EA201692332A1 - Борсодержащие ингибиторы протеасом для применения после первичной противораковой терапии - Google Patents
Борсодержащие ингибиторы протеасом для применения после первичной противораковой терапииInfo
- Publication number
- EA201692332A1 EA201692332A1 EA201692332A EA201692332A EA201692332A1 EA 201692332 A1 EA201692332 A1 EA 201692332A1 EA 201692332 A EA201692332 A EA 201692332A EA 201692332 A EA201692332 A EA 201692332A EA 201692332 A1 EA201692332 A1 EA 201692332A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bordeaux
- cancer therapy
- primary anti
- proteas
- inhibitors
- Prior art date
Links
- 241000208465 Proteaceae Species 0.000 title 1
- 238000011319 anticancer therapy Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 235000019419 proteases Nutrition 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 229940079156 Proteasome inhibitor Drugs 0.000 abstract 1
- 239000003207 proteasome inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462000991P | 2014-05-20 | 2014-05-20 | |
| US201462019600P | 2014-07-01 | 2014-07-01 | |
| US201462088154P | 2014-12-05 | 2014-12-05 | |
| PCT/US2015/031633 WO2015179443A1 (en) | 2014-05-20 | 2015-05-19 | Boron-containing proteasome inhibitors for use after primary cancer therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201692332A1 true EA201692332A1 (ru) | 2017-04-28 |
Family
ID=54554652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201692332A EA201692332A1 (ru) | 2014-05-20 | 2015-05-19 | Борсодержащие ингибиторы протеасом для применения после первичной противораковой терапии |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20150335668A1 (OSRAM) |
| EP (1) | EP3145526A1 (OSRAM) |
| JP (2) | JP2017524652A (OSRAM) |
| KR (2) | KR102509950B1 (OSRAM) |
| CN (1) | CN106659761A (OSRAM) |
| AU (2) | AU2015264272A1 (OSRAM) |
| BR (1) | BR112016026774A8 (OSRAM) |
| CA (1) | CA2949517A1 (OSRAM) |
| CL (1) | CL2016002948A1 (OSRAM) |
| CR (1) | CR20160577A (OSRAM) |
| EA (1) | EA201692332A1 (OSRAM) |
| IL (2) | IL249025B (OSRAM) |
| MA (1) | MA39964A (OSRAM) |
| MX (2) | MX2016015267A (OSRAM) |
| PH (1) | PH12016502301A1 (OSRAM) |
| SG (2) | SG10202003693RA (OSRAM) |
| TN (1) | TN2016000492A1 (OSRAM) |
| TW (1) | TWI746422B (OSRAM) |
| UA (1) | UA121389C2 (OSRAM) |
| UY (1) | UY36132A (OSRAM) |
| WO (1) | WO2015179443A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11268154B2 (en) | 2015-11-04 | 2022-03-08 | Takeda Pharmaceutical Company Limited | Methods for the identification, evaluation and treatment of patients having multiple myeloma |
| MA45862A (fr) * | 2016-08-04 | 2021-05-05 | Millennium Pharm Inc | Combinaison d'inhibiteurs du protéasome et d'anticorps anti-cd30 |
| US11230709B2 (en) * | 2016-12-28 | 2022-01-25 | National University Corporation Kobe University | Therapeutic drug for Alport's syndrome |
| US11414437B2 (en) | 2017-07-28 | 2022-08-16 | Chengdu Origin Biotechnology Limited Company | Borate compound, and synthesis method therefor and uses thereof |
| WO2023107487A1 (en) * | 2021-12-06 | 2023-06-15 | Pretzel Therapeutics, Inc. | Lonp1 inhibitor compounds, uses and methods |
Family Cites Families (60)
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| US2160413A (en) | 1935-04-16 | 1939-05-30 | Schering Ag | Polyiodo derivatives of acylamino acids and their salts and a method of making the same |
| NZ203706A (en) | 1982-04-22 | 1986-03-14 | Squibb & Sons Inc | Occlusive multi-layer wound dressing and hydrocolloidal granules for wound treatment |
| US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
| JPS6233170A (ja) | 1985-08-07 | 1987-02-13 | Tokuyama Soda Co Ltd | 環状ポリエ−テル化合物 |
| JPH0813759B2 (ja) | 1986-09-01 | 1996-02-14 | 富士写真フイルム株式会社 | アルコキシベンゼン誘導体の製造方法 |
| JP2512303B2 (ja) | 1987-03-20 | 1996-07-03 | 呉羽化学工業株式会社 | ２−オキサゾリン−４，５−ジオンのフエニルヒドラゾン誘導体 |
