EA201790796A1 - НОВОЕ 5,6-ДИГИДРО-4H-БЕНЗО[b]ТИЕНО-[2,3-d]АЗЕПИНОВОЕ ПРОИЗВОДНОЕ - Google Patents

НОВОЕ 5,6-ДИГИДРО-4H-БЕНЗО[b]ТИЕНО-[2,3-d]АЗЕПИНОВОЕ ПРОИЗВОДНОЕ

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Publication number
EA201790796A1
EA201790796A1 EA201790796A EA201790796A EA201790796A1 EA 201790796 A1 EA201790796 A1 EA 201790796A1 EA 201790796 A EA201790796 A EA 201790796A EA 201790796 A EA201790796 A EA 201790796A EA 201790796 A1 EA201790796 A1 EA 201790796A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thieno
benzo
derivative
digidro
azepin
Prior art date
Application number
EA201790796A
Other languages
English (en)
Other versions
EA201790796A8 (ru
Inventor
Саймон Фрейзер Хант
Стюарт Томас Онионз
Владимир Шербухин
Юэн Александер Фрейзер Фордайс
Питер Джон Мюррей
Дэниел Уильям Брукс
Кадзухиро Ито
Питер Стронг
Original Assignee
Палмосайд Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Палмосайд Лимитед filed Critical Палмосайд Лимитед
Publication of EA201790796A1 publication Critical patent/EA201790796A1/ru
Publication of EA201790796A8 publication Critical patent/EA201790796A8/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Представлено 5,6-дигидро-4H-бензо[b]тиено-[2,3-d]азепиновое производное (как определено в раскрытии), которое пригодно в лечении РСВ-инфекции и для профилактики заболевания, связанного с РСВ-инфекцией.
EA201790796A 2014-10-10 2015-10-08 НОВОЕ 5,6-ДИГИДРО-4H-БЕНЗО[b]ТИЕНО-[2,3-d]АЗЕПИНОВОЕ ПРОИЗВОДНОЕ EA201790796A8 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14188494 2014-10-10
PCT/GB2015/052944 WO2016055791A1 (en) 2014-10-10 2015-10-08 Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative

Publications (2)

Publication Number Publication Date
EA201790796A1 true EA201790796A1 (ru) 2017-09-29
EA201790796A8 EA201790796A8 (ru) 2018-10-31

Family

ID=51842340

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790796A EA201790796A8 (ru) 2014-10-10 2015-10-08 НОВОЕ 5,6-ДИГИДРО-4H-БЕНЗО[b]ТИЕНО-[2,3-d]АЗЕПИНОВОЕ ПРОИЗВОДНОЕ

Country Status (13)

