EA201990875A1 - Активируемые антитела против ctla-4 и их применение - Google Patents
Активируемые антитела против ctla-4 и их применениеInfo
- Publication number
- EA201990875A1 EA201990875A1 EA201990875A EA201990875A EA201990875A1 EA 201990875 A1 EA201990875 A1 EA 201990875A1 EA 201990875 A EA201990875 A EA 201990875A EA 201990875 A EA201990875 A EA 201990875A EA 201990875 A1 EA201990875 A1 EA 201990875A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ctla
- tumor
- fragment
- activated
- antibodies against
- Prior art date
Links
- 229940045513 CTLA4 antagonist Drugs 0.000 title abstract 6
- 102000008203 CTLA-4 Antigen Human genes 0.000 title abstract 5
- 108010021064 CTLA-4 Antigen Proteins 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 4
- 230000027455 binding Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 102000043321 human CTLA4 Human genes 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 230000006337 proteolytic cleavage Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417212P | 2016-11-03 | 2016-11-03 | |
| PCT/US2017/059740 WO2018085555A1 (en) | 2016-11-03 | 2017-11-02 | Activatable anti-ctla-4 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201990875A1 true EA201990875A1 (ru) | 2019-09-30 |
Family
ID=61132883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201990875A EA201990875A1 (ru) | 2016-11-03 | 2017-11-02 | Активируемые антитела против ctla-4 и их применение |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11117968B2 (enExample) |
| EP (1) | EP3535300B1 (enExample) |
| JP (2) | JP7039582B2 (enExample) |
| KR (2) | KR102814027B1 (enExample) |
| CN (1) | CN110072890B (enExample) |
| AR (1) | AR110678A1 (enExample) |
| AU (1) | AU2017355446A1 (enExample) |
| BR (1) | BR112019008223A2 (enExample) |
| CA (1) | CA3042679A1 (enExample) |
| CL (1) | CL2019001226A1 (enExample) |
| CO (1) | CO2019004469A2 (enExample) |
| EA (1) | EA201990875A1 (enExample) |
| IL (1) | IL265625A (enExample) |
| MX (1) | MX2019004775A (enExample) |
| MY (1) | MY200695A (enExample) |
| PE (1) | PE20191131A1 (enExample) |
| SG (1) | SG11201902857SA (enExample) |
| TW (2) | TW202334213A (enExample) |
| WO (1) | WO2018085555A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015048329A2 (en) | 2013-09-25 | 2015-04-02 | Cytomx Therapeutics, Inc. | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
| IL270562B (en) | 2014-01-31 | 2022-08-01 | Cytomx Therapeutics Inc | Matriptase and u-plasminogen activator polypeptide substrates and other cleanable moieties, compositions comprising same and uses thereof |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| PE20191131A1 (es) | 2016-11-03 | 2019-09-02 | Bristol Myers Squibb Co | Anticuerpos anti antigeno 4 del linfocito t citotoxico (ctla-4) activables y sus usos |
| CA3041279A1 (en) | 2016-11-28 | 2018-05-31 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding domain, and polypeptide including conveying section |
| AU2017364818C1 (en) | 2016-11-28 | 2025-05-15 | Chugai Seiyaku Kabushiki Kaisha | Ligand-binding molecule having adjustable ligand binding activity |
| CA3060618A1 (en) | 2017-05-19 | 2018-11-22 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel monoclonal antibodies to cytotoxic t-lymphocyte-associated protein 4 (ctla-4) |
| KR102771546B1 (ko) | 2017-11-08 | 2025-02-21 | 야페이 상하이 바이오로지 메디신 사이언스 앤드 테크놀로지 컴퍼니 리미티드 | 생체분자의 컨쥬게이트 및 이의 용도 |
| EP3719036A4 (en) | 2017-11-28 | 2021-09-08 | Chugai Seiyaku Kabushiki Kaisha | LIGAND BINDING MOLECULE HAVING ADJUSTABLE LIGAND BINDING ACTIVITY |
