 (en) | 2018-07-12 |
US20200016275A1 (en) | 2020-01-16 |
KR20190101435A (ko) | 2019-08-30 |
CO2019006902A2 (es) | 2019-07-31 |
MA47202A (fr) | 2019-11-13 |
US11571482B2 (en) | 2023-02-07 |
AU2018206531A1 (en) | 2019-07-25 |
US20210162059A1 (en) | 2021-06-03 |
JP2020504759A (ja) | 2020-02-13 |
TWI781130B (zh) | 2022-10-21 |
AR110719A1 (es) | 2019-04-24 |
CN110167960B (zh) | 2023-01-13 |
US10463748B2 (en) | 2019-11-05 |
TW201837054A (zh) | 2018-10-16 |
WO2018128973A1 (en) | 2018-07-12 |
US10940211B2 (en) | 2021-03-09 |
CN110167960A (zh) | 2019-08-23 |
MX2019007784A (es) | 2019-09-06 |
US20180214569A1 (en) | 2018-08-02 |
PH12019501425A1 (en) | 2020-06-15 |
BR112019013375A2 (pt) | 2020-02-11 |
CL2019001836A1 (es) | 2019-10-04 |
EP3565835A1 (en) | 2019-11-13 |
JP2023011710A (ja) | 2023-01-24 |
IL267600A (en) | 2019-08-29 |
TW202311284A (zh) | 2023-03-16 |
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