EA201890725A1 - Агонисты фарнезоидного х-рецептора и их применение - Google Patents

Агонисты фарнезоидного х-рецептора и их применение

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Publication number
EA201890725A1
EA201890725A1 EA201890725A EA201890725A EA201890725A1 EA 201890725 A1 EA201890725 A1 EA 201890725A1 EA 201890725 A EA201890725 A EA 201890725A EA 201890725 A EA201890725 A EA 201890725A EA 201890725 A1 EA201890725 A1 EA 201890725A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
pharneside
application
receptor agonists
receptor
Prior art date
Application number
EA201890725A
Other languages
English (en)
Russian (ru)
Inventor
Николас Д. Смит
Стивен П. Говек
Джонни И. Нагасава
Original Assignee
Метакрайн, Инк.
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Filing date
Publication date
Application filed by Метакрайн, Инк. filed Critical Метакрайн, Инк.
Publication of EA201890725A1 publication Critical patent/EA201890725A1/ru

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    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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