| TW201936208A (zh) * | 2017-11-28 | 2019-09-16 | 日商中外製藥股份有限公司 | 含有抗原結合域及運輸部分之多胜肽 |
| EP3769309A1 (en) | 2018-03-20 | 2021-01-27 | Cytomx Therapeutics Inc. | Systems and methods for quantitative pharmacological modeling of activatable antibody species in mammalian subjects |
| MX2020012251A (es) | 2018-05-14 | 2021-04-28 | Werewolf Therapeutics Inc | Polipeptidos de interleucina-2 activables y metodos de uso de los mismos. |
| IL322964A (en) | 2018-05-14 | 2025-10-01 | Werewolf Therapeutics Inc | Activatable interleukin 12 polypeptides and methods of using them |
| US12077577B2 (en) | 2018-05-30 | 2024-09-03 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide comprising aggrecan binding domain and carrying moiety |
| CA3122773A1 (en) | 2018-12-26 | 2020-07-02 | Xilio Development, Inc. | Anti-ctla4 antibodies and methods of use thereof |
| JP7581225B2 (ja) | 2019-03-13 | 2024-11-12 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｃｔｌａ－４遮断剤とｐｄ－１遮断剤とを含む抗癌併用療法 |
| JP7720785B2 (ja) | 2019-04-18 | 2025-08-08 | ブリストル－マイヤーズ スクイブ カンパニー | 低ｐＨで結合するために特異性が増強されたイピリムマブバリアント |
| CA3137512A1 (en) | 2019-05-14 | 2020-11-19 | Werewolf Therapeutics, Inc. | Separation moieties and methods and use thereof |
| CN110498856B (zh) * | 2019-09-17 | 2020-08-11 | 浙江玉安康瑞生物科技有限公司 | 一种ctla-4单克隆抗体5h7及其用于抗肿瘤的用途 |
| CA3160479A1 (en) | 2019-11-08 | 2021-05-14 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for melanoma |
| CA3158532A1 (en) | 2019-12-19 | 2021-06-24 | Susan Wee | Combinations of dgk inhibitors and checkpoint antagonists |
| CA3165414A1 (en) * | 2020-01-17 | 2021-07-22 | Aetio Biotherapy, Inc. | Pro-antibody that reduces off-target toxicity |
| CA3172641A1 (en) * | 2020-04-01 | 2021-10-07 | Xilio Development, Inc. | Masked il-12 cytokines and their cleavage products |
| US12428470B2 (en) | 2020-04-09 | 2025-09-30 | Cytomx Therapeutics, Inc. | Compositions containing activatable antibodies |
| AR122043A1 (es) | 2020-05-12 | 2022-08-03 | Bristol Myers Squibb Co | Dosificación y administración del anticuerpo anti-ctla-4 activable |
| CN115803343A (zh) * | 2020-05-26 | 2023-03-14 | 百奥泰生物制药股份有限公司 | 多特异性抗体及其应用 |
| EP4631977A3 (en) | 2020-08-11 | 2025-12-10 | Janux Therapeutics, Inc. | Cleavable linker compositions and methods |
| US11555078B2 (en) | 2020-12-09 | 2023-01-17 | Janux Therapeutics, Inc. | Compositions and methods related to tumor activated antibodies targeting PSMA and effector cell antigens |
| AU2022230384A1 (en) * | 2021-03-01 | 2023-09-07 | Xilio Development, Inc. | Combination of masked ctla4 and pd1/pdl1 antibodies for treating cancer |
| WO2022271544A1 (en) | 2021-06-21 | 2022-12-29 | Bristol-Myers Squibb Company | Use of sucrose, mannitol and glycine to reduce reconstitution time of high concentration lyophilized biologics drug products |
| WO2023168404A1 (en) | 2022-03-04 | 2023-09-07 | Bristol-Myers Squibb Company | Methods of treating a tumor |
| EP4496816A1 (en) | 2022-03-23 | 2025-01-29 | CytomX Therapeutics, Inc. | Activatable antigen-binding protein constructs and uses of the same |
| EP4499685A1 (en) | 2022-03-25 | 2025-02-05 | CytomX Therapeutics, Inc. | Activatable dual-anchored masked molecules and methods of use thereof |
| US20250230239A1 (en) | 2022-04-01 | 2025-07-17 | Cytomx Therapeutics, Inc. | Cd3-binding proteins and methods of use thereof |
| EP4504257A1 (en) | 2022-04-01 | 2025-02-12 | CytomX Therapeutics, Inc. | Activatable multispecific molecules and methods of use thereof |
