AR110719A1 - Anticuerpos humanos a la toxina hemolisina a de s. aureus - Google Patents
Anticuerpos humanos a la toxina hemolisina a de s. aureusInfo
- Publication number
- AR110719A1 AR110719A1 ARP180100006A ARP180100006A AR110719A1 AR 110719 A1 AR110719 A1 AR 110719A1 AR P180100006 A ARP180100006 A AR P180100006A AR P180100006 A ARP180100006 A AR P180100006A AR 110719 A1 AR110719 A1 AR 110719A1
- Authority
- AR
- Argentina
- Prior art keywords
- antigen
- binding fragment
- aureus
- hemolysin
- seq
- Prior art date
Links
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 101710147195 Hemolysin A Proteins 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En algunas modalidades, los anticuerpos se utilizan para tratar al menos un síntoma o complicación de una infección de S. aureus. Reivindicación 2: Un anticuerpo humano aislado o el fragmento de unión al antígeno de este que se une específicamente a hemolisina A, en donde el anticuerpo o el fragmento de unión al antígeno comprende tres regiones determinantes de complementariedad de cadena pesada (CDR) (HCDR1, HCDR2 y HCDR3) contenidas dentro de cualquiera de las secuencias de región variable de cadena pesada (HCVR) seleccionadas del grupo que consiste en las SEQ ID Nº 2, 22, 42, 62, 82, 102, 122, 142, 162, 182, 202, 222, 242, 262 y 282; y tres CDR de cadena ligera (LCDR1, LCDR2 y LCDR3) contenidas dentro de cualquiera de las secuencias de región variable de cadena ligera (LCVR) que se seleccionan del grupo que consiste en SEQ ID Nº 10, 30, 50, 70, 90, 110, 130, 150, 170, 190, 210, 230, 250 y 270. Reivindicación 15: Una composición farmacéutica que comprende un anticuerpo humano aislado o un fragmento de unión al antígeno de este que se une a hemolisina A de acuerdo con cualquiera de las reivindicaciones 1 - 11 y 13, y un portador o diluyente farmacéuticamente aceptable; y, opcionalmente, uno o más agentes terapéuticos adicionales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762441786P | 2017-01-03 | 2017-01-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR110719A1 true AR110719A1 (es) | 2019-04-24 |
Family
ID=61054509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180100006A AR110719A1 (es) | 2017-01-03 | 2018-01-03 | Anticuerpos humanos a la toxina hemolisina a de s. aureus |
Country Status (18)
Country | Link |
---|---|
US (3) | US10463748B2 (es) |
EP (1) | EP3565835A1 (es) |
JP (2) | JP2020504759A (es) |
KR (1) | KR20190101435A (es) |
CN (1) | CN110167960B (es) |
AR (1) | AR110719A1 (es) |
AU (1) | AU2018206531A1 (es) |
BR (1) | BR112019013375A2 (es) |
CA (1) | CA3048989A1 (es) |
CL (1) | CL2019001836A1 (es) |
CO (1) | CO2019006902A2 (es) |
EA (1) | EA201991643A1 (es) |
IL (1) | IL267600A (es) |
MA (1) | MA47202A (es) |
MX (1) | MX2019007784A (es) |
PH (1) | PH12019501425A1 (es) |
TW (2) | TWI781130B (es) |
WO (1) | WO2018128973A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI781130B (zh) | 2017-01-03 | 2022-10-21 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素a毒素之人類抗體 |
WO2020106461A2 (en) * | 2018-11-08 | 2020-05-28 | Celldex Therapeutics, Inc. | Anti-mertk antibodies and methods of use thereof |
CN109400704B (zh) * | 2018-11-14 | 2020-07-21 | 珠海泰诺麦博生物技术有限公司 | 一种抗金黄色葡萄球菌α-溶血素的抗体及其应用 |
CN112867732A (zh) | 2018-11-21 | 2021-05-28 | 瑞泽恩制药公司 | 抗葡萄球菌抗体和其用途 |
AU2020292283A1 (en) | 2019-06-11 | 2021-12-23 | Regeneron Pharmaceuticals, Inc. | Anti-PcrV antibodies that bind PcrV, compositions comprising anti-PcrV antibodies, and methods of use thereof |
CN112538112B (zh) * | 2019-09-20 | 2023-10-27 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其应用 |
KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
CN113444171A (zh) * | 2020-03-25 | 2021-09-28 | 兴盟生物医药(苏州)有限公司 | 金黄色葡萄球菌α-毒素特异性抗体及其应用 |
WO2022148480A1 (zh) * | 2021-01-11 | 2022-07-14 | 星济生物(苏州)有限公司 | 靶向金黄色葡萄球菌α-毒素的抗原结合蛋白及其应用 |
US20240174736A1 (en) * | 2021-03-22 | 2024-05-30 | Starmab Biologics (Suzhou) Co., Ltd | Antigen-binding protein targeting pneumolysin and use thereof |
CN117106077B (zh) * | 2022-04-28 | 2024-07-16 | 珠海泰诺麦博制药股份有限公司 | 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体 |
CN115894674B (zh) * | 2022-12-20 | 2023-07-25 | 厦门润康源生物科技有限公司 | 一种用于检测冠状病毒的抗体及制备方法和应用 |
CN116789814B (zh) * | 2023-06-27 | 2024-03-29 | 重庆原伦生物科技有限公司 | 一种特异性结合金黄色葡萄球菌α-溶血素的抗体及其应用 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2437213A1 (fr) | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
GB8426463D0 (en) | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
CA2373221A1 (en) | 1999-05-03 | 2000-11-30 | Yashwant M. Deo | Human antibodies to staphylococcus aureus |
US6573096B1 (en) | 2000-04-01 | 2003-06-03 | The Research Foundation At State University Of New York | Compositions and methods for inhibition of cancer invasion and angiogenesis |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
US7411046B2 (en) | 2005-08-02 | 2008-08-12 | Arius Research Inc | Cancerous disease modifying antibodies |
WO2007081751A2 (en) | 2006-01-05 | 2007-07-19 | The Johns Hopkins University | Compositions and methods for the treatment of cancer |
US7420041B2 (en) | 2006-02-24 | 2008-09-02 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
CN102585002A (zh) | 2006-06-02 | 2012-07-18 | 瑞泽恩制药公司 | 人il-6受体的高亲和力抗体 |
US20180221466A9 (en) | 2006-06-12 | 2018-08-09 | Glaxosmithkline Biologicals S.A. | Use of alpha-toxin for treating and preventing staphylococcus infections |
US20090053235A1 (en) | 2006-06-12 | 2009-02-26 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
KR20100072228A (ko) | 2007-08-31 | 2010-06-30 | 유니버시티 오브 시카고 | 스타필로코커스 폐 질환 및 상태에 대한 면역화와 관련된 방법 및 조성물 |
US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
PL2644192T3 (pl) | 2007-09-28 | 2017-09-29 | Pfizer Inc. | Ukierunkowanie na komórki nowotworowe z zastosowaniem nanocząstek |
JP2011519974A (ja) | 2008-05-12 | 2011-07-14 | ストロックス バイオファーマスーティカルズ,エルエルシー | 黄色ブドウ球菌(Staphylococcusaureus)に特異的な抗体製剤 |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
EP3916011A1 (en) | 2009-06-26 | 2021-12-01 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
EP2284193A1 (en) * | 2009-08-10 | 2011-02-16 | Kenta Biotech AG | Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation |
CA2810030A1 (en) | 2010-09-02 | 2012-03-08 | Excelimmune, Inc. | Staphylococcus aureus specific human recombinant polyclonal antibodies and uses thereof |
RS58190B2 (sr) * | 2011-02-08 | 2021-08-31 | Medimmune Llc | Antitela koja specifično vezuju staphylococcus aureus alfa toksin i postupci njihove primene |
WO2013013323A1 (en) | 2011-07-28 | 2013-01-31 | Cangene Corporation | Staphlococcus aureus alpha-hemolysin antibodies |
WO2013093693A1 (en) | 2011-12-22 | 2013-06-27 | Rinat Neuroscience Corp. | Staphylococcus aureus specific antibodies and uses thereof |
CA2870223A1 (en) | 2012-04-17 | 2013-10-24 | Arsanis Biosciences Gmbh | Cross-reactive staphylococcus aureus antibody |
JP6506172B2 (ja) | 2012-11-06 | 2019-04-24 | メディミューン,エルエルシー | 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法 |
