EA201791212A1 - Полипептиды, содержащие аминокислотную последовательность модифицированного бактериофага g3p, в которой отсутствует сигнал гликозилирования - Google Patents
Полипептиды, содержащие аминокислотную последовательность модифицированного бактериофага g3p, в которой отсутствует сигнал гликозилированияInfo
- Publication number
- EA201791212A1 EA201791212A1 EA201791212A EA201791212A EA201791212A1 EA 201791212 A1 EA201791212 A1 EA 201791212A1 EA 201791212 A EA201791212 A EA 201791212A EA 201791212 A EA201791212 A EA 201791212A EA 201791212 A1 EA201791212 A1 EA 201791212A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- amino acid
- modified
- amyloid
- acid sequence
- polypeptides
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1716—Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к полипептидам, которые включают часть гена белка 3 нитчатого бактериофага (g3p), достаточную для связывания с амилоидом и/или дезагрегации амилоида, т.е. часть N1-N2 g3p и его мутантов и фрагментов, где аминокислотная последовательность g3p была модифицирована посредством аминокислотной делеции, инсерции или замены для удаления предполагаемого сигнала гликозилирования. Настоящее изобретение также относится к таким полипептидам, которые также были модифицированы путем замены дополнительной аминокислоты так, чтобы эта последовательность была значительно менее иммуногенной, чем соответствующая аминокислотная последовательность g3p дикого типа при ее использовании in vivo. Полипептиды согласно изобретению сохраняют свою способность связываться с амилоидом и/или дезагрегировать амилоид. Настоящее изобретение также относится к применению этих g3p-модифицированных полипептидов для лечения и/или предупреждения заболеваний, ассоциированных с неправильной укладкой или агрегацией амилоида.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462087052P | 2014-12-03 | 2014-12-03 | |
PCT/US2015/063476 WO2016090022A1 (en) | 2014-12-03 | 2015-12-02 | Polypeptides comprising a modified bacteriophage g3p amino acid sequence lacking a gylcosylation signal |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201791212A1 true EA201791212A1 (ru) | 2018-01-31 |
Family
ID=55273507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791212A EA201791212A1 (ru) | 2014-12-03 | 2015-12-02 | Полипептиды, содержащие аминокислотную последовательность модифицированного бактериофага g3p, в которой отсутствует сигнал гликозилирования |
Country Status (20)
Country | Link |
---|---|
US (2) | US10722551B2 (ru) |
EP (1) | EP3227313B1 (ru) |
JP (2) | JP6730988B2 (ru) |
KR (1) | KR20170085132A (ru) |
CN (1) | CN107250154A (ru) |
AR (1) | AR102890A1 (ru) |
AU (1) | AU2015358504A1 (ru) |
BR (1) | BR112017011530A2 (ru) |
CA (1) | CA2969128A1 (ru) |
DK (1) | DK3227313T3 (ru) |
EA (1) | EA201791212A1 (ru) |
ES (1) | ES2910017T3 (ru) |
IL (1) | IL252426A0 (ru) |
MX (1) | MX2017007059A (ru) |
PH (1) | PH12017501004A1 (ru) |
PL (1) | PL3227313T3 (ru) |
PT (1) | PT3227313T (ru) |
SG (1) | SG11201704427YA (ru) |
TW (1) | TW201632542A (ru) |
WO (1) | WO2016090022A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX362175B (es) | 2011-11-29 | 2019-01-07 | Proclara Biosciences Inc | Composiciones de proteina del gen 3 de bacteriofago y sus usos como agentes de union amiloides. |
LT2906235T (lt) | 2012-10-02 | 2017-10-25 | Proclara Biosciences, Inc. | Bakteriofago sulietų baltymų p3, kaip amiloido rišamųjų agentų, naudojimas |
AU2014274253B2 (en) | 2013-05-28 | 2018-06-14 | Proclara Biosciences, Inc. | Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity |
TW201632542A (zh) | 2014-12-03 | 2016-09-16 | 神經噬菌體製藥股份有限公司 | 包含缺乏醣基化信號之修飾噬菌體g3p胺基酸序列的多肽 |
AU2019287623A1 (en) | 2018-06-15 | 2021-01-07 | Amyl Therapeutics Srl | General amyloid interaction motif (GAIM) |