| WO2023196987A1 (en) | 2022-04-07 | 2023-10-12 | Bristol-Myers Squibb Company | Methods of treating tumor |
| EP4565690A1 (en) | 2022-08-01 | 2025-06-11 | CytomX Therapeutics, Inc. | Protease-cleavable moieties and methods of use thereof |
| AR130077A1 (es) | 2022-08-01 | 2024-10-30 | Cytomx Therapeutics Inc | Substratos escindibles por proteasas, y métodos de uso de los mismos |
| EP4565332A1 (en) | 2022-08-01 | 2025-06-11 | CytomX Therapeutics, Inc. | Protease-cleavable substrates and methods of use thereof |
| WO2024030845A1 (en) | 2022-08-01 | 2024-02-08 | Cytomx Therapeutics, Inc. | Protease-cleavable moieties and methods of use thereof |
| AR130076A1 (es) | 2022-08-01 | 2024-10-30 | Cytomx Therapeutics Inc | Restos escindibles por proteasas, y métodos de uso de los mismos |
| WO2024031032A1 (en) | 2022-08-05 | 2024-02-08 | Bristol-Myers Squibb Company | Anti-ctla-4 antibodies for treatment of kras mutant cancers |
| EP4582453A1 (en) * | 2022-09-02 | 2025-07-09 | Cichlid Inc. | Anti-ctla-4 monoclonal antibody and use thereof |
| WO2024216170A2 (en) | 2023-04-12 | 2024-10-17 | Cytomx Therapeutics, Inc. | Activatable cytokine constructs and related compositions and methods |
| CN120936384A (zh) | 2023-04-12 | 2025-11-11 | 西托姆克斯治疗公司 | 掩蔽多肽、可活化细胞因子构建体以及相关组合物和方法 |
| CN120958015A (zh) | 2023-04-12 | 2025-11-14 | 西托姆克斯治疗公司 | 掩蔽多肽、可活化细胞因子构建体以及相关组合物和方法 |
| US20250296991A1 (en) | 2023-12-01 | 2025-09-25 | Ablynx N.V. | Precision activated polypeptides |
| WO2025145207A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg-depleting agent |
| WO2025184211A1 (en) | 2024-02-27 | 2025-09-04 | Bristol-Myers Squibb Company | Anti-ceacam5 antibody drug conjugates |
| WO2025184208A1 (en) | 2024-02-27 | 2025-09-04 | Bristol-Myers Squibb Company | Anti-ceacam5 antibodies and uses thereof |
| WO2025240659A2 (en) | 2024-05-14 | 2025-11-20 | Cytomx Therapeutics, Inc. | Activatable constructs, compositions and methods |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5151510A (en) | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
| EP0669836B1 (en) | 1992-11-13 | 1996-07-03 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma |
| PT2180007E (pt) | 1998-04-20 | 2013-11-25 | Roche Glycart Ag | Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| HU228477B1 (en) | 1999-08-23 | 2013-03-28 | Dana Farber Cancer Inst Inc | Pd-1, a receptor for b7-4, and uses therefor |
| CA2589418A1 (en) * | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| EP1286700A2 (en) | 2000-06-01 | 2003-03-05 | Universite Catholique De Louvain | Tumor activated prodrug compounds |
| US7465790B2 (en) | 2000-10-09 | 2008-12-16 | Isis Innovation, Inc. | Therapeutic antibodies |
| ES2368387T5 (es) | 2000-10-09 | 2019-03-07 | Cytomx Therapeutics Inc | Anticuerpos terapéuticos y que inducen tolerancia |
| EP1443961B1 (en) | 2001-10-25 | 2009-05-06 | Genentech, Inc. | Glycoprotein compositions |
| EA200401325A1 (ru) | 2002-04-09 | 2005-04-28 | Киова Хакко Когио Ко., Лтд. | Клетки с модифицированным геномом |
| US20040109855A1 (en) | 2002-07-23 | 2004-06-10 | Herman Waldmann | Therapeutic antibodies with reduced side effect |
| AU2003265866A1 (en) | 2002-09-03 | 2004-03-29 | Vit Lauermann | Targeted release |
| CA2508660C (en) | 2002-12-23 | 2013-08-20 | Wyeth | Antibodies against pd-1 and uses therefor |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| CA2598454C (en) | 2005-02-18 | 2013-04-09 | Medarex, Inc. | Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues |
| PL2161336T5 (pl) | 2005-05-09 | 2017-10-31 | Ono Pharmaceutical Co | Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi |
| PL1907424T3 (pl) | 2005-07-01 | 2015-12-31 | Squibb & Sons Llc | Ludzkie monoklonalne przeciwciała wobec liganda zaprogramowanej śmierci 1 (PD-L1) |
| EP1919931A4 (en) | 2005-08-31 | 2010-01-20 | Univ California | CELLULAR PEPTIDE SEQUENCE LIBRARIES (CLIPS) AND METHOD OF USE THEREOF |
| US20090175886A1 (en) | 2006-01-17 | 2009-07-09 | Medarex, Inc. | Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues |
| US20090220529A1 (en) | 2006-03-10 | 2009-09-03 | Diatos, S.A. | Anticancer Drugs Conjugated to Antibody via an Enzyme Cleavable Linker |
| JP2010507394A (ja) | 2006-10-24 | 2010-03-11 | トルービオン ファーマスーティカルズ インコーポレイテッド | 改良免疫糖タンパク質のための物質および方法 |
| US8354509B2 (en) | 2007-06-18 | 2013-01-15 | Msd Oss B.V. | Antibodies to human programmed death receptor PD-1 |
| US8293685B2 (en) | 2007-07-26 | 2012-10-23 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
| CA3128656A1 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| WO2009100140A1 (en) | 2008-02-04 | 2009-08-13 | Medarex, Inc. | Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| PL2282773T3 (pl) | 2008-05-02 | 2014-08-29 | Seattle Genetics Inc | Sposoby i kompozycje do wytwarzania przeciwciał i pochodnych przeciwciał o obniżonej fukozylacji rdzeniowej |
| RU2017132160A (ru) | 2008-12-09 | 2019-02-08 | Дженентек, Инк. | Антитела к pd-l1 и их применение для усиления функции t-клеток |
| JP5851842B2 (ja) | 2009-01-12 | 2016-02-03 | サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. | 改変した抗体組成物、それを作製および使用する方法 |
| RU2706200C2 (ru) | 2009-11-24 | 2019-11-14 | Медиммьюн Лимитед | Специфические связывающие агенты против в7-н1 |
| SG191955A1 (en) * | 2011-02-15 | 2013-08-30 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
| EP2699264B1 (en) | 2011-04-20 | 2018-03-14 | Medlmmune, LLC | Antibodies and other molecules that bind b7-h1 and pd-1 |
| CN107903325B (zh) | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| CN103987405B (zh) | 2011-11-28 | 2017-03-29 | 默克专利股份公司 | 抗pd‑l1抗体及其用途 |
| CA2871458C (en) * | 2012-04-27 | 2020-06-23 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| IL318221A (en) | 2012-05-15 | 2025-03-01 | Bristol Myers Squibb Co | Cancer immunotherapy by disrupting PD–1/PD–L1 signaling |
| AU2013267161A1 (en) | 2012-05-31 | 2014-11-20 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-L1 |
| AU2013278075B2 (en) | 2012-06-22 | 2018-05-17 | Cytomx Therapeutics, Inc. | Anti-jagged 1/Jagged 2 cross-reactive antibodies, activatable anti-Jagged antibodies and methods of use thereof |
| PT2925350T (pt) * | 2012-12-03 | 2019-03-25 | Bristol Myers Squibb Co | Melhoria da atividade anticancerosa de proteínas de fusão de fc imunomoduladoras |
| JP6742903B2 (ja) | 2013-05-02 | 2020-08-19 | アナプティスバイオ インコーポレイティッド | プログラム死−１（ｐｄ−１）に対する抗体 |
| EA035322B1 (ru) | 2013-05-28 | 2020-05-28 | ДиЭсБи-ЮЭсЭй ЛЛК | Антитело с "запирающими" свойствами для инактивации лекарства белкового происхождения |
| EP3004169B1 (en) | 2013-05-31 | 2023-03-22 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind pd-1 |
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| EP3044234B9 (en) | 2013-09-13 | 2020-08-26 | BeiGene Switzerland GmbH | Anti-pd1 antibodies and their use as therapeutics and diagnostics |
| JP6343011B2 (ja) * | 2013-10-07 | 2018-06-13 | プレステージ バイオファーマ プライベート リミテッド | 抗体発現用バイシストロニック発現ベクター及びそれを用いた抗体の生産方法 |