| US5250720A (en) | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
| US5242904A (en) | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
| US5159060A (en) | 1988-05-27 | 1992-10-27 | Mayo Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
| US5106948A (en) | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
| DE3827340A1 (de) | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
| MX9206628A (es) | 1991-11-22 | 1993-05-01 | Boehringer Ingelheim Pharma | Ester de prolinaboronato y metodo para su preparacion. |
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| EP0583536B1 (en) | 1992-08-14 | 1997-03-05 | The Procter & Gamble Company | Liquid detergents containing an alpha-amino boronic acid |
| US5935944A (en) | 1993-09-10 | 1999-08-10 | Neutron Technology Corporation | Formulation for I.V. administration of the boron delivery drug, boronophenylalanine (BPA) |
| US5492900A (en) | 1993-09-10 | 1996-02-20 | Neutron Technology Corporation | Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA) |
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| FR2712602B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
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| US5834487A (en) | 1996-09-24 | 1998-11-10 | Cv Therapeutics | Inhibition of 26S and 20S proteasome by indanones |
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-
2015
- 2015-05-19 WO PCT/US2015/031633 patent/WO2015179443A1/en not_active Ceased
- 2015-05-19 EP EP15726483.9A patent/EP3145526A1/en not_active Withdrawn
- 2015-05-19 UY UY0001036132A patent/UY36132A/es not_active Application Discontinuation
- 2015-05-19 TW TW104115971A patent/TWI746422B/zh active
- 2015-05-19 KR KR1020227022220A patent/KR102509950B1/ko active Active
- 2015-05-19 UA UAA201612860A patent/UA121389C2/uk unknown
- 2015-05-19 SG SG10202003693RA patent/SG10202003693RA/en unknown
- 2015-05-19 MX MX2016015267A patent/MX2016015267A/es unknown
- 2015-05-19 CA CA2949517A patent/CA2949517A1/en not_active Abandoned
- 2015-05-19 AU AU2015264272A patent/AU2015264272A1/en not_active Abandoned
- 2015-05-19 TN TN2016000492A patent/TN2016000492A1/en unknown
- 2015-05-19 CN CN201580029362.6A patent/CN106659761A/zh active Pending
- 2015-05-19 KR KR1020167033753A patent/KR102481856B1/ko active Active
- 2015-05-19 BR BR112016026774A patent/BR112016026774A8/pt not_active Application Discontinuation
- 2015-05-19 US US14/716,761 patent/US20150335668A1/en not_active Abandoned
- 2015-05-19 SG SG11201609259VA patent/SG11201609259VA/en unknown
- 2015-05-19 JP JP2016568591A patent/JP2017524652A/ja active Pending
- 2015-05-19 EA EA201692332A patent/EA201692332A1/ru unknown
- 2015-05-19 CR CR20160577A patent/CR20160577A/es unknown
- 2015-05-19 MA MA039964A patent/MA39964A/fr unknown
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2016
- 2016-11-17 IL IL249025A patent/IL249025B/en active IP Right Grant
- 2016-11-17 PH PH12016502301A patent/PH12016502301A1/en unknown
- 2016-11-18 MX MX2021009044A patent/MX2021009044A/es unknown
- 2016-11-18 CL CL2016002948A patent/CL2016002948A1/es unknown
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2018
- 2018-12-21 US US16/229,524 patent/US20190125773A1/en not_active Abandoned
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2019
- 2019-06-04 JP JP2019104381A patent/JP6906564B2/ja active Active
- 2019-07-22 US US16/517,963 patent/US20190343851A1/en not_active Abandoned
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2020
- 2020-02-04 US US16/781,432 patent/US20200171061A1/en not_active Abandoned
- 2020-04-19 IL IL274042A patent/IL274042A/en unknown
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2021
- 2021-01-20 AU AU2021200370A patent/AU2021200370B2/en not_active Ceased
- 2021-03-01 US US17/188,492 patent/US11241448B2/en active Active
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