BR112016008275A2 (pt) * | 2013-10-17 | 2017-10-03 | Arsanis Biosciences Gmbh | Anticorpo com reatividade cruzada ao staphylococcus aureus, preparações farmacêuticas ou para diagnóstico compreendendo o anticorpo, anticorpo para uso médico e para diagnóstico, um ácido nucleico isolado que codifica o anticorpo, plasmideo ou cassete de expressao, e célula hospedeira compreendendo tal plasmideo ou cassete de expressao, método para produzir o anticorpo usando tal célula hospedeira, método para produzir variantes de anticorpos, um cristal formado por um monômero da hla ou lukd com dito anticorpo, um paratopo isolado do anticorpo, o epítopo isolado e uma molécula de ligação ligando especificamente ao dito epítopo, um método de triagem para identificar um ligante que se liga ao dito epítopo, um imunógeno compreendendo dito epítopo, e dito imunógeno usado para induzir uma resposta imune protetora |
TWI719938B (zh) | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
TWI702229B (zh) * | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
EP3283514A1 (en) | 2015-04-17 | 2018-02-21 | ARSANIS Biosciences GmbH | Anti-staphylococcus aureus antibody combination preparation |
TWI781130B (zh) | 2017-01-03 | 2022-10-21 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素a毒素之人類抗體 |
-
2017
- 2017-12-29 TW TW106146395A patent/TWI781130B/zh not_active IP Right Cessation
- 2017-12-29 TW TW111136305A patent/TW202311284A/zh unknown
-
2018
- 2018-01-02 CN CN201880005378.7A patent/CN110167960B/zh active Active
- 2018-01-02 AU AU2018206531A patent/AU2018206531A1/en not_active Abandoned
- 2018-01-02 BR BR112019013375-5A patent/BR112019013375A2/pt unknown
- 2018-01-02 EA EA201991643A patent/EA201991643A1/ru unknown
- 2018-01-02 CA CA3048989A patent/CA3048989A1/en active Pending
- 2018-01-02 EP EP18701825.4A patent/EP3565835A1/en active Pending
- 2018-01-02 US US15/860,174 patent/US10463748B2/en active Active
- 2018-01-02 MX MX2019007784A patent/MX2019007784A/es unknown
- 2018-01-02 WO PCT/US2018/012044 patent/WO2018128973A1/en unknown
- 2018-01-02 MA MA047202A patent/MA47202A/fr unknown
- 2018-01-02 JP JP2019536141A patent/JP2020504759A/ja active Pending
- 2018-01-02 KR KR1020197022441A patent/KR20190101435A/ko active Search and Examination
- 2018-01-03 AR ARP180100006A patent/AR110719A1/es unknown
-
2019
- 2019-06-20 PH PH12019501425A patent/PH12019501425A1/en unknown
- 2019-06-24 IL IL267600A patent/IL267600A/en unknown
- 2019-06-27 CO CONC2019/0006902A patent/CO2019006902A2/es unknown
- 2019-07-02 CL CL2019001836A patent/CL2019001836A1/es unknown
- 2019-09-19 US US16/575,755 patent/US10940211B2/en active Active
-
2021
- 2021-01-27 US US17/159,920 patent/US11571482B2/en active Active
-
2022
- 2022-10-25 JP JP2022170270A patent/JP2023011710A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
TW201837054A (zh) | 2018-10-16 |
US10463748B2 (en) | 2019-11-05 |
TW202311284A (zh) | 2023-03-16 |
US20210162059A1 (en) | 2021-06-03 |
JP2020504759A (ja) | 2020-02-13 |
KR20190101435A (ko) | 2019-08-30 |
US10940211B2 (en) | 2021-03-09 |
BR112019013375A2 (pt) | 2020-02-11 |
MA47202A (fr) | 2019-11-13 |
CA3048989A1 (en) | 2018-07-12 |
IL267600A (en) | 2019-08-29 |
WO2018128973A1 (en) | 2018-07-12 |
CL2019001836A1 (es) | 2019-10-04 |
CO2019006902A2 (es) | 2019-07-31 |
CN110167960B (zh) | 2023-01-13 |
PH12019501425A1 (en) | 2020-06-15 |
EA201991643A1 (ru) | 2020-01-20 |
TWI781130B (zh) | 2022-10-21 |
US11571482B2 (en) | 2023-02-07 |
US20180214569A1 (en) | 2018-08-02 |
CN110167960A (zh) | 2019-08-23 |
EP3565835A1 (en) | 2019-11-13 |
AU2018206531A1 (en) | 2019-07-25 |
MX2019007784A (es) | 2019-09-06 |
JP2023011710A (ja) | 2023-01-24 |
US20200016275A1 (en) | 2020-01-16 |
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