| MX370449B (es) | 2013-12-12 | 2019-12-13 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de unión al antígeno de este y uso médico de este. |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| US10414814B2 (en) | 2014-07-03 | 2019-09-17 | City Of Hope | Tumor-selective CTLA-4 antagonists |
| US10669337B2 (en) * | 2014-07-25 | 2020-06-02 | Cytomx Therapeutics, Inc. | Bispecific anti-CD3 antibodies, bispecific activatable anti-CD3 antibodies, and methods of using the same |
| ES2881484T3 (es) | 2014-12-22 | 2021-11-29 | Pd 1 Acquisition Group Llc | Anticuerpos anti-PD-1 |
| ES2789351T3 (es) | 2015-01-13 | 2020-10-26 | Hope City | Máscaras de enlace peptídico de proteínas de unión a CTLA4 |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| CN114702586A (zh) * | 2015-03-13 | 2022-07-05 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| EP3307777A4 (en) | 2015-06-11 | 2019-02-13 | Wuxi Biologics (Shanghai) Co. Ltd. | NOVEL ANTI-PD-L1 ANTIBODIES |
| WO2017020291A1 (en) | 2015-08-06 | 2017-02-09 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| WO2017024465A1 (en) | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| AU2016305697B2 (en) | 2015-08-11 | 2023-02-02 | WuXi Biologics Ireland Limited | Novel anti-PD-1 antibodies |
| WO2017024515A1 (en) | 2015-08-11 | 2017-02-16 | Wuxi Biologics (Cayman) Inc. | Novel anti-pd-1 antibodies |
| AR105654A1 (es) | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
| CA2993432A1 (en) | 2015-09-01 | 2017-03-09 | Agenus Inc. | Anti-pd-1 antibodies and methods of use thereof |
| CN108367069B (zh) | 2015-12-14 | 2022-08-23 | 宏观基因有限公司 | 对于pd-1和ctla-4具有免疫反应性的双特异性分子及其使用方法 |
| CN108697776A (zh) | 2016-01-11 | 2018-10-23 | 阿尔莫生物科技股份有限公司 | 在产生抗原特异性cd8+t细胞中的白介素-10及其使用方法 |
| WO2017132827A1 (en) | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| PE20191131A1 (es) | 2016-11-03 | 2019-09-02 | Bristol Myers Squibb Co | Anticuerpos anti antigeno 4 del linfocito t citotoxico (ctla-4) activables y sus usos |
| US11939385B2 (en) | 2017-05-16 | 2024-03-26 | ALX Oncology Inc. | Activatable antibodies and methods of use thereof |
| EP3668545A2 (en) | 2017-08-16 | 2020-06-24 | Bristol-Myers Squibb Company | Prodruggable antibodies, prodrugs thereof, and methods of use and making |
-
2017
- 2017-11-02 PE PE2019000902A patent/PE20191131A1/es unknown
- 2017-11-02 US US16/347,522 patent/US11117968B2/en active Active
- 2017-11-02 MY MYPI2019002439A patent/MY200695A/en unknown
- 2017-11-02 KR KR1020237032965A patent/KR102814027B1/ko active Active
- 2017-11-02 EA EA201990875A patent/EA201990875A1/ru unknown
- 2017-11-02 AU AU2017355446A patent/AU2017355446A1/en not_active Abandoned
- 2017-11-02 WO PCT/US2017/059740 patent/WO2018085555A1/en not_active Ceased
- 2017-11-02 CN CN201780066620.7A patent/CN110072890B/zh active Active
- 2017-11-02 KR KR1020197015448A patent/KR102584340B1/ko active Active
- 2017-11-02 JP JP2019523779A patent/JP7039582B2/ja active Active
- 2017-11-02 SG SG11201902857SA patent/SG11201902857SA/en unknown
- 2017-11-02 CA CA3042679A patent/CA3042679A1/en active Pending
- 2017-11-02 EP EP17837917.8A patent/EP3535300B1/en active Active
- 2017-11-02 BR BR112019008223A patent/BR112019008223A2/pt unknown
- 2017-11-02 MX MX2019004775A patent/MX2019004775A/es unknown
- 2017-11-03 TW TW111141621A patent/TW202334213A/zh unknown
- 2017-11-03 AR ARP170103060A patent/AR110678A1/es unknown
- 2017-11-03 TW TW106138139A patent/TWI784983B/zh not_active IP Right Cessation
