EA201890560A1 - Новые пептиды, комбинации пептидов и каркасы для применения в иммунотерапевтическом методе лечения различных видов рака - Google Patents
Новые пептиды, комбинации пептидов и каркасы для применения в иммунотерапевтическом методе лечения различных видов ракаInfo
- Publication number
- EA201890560A1 EA201890560A1 EA201890560A EA201890560A EA201890560A1 EA 201890560 A1 EA201890560 A1 EA 201890560A1 EA 201890560 A EA201890560 A EA 201890560A EA 201890560 A EA201890560 A EA 201890560A EA 201890560 A1 EA201890560 A1 EA 201890560A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- peptides
- framework
- application
- present
- cancer types
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000001024 immunotherapeutic effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 abstract 2
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 230000005975 antitumor immune response Effects 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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Abstract
Настоящее изобретение относится к пептидам, белкам, нуклеиновым кислотам и клеткам для применения в иммунотерапевтических методах. В частности, настоящее изобретение относится к иммунотерапии рака. Настоящее изобретение относится далее к опухолеассоциированным пептидным эпитопам T-клеток, в отдельности или в комбинации с другими опухолеассоциированными пептидами, которые могут, например, служить в качестве активных фармацевтических ингредиентов вакцинных композиций, стимулирующих противоопухолевые иммунные ответы, или стимулировать T-клетки ex vivo с их перенесением в организм пациента. Пептиды, связанные с молекулами главного комплекса гистосовместимости (МНС), или пептиды в отдельности могут быть также мишенями антител, растворимых T-клеточных рецепторов и других связывающих молекул.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562211276P | 2015-08-28 | 2015-08-28 | |
GBGB1515321.6A GB201515321D0 (en) | 2015-08-28 | 2015-08-28 | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
PCT/EP2016/070146 WO2017036936A1 (en) | 2015-08-28 | 2016-08-26 | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
Publications (1)
Publication Number | Publication Date |
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EA201890560A1 true EA201890560A1 (ru) | 2018-08-31 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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EA201890560A EA201890560A1 (ru) | 2015-08-28 | 2016-08-26 | Новые пептиды, комбинации пептидов и каркасы для применения в иммунотерапевтическом методе лечения различных видов рака |
EA201891874A EA201891874A3 (ru) | 2015-08-28 | 2016-08-26 | Новые пептиды, комбинации пептидов и каркасы для применения в иммунотерапевтическом методе лечения различных видов рака |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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EA201891874A EA201891874A3 (ru) | 2015-08-28 | 2016-08-26 | Новые пептиды, комбинации пептидов и каркасы для применения в иммунотерапевтическом методе лечения различных видов рака |
Country Status (18)
Country | Link |
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US (7) | US10576132B2 (ru) |
EP (2) | EP3341014A1 (ru) |
JP (2) | JP6970974B2 (ru) |
KR (3) | KR102308798B1 (ru) |
CN (1) | CN107921111B (ru) |
AU (3) | AU2016313684B2 (ru) |
BR (1) | BR112018003460A2 (ru) |
CA (2) | CA2996963A1 (ru) |
CR (6) | CR20180423A (ru) |
EA (2) | EA201890560A1 (ru) |
GB (1) | GB201515321D0 (ru) |
MA (7) | MA42694A (ru) |
MX (1) | MX2018002480A (ru) |
PE (2) | PE20181164A1 (ru) |
SG (3) | SG10201807588TA (ru) |
TW (15) | TWI722663B (ru) |
UA (1) | UA124577C2 (ru) |
WO (1) | WO2017036936A1 (ru) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
GB201515321D0 (en) * | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
CN108601731A (zh) | 2015-12-16 | 2018-09-28 | 磨石肿瘤生物技术公司 | 新抗原的鉴别、制造及使用 |
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