WO2024119183A1 (en) | 2022-12-02 | 2024-06-06 | Alzheon, Inc. | Methods for treating neurodegenerative disorders with tramiprosate |
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US4215051A (en) | 1979-08-29 | 1980-07-29 | Standard Oil Company (Indiana) | Formation, purification and recovery of phthalic anhydride |
DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
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EP1132471A3 (de) | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
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MX362175B (es) | 2011-11-29 | 2019-01-07 | Proclara Biosciences Inc | Composiciones de proteina del gen 3 de bacteriofago y sus usos como agentes de union amiloides. |
LT2906235T (lt) | 2012-10-02 | 2017-10-25 | Proclara Biosciences, Inc. | Bakteriofago sulietų baltymų p3, kaip amiloido rišamųjų agentų, naudojimas |
AU2014274253B2 (en) * | 2013-05-28 | 2018-06-14 | Proclara Biosciences, Inc. | Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity |
TW201632542A (zh) | 2014-12-03 | 2016-09-16 | 神經噬菌體製藥股份有限公司 | 包含缺乏醣基化信號之修飾噬菌體g3p胺基酸序列的多肽 |
-
2015
- 2015-12-02 TW TW104140347A patent/TW201632542A/zh unknown
- 2015-12-02 CN CN201580065696.9A patent/CN107250154A/zh active Pending
- 2015-12-02 SG SG11201704427YA patent/SG11201704427YA/en unknown
- 2015-12-02 BR BR112017011530A patent/BR112017011530A2/pt not_active Application Discontinuation
- 2015-12-02 WO PCT/US2015/063476 patent/WO2016090022A1/en active Application Filing
- 2015-12-02 ES ES15831011T patent/ES2910017T3/es active Active
- 2015-12-02 PL PL15831011T patent/PL3227313T3/pl unknown
- 2015-12-02 AU AU2015358504A patent/AU2015358504A1/en not_active Abandoned
- 2015-12-02 EA EA201791212A patent/EA201791212A1/ru unknown
- 2015-12-02 MX MX2017007059A patent/MX2017007059A/es unknown
- 2015-12-02 JP JP2017529043A patent/JP6730988B2/ja active Active
- 2015-12-02 PT PT158310110T patent/PT3227313T/pt unknown
- 2015-12-02 CA CA2969128A patent/CA2969128A1/en not_active Abandoned
- 2015-12-02 KR KR1020177017763A patent/KR20170085132A/ko unknown
- 2015-12-02 DK DK15831011.0T patent/DK3227313T3/da active
- 2015-12-02 US US15/532,820 patent/US10722551B2/en active Active
- 2015-12-02 EP EP15831011.0A patent/EP3227313B1/en active Active
- 2015-12-03 AR ARP150103956A patent/AR102890A1/es unknown
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2017
- 2017-05-22 IL IL252426A patent/IL252426A0/en unknown
- 2017-05-31 PH PH12017501004A patent/PH12017501004A1/en unknown
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2020
- 2020-02-19 JP JP2020026300A patent/JP2020073610A/ja not_active Withdrawn
- 2020-06-18 US US16/905,128 patent/US11723951B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2910017T3 (es) | 2022-05-11 |
DK3227313T3 (da) | 2022-04-19 |
PT3227313T (pt) | 2022-04-12 |
WO2016090022A8 (en) | 2017-06-22 |
EP3227313B1 (en) | 2022-02-09 |
JP6730988B2 (ja) | 2020-07-29 |
AR102890A1 (es) | 2017-03-29 |
PL3227313T3 (pl) | 2022-05-09 |
MX2017007059A (es) | 2018-05-02 |
WO2016090022A9 (en) | 2016-08-25 |
BR112017011530A2 (pt) | 2018-03-13 |
WO2016090022A1 (en) | 2016-06-09 |
KR20170085132A (ko) | 2017-07-21 |
TW201632542A (zh) | 2016-09-16 |
SG11201704427YA (en) | 2017-06-29 |
CN107250154A (zh) | 2017-10-13 |
AU2015358504A8 (en) | 2017-07-13 |
US11723951B2 (en) | 2023-08-15 |
EP3227313A1 (en) | 2017-10-11 |
PH12017501004A1 (en) | 2017-12-18 |
US10722551B2 (en) | 2020-07-28 |
US20210015895A1 (en) | 2021-01-21 |
US20180207231A1 (en) | 2018-07-26 |
JP2017538407A (ja) | 2017-12-28 |
CA2969128A1 (en) | 2016-06-09 |
IL252426A0 (en) | 2017-07-31 |
AU2015358504A1 (en) | 2017-06-29 |
JP2020073610A (ja) | 2020-05-14 |
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