EA201790857A1 - Состав красителя для тканей и клеток с новой молекулой, полученной из papaver rhoeas - Google Patents
Состав красителя для тканей и клеток с новой молекулой, полученной из papaver rhoeasInfo
- Publication number
- EA201790857A1 EA201790857A1 EA201790857A EA201790857A EA201790857A1 EA 201790857 A1 EA201790857 A1 EA 201790857A1 EA 201790857 A EA201790857 A EA 201790857A EA 201790857 A EA201790857 A EA 201790857A EA 201790857 A1 EA201790857 A1 EA 201790857A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- papaver rhoeas
- composition
- dye
- hematoxylin
- tissues
- Prior art date
Links
- 240000004674 Papaver rhoeas Species 0.000 title abstract 7
- 235000007846 Papaver rhoeas Nutrition 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 5
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 abstract 8
- 238000010186 staining Methods 0.000 abstract 3
- 239000012472 biological sample Substances 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 2
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 abstract 2
- 230000002195 synergetic effect Effects 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 240000007829 Haematoxylum campechianum Species 0.000 abstract 1
- 238000005481 NMR spectroscopy Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000007431 microscopic evaluation Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- -1 tetrahydro-3,4,5-trihydroxy-6-methyl-2H-pyran-2-yloxy Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B13/00—Oxyketone dyes
- C09B13/06—Oxyketone dyes of the acetophenone series
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B65/00—Compositions containing mordants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N2001/302—Stain compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Biotechnology (AREA)
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- Genetics & Genomics (AREA)
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- Wood Science & Technology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
Abstract
Составляют краситель для клеток и тканей из Papaver rhoeas, включающий новый биофлавоноид, специфически окрашивающий ядро, используемый для микроскопической оценки в гистопатологии, микробиологии и цитологии. По-видимому, он является альтернативой гематоксилину в рутинном применении. Биохимическое название этого соединения: тетрагидро-3,4,5-тригидрокси-6-метил-2Н-пиран-2-илокси)метил) 2Н-пиран-2,3,4,5-тетраол)-4-метоксифенил)-7-метокси-4Н-хромен-4-он. Анализ ЯМР показал, что биохимическая структура молекулы представляет собой биофлавоноид (фиг. 4, 5). Молекула из Papaver rhoeas вместе с синергическими и другими молекулами проникает в биологические и небиологические образцы. При ее комбинировании с другими синергическими механизмами получают состав красителя. Количество и тип протравы и рН являются параметрами, влияющими на качество и время окрашивания. Состав Papaver rhoeas получают, в частности, для исследования тканей для диагностики в лабораториях и больницах, и он предназначен для рутинного применения. Миллионы биологических образцов по всему миру исследуют, такие как полученные в ходе хирургической операции и биологические препараты, являющиеся образцами, окрашиваемыми для диагностики. Краситель для тканей гематоксилин используют рутинно, его получают из деревьев под названием Hematoxylin campechianum (кампешевое дерево), представляющее собой часть мировых тропических лесов. Каждый год 3000 кампешевых деревьев, а также участков, вырубают для получения приблизительно 1200 т порошка и 70000 т жидкого красителя гематоксилина ($15 млрд/год). Состав из Papaver rhoeas обеспечивает эффективное и специфическое окрашивание, позволяющее выделить ядро. Помимо очевидной экономической выгоды, Papaver rhoeas широко распространен, и его легко можно собирать и получать. Состав Papaver rhoeas также оказывает экологическое влияние на Землю, что позволяет ему быть важным и полезным промышленным продуктом.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR201412329 | 2014-10-21 | ||
| PCT/TR2014/000410 WO2016064353A1 (en) | 2014-10-21 | 2014-11-18 | Tissue and cell stain formula with a novel molecule obtained from papaver rhoeas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201790857A1 true EA201790857A1 (ru) | 2017-12-29 |