-
2019
- 2019-03-26 IL IL265625A patent/IL265625A/en unknown
- 2019-04-30 CO CONC2019/0004469A patent/CO2019004469A2/es unknown
- 2019-05-03 CL CL2019001226A patent/CL2019001226A1/es unknown
-
2021
- 2021-08-11 US US17/399,729 patent/US12441799B2/en active Active
-
2022
- 2022-03-09 JP JP2022036450A patent/JP7472183B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110072890A (zh) | 2019-07-30 |
| TW201819412A (zh) | 2018-06-01 |
| CL2019001226A1 (es) | 2019-09-13 |
| JP7472183B2 (ja) | 2024-04-22 |
| EP3535300B1 (en) | 2025-10-22 |
| KR20190072626A (ko) | 2019-06-25 |
| TW202334213A (zh) | 2023-09-01 |
| KR20230141941A (ko) | 2023-10-10 |
| US20190359714A1 (en) | 2019-11-28 |
| CN110072890B (zh) | 2022-11-29 |
| AU2017355446A1 (en) | 2019-05-02 |
| IL265625A (en) | 2019-05-30 |
| US20220089734A1 (en) | 2022-03-24 |
| EP3535300A1 (en) | 2019-09-11 |
| TWI784983B (zh) | 2022-12-01 |
| JP7039582B2 (ja) | 2022-03-22 |
| WO2018085555A1 (en) | 2018-05-11 |
| KR102584340B1 (ko) | 2023-10-10 |
| WO2018085555A8 (en) | 2018-05-31 |
| US12441799B2 (en) | 2025-10-14 |
| SG11201902857SA (en) | 2019-05-30 |
| US11117968B2 (en) | 2021-09-14 |
| MX2019004775A (es) | 2019-08-05 |
| JP2020500016A (ja) | 2020-01-09 |
| CO2019004469A2 (es) | 2019-05-10 |
| PE20191131A1 (es) | 2019-09-02 |
| CA3042679A1 (en) | 2018-05-11 |
| AR110678A1 (es) | 2019-04-24 |
| BR112019008223A2 (pt) | 2019-07-16 |
| KR102814027B1 (ko) | 2025-05-27 |
| JP2022091800A (ja) | 2022-06-21 |
| MY200695A (en) | 2024-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201990875A1 (ru) | Активируемые антитела против ctla-4 и их применение | |
| PE20161389A1 (es) | Anticuerpos anti-cd38 para el tratamiento de la leucemia linfoblastica aguda | |
| ECSP17005649A (es) | Anticuerpos anti-tau humanizados | |
| EA202191784A1 (ru) | Активируемые маскированные связывающие белки к ctla4 | |
| EA201990912A1 (ru) | Анти-lag-3 антитела и их композиции | |
| EA033403B1 (ru) | Антитела к ингибитору активатора плазминогена 1 (pai-1) и пути их применения | |
| CO2018002265A2 (es) | Anticuerpos anti-cd19 humano humanizados | |
| DOP2017000031A (es) | Anticuerpo monoclonal anti-ctla4 o su fragmento de unión a antígeno, una composición farmacéutica y uso | |
| ES2687282T3 (es) | Anticuerpos humanizados ANTI-CD134 (OX40) y sus usos | |
| ECSP12012309A (es) | Anticuerpos hacia gdf8 humano | |
| JOP20200300A1 (ar) | أجسام مضادة لـ il-11ra | |
| GEP20227438B (en) | Pd-1-binding molecules and methods of use thereof | |
| EA201791527A1 (ru) | Биспецифические антитела против плазменного калликреина и фактора xii | |
| MX377844B (es) | Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso. | |
| NZ631015A (en) | Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases | |
| TR201819812T4 (tr) | Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim | |
| CL2020002600A1 (es) | Anticuerpo anti-muerte programada-ligando 1 y su uso | |
| EA201391312A1 (ru) | Антитело к человеческому тканевому фактору и его применение | |
| JOP20220161A1 (ar) | جسم مضاد لـ lilrb1 واستخداماته | |
| PE20120902A1 (es) | Anticuerpos anti-egfl7 humanizados | |
| NZ594682A (en) | Fully human antibodies specific to cadm1 | |
| BR112021021645A2 (pt) | Anticorpos anti-hvem e uso dos mesmos. | |
| MX390188B (es) | Anticuerpo anti-tie 2 humano novedoso. | |
| WO2019182867A8 (en) | Dual specificity antibodies to human pd-l1 and pd-l2 and methods of use therefor | |
| NZ594452A (en) | Anti-mst1r antibodies and uses thereof |