Country Link
US (6) US10189863B2 (ru)
EP (2) EP3204389B1 (ru)
JP (2) JP6675407B2 (ru)
KR (1) KR20170058921A (ru)
CN (1) CN106852144B (ru)
AU (1) AU2015329789B2 (ru)
BR (1) BR112017005104B1 (ru)
CA (1) CA2957868C (ru)
EA (1) EA201790796A8 (ru)
IL (1) IL250823A0 (ru)
MX (1) MX2017004652A (ru)
SG (1) SG11201701184WA (ru)
WO (2) WO2016055791A1 (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10189863B2 (en) 2014-10-10 2019-01-29 Pulmocide Limited 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives
EP3233867B1 (en) 2014-12-18 2018-10-17 Pulmocide Limited 4,5-dihydro-6h-thieno[3,2-d]benzazepine derivatives and their use to treat respiratory syncytial virus (rsv) infections
PL3324977T3 (pl) 2015-07-22 2022-11-14 Enanta Pharmaceuticals, Inc. Pochodne benzodiazepiny jako inhibitory rsv
US20170226129A1 (en) 2016-01-15 2017-08-10 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
KR20180108598A (ko) * 2016-02-03 2018-10-04 얀센 사이언시즈 아일랜드 유씨 Rsv의 치료를 위한 조합 생성물
US10626126B2 (en) * 2016-04-08 2020-04-21 Pulmocide Limited Compounds
WO2018129287A1 (en) 2017-01-06 2018-07-12 Enanta Pharmaceuticals, Inc. Heteroaryldiazepine derivatives as rsv inhibitors
ES2923521T3 (es) 2017-02-16 2022-09-28 Enanta Pharm Inc Procesos para la preparación de derivados de benzodiazepina
US10752598B2 (en) 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2019006295A1 (en) * 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
CA3077309A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. Combination pharmaceutical agents as rsv inhibitors
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
AU2018365174B2 (en) 2017-11-13 2023-03-30 Enanta Pharmaceuticals, Inc. Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives
US10975094B2 (en) 2018-04-11 2021-04-13 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US11254664B2 (en) 2019-03-18 2022-02-22 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as RSV inhibitors
WO2020210246A1 (en) * 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
KR20220101083A (ko) 2019-10-04 2022-07-19 이난타 파마슈티칼스, 인코포레이티드 항바이러스 헤테로사이클릭 화합물
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
EP4298103A1 (en) 2021-02-26 2024-01-03 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693635A (en) 1993-07-29 1997-12-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
CZ20013834A3 (cs) 1999-04-28 2002-04-17 Aventis Pharma Deutschland Gmbh Deriváty kyselin se třemi arylovými zbytky jako ligandy receptorů PPAR a farmaceutické prostředky, které je obsahují
AU2009204147A1 (en) * 2008-01-07 2009-07-16 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
WO2011005842A1 (en) * 2009-07-09 2011-01-13 Gilead Sciences, Inc. Anti-rsv compounds
ES2749504T3 (es) 2009-10-13 2020-03-20 Ligand Pharm Inc Compuestos de moléculas pequeñas miméticos del factor de crecimiento hematopoyético y sus usos
AU2011283684B2 (en) 2010-07-29 2015-08-27 Rigel Pharmaceuticals, Inc. AMPK-activating heterocyclic compounds and methods for using the same
US9464065B2 (en) 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
SG10201901010PA (en) 2014-08-05 2019-03-28 Alios Biopharma Inc Combination therapy for treating a paramyxovirus
US10189863B2 (en) * 2014-10-10 2019-01-29 Pulmocide Limited 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives
US20170226129A1 (en) 2016-01-15 2017-08-10 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
KR20180108598A (ko) 2016-02-03 2018-10-04 얀센 사이언시즈 아일랜드 유씨 Rsv의 치료를 위한 조합 생성물
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS

Also Published As

Publication number Publication date
MX2017004652A (es) 2017-06-19
US10035810B2 (en) 2018-07-31
CA2957868C (en) 2023-02-28
US10189863B2 (en) 2019-01-29
KR20170058921A (ko) 2017-05-29
US20170305935A1 (en) 2017-10-26
CN106852144B (zh) 2019-08-30
SG11201701184WA (en) 2017-03-30
EP3204389A1 (en) 2017-08-16
IL250823A0 (en) 2017-04-30
US20180179228A1 (en) 2018-06-28
CN106852144A (zh) 2017-06-13
JP2017531039A (ja) 2017-10-19
US20190202841A1 (en) 2019-07-04
AU2015329789A1 (en) 2017-03-09
US10472375B2 (en) 2019-11-12
US20170355717A1 (en) 2017-12-14
WO2016055792A1 (en) 2016-04-14
JP6675407B2 (ja) 2020-04-01
EA201790796A8 (ru) 2018-10-31
US9926335B2 (en) 2018-03-27
EP3204388A1 (en) 2017-08-16
BR112017005104A2 (pt) 2017-12-05
EP3204389B1 (en) 2019-06-26
US20180319820A1 (en) 2018-11-08
US9732098B2 (en) 2017-08-15
CA2957868A1 (en) 2016-04-14
AU2015329789B2 (en) 2019-09-26
WO2016055791A1 (en) 2016-04-14
JP2017531038A (ja) 2017-10-19
BR112017005104B1 (pt) 2022-08-23
US20170190718A1 (en) 2017-07-06
US10273249B2 (en) 2019-04-30
EP3204388B1 (en) 2018-12-12

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