EA201791927A1 - Пиразольные соединения и способ получения и применения данных соединений - Google Patents

Пиразольные соединения и способ получения и применения данных соединений

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Publication number
EA201791927A1
EA201791927A1 EA201791927A EA201791927A EA201791927A1 EA 201791927 A1 EA201791927 A1 EA 201791927A1 EA 201791927 A EA201791927 A EA 201791927A EA 201791927 A EA201791927 A EA 201791927A EA 201791927 A1 EA201791927 A1 EA 201791927A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
obtaining
application
pyrazol
data
Prior art date
Application number
EA201791927A
Other languages
English (en)
Other versions
EA039043B1 (ru
Inventor
Райан Келли
Хуэй ЛИ
Тило Хекродт
Янь Чэнь
Даррен Макмартри
Кин Тсо
Ванесса Тэйлор
Раджиндер Сингх
Роуз Йен
Джек Маунг
Original Assignee
Райджел Фармасьютикалз, Инк.
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Application filed by Райджел Фармасьютикалз, Инк. filed Critical Райджел Фармасьютикалз, Инк.
Publication of EA201791927A1 publication Critical patent/EA201791927A1/ru
Publication of EA039043B1 publication Critical patent/EA039043B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

Раскрытые варианты осуществления относятся к новым ингибиторам киназ, ассоциированных с рецептором интерлейкина (IRAK), и композициям, содержащим такие ингибиторы. Также раскрыты способы получения и применения соединений и композиций. Раскрытые соединения и/или композиции можно применять для лечения или предупреждения заболевания или состояния, ассоциированных с IRAK.
EA201791927A 2015-04-22 2016-04-22 Пиразольные соединения и способ получения и применения данных соединений EA039043B1 (ru)

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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102677905B1 (ko) * 2015-04-22 2024-06-24 리겔 파마슈티칼스, 인크. 피라졸 화합물 및 이러한 화합물을 제조하고 사용하는 방법
GB201506872D0 (en) 2015-04-22 2015-06-03 Ge Oil & Gas Uk Ltd Novel compounds
ES2946001T3 (es) 2016-10-26 2023-07-11 Rigel Pharmaceuticals Inc Compuestos de pirazol amida como inhibidores de IRAK
DK3532470T3 (da) 2016-10-26 2023-02-20 Rigel Pharmaceuticals Inc Oxazolderivater til anvendelse som irak-hæmmere og fremgangsmåde til fremstilling deraf
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
US10590121B2 (en) * 2017-06-29 2020-03-17 Rigel Pharmaceuticals, Inc. Kinase inhibitors and methods for making and using
EP3684365A4 (en) 2017-09-22 2021-09-08 Kymera Therapeutics, Inc. PROTEIN DEGRADATION AGENTS AND USES OF SUCH
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc IRAK joints and used in them
CN107987063A (zh) * 2017-12-31 2018-05-04 窦玉玲 一种hsp90抑制剂及其在抗肿瘤药物的应用
CN107857758B (zh) * 2017-12-31 2018-08-24 广东莱恩医药研究院有限公司 一种酰胺类化合物及其作为hsp90抑制剂和抗肿瘤药物的应用
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
AU2019247533B2 (en) * 2018-04-06 2023-09-28 Altos Labs, Inc. ATF6 inhibitors and uses thereof
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
CN117281803A (zh) 2018-07-31 2023-12-26 罗索肿瘤学公司 喷雾干燥的分散体和制剂
CN110862375B (zh) * 2018-08-27 2022-10-25 深圳铂立健医药有限公司 吡唑化合物及其药物组合物和应用
EP3886904A4 (en) 2018-11-30 2022-07-13 Kymera Therapeutics, Inc. IRAQ-TYPE KINASE DEGRADING AGENTS AND THEIR USES
CN114698370A (zh) * 2019-08-08 2022-07-01 里格尔药品股份有限公司 用于治疗细胞因子释放综合征的化合物和方法
MX2022002292A (es) * 2019-08-30 2022-06-02 Rigel Pharmaceuticals Inc Compuestos de pirazol, formulaciones de los mismos y un metodo para usar los compuestos y/o formulaciones.
EP4076520A4 (en) 2019-12-17 2024-03-27 Kymera Therapeutics, Inc. IRAQ DEGRADERS AND USES THEREOF
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
WO2022187303A1 (en) * 2021-03-03 2022-09-09 Rigel Pharmaceuticals, Inc. A method for treating a disease or condition using a pyrazole compound or formulation thereof
MX2023013173A (es) 2021-05-07 2023-11-30 Kymera Therapeutics Inc Degradadores de cinasa 2 dependiente de ciclina (cdk2) y sus usos.
IL308683A (en) * 2021-06-01 2024-01-01 Realta Life Sciences Inc Peptides and methods of use
CN118510771A (zh) * 2021-09-08 2024-08-16 里格尔药品股份有限公司 用于治疗与呼吸道病毒感染相关联的细胞因子释放相关病症的irak抑制剂
US12091411B2 (en) 2022-01-31 2024-09-17 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
AU2023237737A1 (en) * 2022-03-23 2024-10-03 Rigel Pharmaceuticals, Inc. Pyrimid-2-yl-pyrazole compounds as irak inhibitors
WO2024011116A2 (en) * 2022-07-07 2024-01-11 Dana-Farber Cancer Institute, Inc. Potent and selective irreversible inhibitors of irak1
CN117209489B (zh) * 2023-05-30 2024-07-26 杭州邦顺制药有限公司 Irak激酶抑制剂