| EA034938B1 EA034938B1 (ru) | 2020-04-08 |
Family
ID=52347385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201790857A EA034938B1 (ru) | 2014-10-21 | 2014-11-18 | Состав красителя для тканей и клеток с новой молекулой, полученной из papaver rhoeas |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10527527B2 (ru) |
| EP (1) | EP3209292B1 (ru) |
| JP (1) | JP6564030B2 (ru) |
| KR (1) | KR20170100486A (ru) |
| CN (1) | CN107205980B (ru) |
| EA (1) | EA034938B1 (ru) |
| WO (1) | WO2016064353A1 (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3622266B1 (en) * | 2017-05-10 | 2022-08-17 | Ventana Medical Systems, Inc. | Stabilized two-part hematoxylin solution utilizing ph adjustment, method for staining and kit |
| CN107246988A (zh) * | 2017-06-06 | 2017-10-13 | 珠海贝索生物技术有限公司 | 一种抗酸性菌染色方法 |
| KR101982521B1 (ko) | 2018-04-04 | 2019-05-27 | 부산대학교병원 | 염료 및 고차가지구조 고분자의 합성 복합체를 유효성분으로 포함하는 조직 염색 화합물 및 그의 제조방법 |
| CN108479427B (zh) * | 2018-05-25 | 2020-05-22 | 南京佳乐净膜科技有限公司 | 抗菌除重金属共混改性的聚合物膜的制备方法 |
| CN108918236B (zh) * | 2018-08-01 | 2020-12-01 | 中国农业科学院烟草研究所 | 一种烟草主茎徒手切片快速双重染色液 |
| CN111829858A (zh) * | 2019-04-18 | 2020-10-27 | 湖北文理学院 | 实验发现两种简单、低廉、来源丰富的新型组织切片染色剂 |
| RU2725291C1 (ru) * | 2019-05-27 | 2020-06-30 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Тихоокеанский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ донозологической неинвазивной диагностики состояния здоровья работников |
| WO2020261299A1 (en) * | 2019-06-28 | 2020-12-30 | Rajiv Gandhi University Of Health Sciences | Method for preparing biodegradable staining composition |
| CN111018893B (zh) * | 2019-11-25 | 2020-09-25 | 桂林医学院 | 一种含硫氨基醇席夫碱铜配合物及其制备和应用 |
| KR102332433B1 (ko) * | 2020-01-13 | 2021-11-30 | 사회복지법인 삼성생명공익재단 | 조직 염색용 조성물 및 이를 이용한 조직 염색 방법 |
| CN111337332A (zh) * | 2020-03-17 | 2020-06-26 | 宁波江丰生物信息技术有限公司 | 一种巴氏染色液ea50及其制备方法 |
| WO2021194436A1 (en) * | 2020-03-26 | 2021-09-30 | Nanobiomed Sağlik Ve Yaşam Bilimleri A. Ş. | The natural antiviral and anti-inflammatory compound consist of bioflavonoids which extracted from papaver rhoeas red petals |
| CN111624065B (zh) * | 2020-05-22 | 2023-10-27 | 嘉兴优瑞生物科技有限公司 | 一种动物专用Diff-Quik染液及制备方法 |
| CN111982626B (zh) * | 2020-08-20 | 2023-07-25 | 江苏瑞思坦生物科技有限公司 | 一种软骨球快速石蜡切片鉴定方法 |
| CN112649595B (zh) * | 2020-11-11 | 2022-02-22 | 西安交通大学 | 一种基于单脉冲激光诱导光致击穿可控射流的系统和方法 |
| KR102635263B1 (ko) * | 2021-11-18 | 2024-02-08 | 경희대학교 산학협력단 | 양귀비속 식물의 추출물을 포함하는 항산화 및 항염증용 조성물 |
| CN115200963A (zh) * | 2022-07-15 | 2022-10-18 | 重庆医科大学附属儿童医院 | 一种油红o染色液及油红o染色方法 |
| CN115317516B (zh) * | 2022-08-29 | 2023-07-25 | 中南大学 | 一种超小抗氧化纳米点及其在急性肾损伤中的应用 |
| CN118090377A (zh) * | 2024-04-28 | 2024-05-28 | 北京大学第一医院(北京大学第一临床医学院) | 一种用于肾穿刺组织活检光镜特殊染色的试剂盒及染色方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9317071D0 (en) * | 1993-08-17 | 1993-09-29 | Univ Strathclyde | Flavonoids |
| US6159445A (en) * | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
| US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
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2014
- 2014-11-18 WO PCT/TR2014/000410 patent/WO2016064353A1/en active Application Filing
- 2014-11-18 EP EP14827290.9A patent/EP3209292B1/en active Active
- 2014-11-18 JP JP2017522199A patent/JP6564030B2/ja not_active Expired - Fee Related
- 2014-11-18 CN CN201480083507.6A patent/CN107205980B/zh not_active Expired - Fee Related
- 2014-11-18 US US15/520,860 patent/US10527527B2/en not_active Expired - Fee Related
- 2014-11-18 EA EA201790857A patent/EA034938B1/ru not_active IP Right Cessation
- 2014-11-18 KR KR1020177013541A patent/KR20170100486A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016064353A1 (en) | 2016-04-28 |
| CN107205980A (zh) | 2017-09-26 |
| CN107205980B (zh) | 2020-04-07 |
| JP2018505649A (ja) | 2018-03-01 |
| JP6564030B2 (ja) | 2019-08-21 |
| US20170315031A1 (en) | 2017-11-02 |
| EP3209292A1 (en) | 2017-08-30 |
| US10527527B2 (en) | 2020-01-07 |
| EP3209292B1 (en) | 2020-03-11 |
| EA034938B1 (ru) | 2020-04-08 |
| KR20170100486A (ko) | 2017-09-04 |
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