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003287965A1 (en) * 2002-10-24 2004-05-13 Carex Sa Modulation of peroxisome proliferator activated receptors activity
TWI372050B (en) * 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
JP2008526723A (ja) * 2004-12-30 2008-07-24 アステックス、セラピューティックス、リミテッド Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体
WO2006070202A1 (en) * 2004-12-30 2006-07-06 Astex Therapeutics Limited Pyrazole derivatives having kinase modulating activity
CN101835764B (zh) * 2007-10-24 2012-09-19 安斯泰来制药有限公司 唑甲酰胺化合物或其盐
EP2070925A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel
US8987309B2 (en) 2009-04-17 2015-03-24 The Translational Genomics Research Institute Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles
EP2243481A1 (en) 2009-04-24 2010-10-27 PamGene B.V. Irak kinase family as novel drug target for Alzheimer
JP2012254939A (ja) * 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
WO2011043771A1 (en) 2009-10-07 2011-04-14 Nitto Denko Corporation Narrow band excitation light source for fluorescence sensing system
WO2011124580A1 (en) * 2010-04-07 2011-10-13 F. Hoffmann-La Roche Ag Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
CN108864151A (zh) 2010-11-19 2018-11-23 利亘制药公司 杂环胺及其用途
CA2819378A1 (en) 2010-12-02 2012-06-07 Katholieke Universiteit Leuven, K.U.Leuven R&D Irak-related interventions and diagnosis
HUE029617T2 (en) 2010-12-20 2017-03-28 Merck Serono Sa Indazolyl triazole derivatives as IRAK inhibitors
US8703941B2 (en) 2011-01-10 2014-04-22 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
JPWO2012108511A1 (ja) * 2011-02-09 2014-07-03 日産化学工業株式会社 ピラゾール誘導体および有害生物防除剤
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
CN103987707B (zh) 2011-09-27 2017-11-07 霍夫曼-拉罗奇有限公司 吡唑‑4‑基‑杂环基‑甲酰胺化合物以及使用方法
BR112014017021A8 (pt) 2012-01-10 2017-07-04 Nimbus Iris Inc inibidores de irak e usos dos mesmos
HUE049611T2 (hu) * 2012-09-26 2020-09-28 Hoffmann La Roche Ciklikus éter-pirazol-4-il-heterociklil-karboxamid vegyületek és felhasználási módszerek
EP2903613B1 (en) 2012-10-08 2017-11-22 Merck Sharp & Dohme Corp. Pyrazole derivatives useful as inhibitors of irak4 activity
ES2639717T3 (es) 2013-02-07 2017-10-30 Merck Patent Gmbh Derivados de piridazinona macrocíclicos
CN104968658B (zh) 2013-02-07 2017-08-01 默克专利股份公司 哒嗪酮‑酰胺衍生物
US10314841B2 (en) 2014-01-09 2019-06-11 Merck Patent Gmbh Substituted pyrazoles as IRAK inhibitors
SI3221306T1 (sl) 2014-11-20 2020-03-31 Merck Patent Gmbh Heteroarilne spojine kot inhibitorji IRAK in njihove uporabe
KR102677905B1 (ko) 2015-04-22 2024-06-24 리겔 파마슈티칼스, 인크. 피라졸 화합물 및 이러한 화합물을 제조하고 사용하는 방법
ES2811136T3 (es) * 2015-08-04 2021-03-10 Rigel Pharmaceuticals Inc Compuestos de benzazol y métodos para obtener y usar los compuestos

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