EA201691747A1 - Варианты комбинированной терапии с антителами анти-cd38 - Google Patents

Варианты комбинированной терапии с антителами анти-cd38

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Publication number
EA201691747A1
EA201691747A1 EA201691747A EA201691747A EA201691747A1 EA 201691747 A1 EA201691747 A1 EA 201691747A1 EA 201691747 A EA201691747 A EA 201691747A EA 201691747 A EA201691747 A EA 201691747A EA 201691747 A1 EA201691747 A1 EA 201691747A1
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antibody
dependent
options
vitro
relates
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EA201691747A
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English (en)
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Парул Доши
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Янссен Байотек, Инк.
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Publication of EA201691747A1 publication Critical patent/EA201691747A1/ru

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    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Abstract

Настоящее изобретение относится к медицине. Настоящее изобретение относится к способу лечения субъекта, имеющего CD38-положительную гематологическую злокачественную опухоль, включающему введение нуждающемуся в этом пациенту антитела анти-CD38 в комбинации с циклофосфамидом, доксорубицином, винкристином и преднизоном (CHOP), причем антитело анти-CD38 индуцирует уничтожение CD38-экспрессирующих клеток in vitro за счет антителозависимой клеточно-опосредованной цитотоксичности (ADCC), антителозависимого клеточного фагоцитоза (ADCP), комплемент-зависимой цитотоксичности (CDC), апоптоза или модуляции ферментативной активности CD38 in vitro. Изобретение позволяет эффективно лечить неходжкинскую лимфому (НХЛ) и B-клеточные злокачественные заболевания.
EA201691747A 2014-02-28 2015-02-25 Варианты комбинированной терапии с антителами анти-cd38 EA201691747A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461946002P 2014-02-28 2014-02-28
US201462006386P 2014-06-02 2014-06-02
PCT/US2015/017420 WO2015130728A1 (en) 2014-02-28 2015-02-25 Combination therapies with anti-cd38 antibodies

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US (3) US9603927B2 (ru)
EP (1) EP3110843B1 (ru)
JP (1) JP6670248B2 (ru)
KR (1) KR20160126026A (ru)
CN (1) CN106459184B (ru)
AU (1) AU2015223205B2 (ru)
BR (1) BR112016019866A2 (ru)
CA (1) CA2940864C (ru)
CL (1) CL2016002158A1 (ru)
CR (1) CR20160388A (ru)
CY (1) CY1122398T1 (ru)
DK (1) DK3110843T3 (ru)
DO (1) DOP2016000224A (ru)
EA (1) EA201691747A1 (ru)
ES (1) ES2756349T3 (ru)
GT (1) GT201600172A (ru)
HR (1) HRP20192058T1 (ru)
HU (1) HUE046028T2 (ru)
IL (1) IL247392B (ru)
LT (1) LT3110843T (ru)
ME (1) ME03583B (ru)
MX (1) MX2016011186A (ru)
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PE (1) PE20161175A1 (ru)
PH (1) PH12016501700A1 (ru)
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RS (1) RS59516B1 (ru)
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SI (1) SI3110843T1 (ru)
SV (1) SV2016005267A (ru)
UA (1) UA120926C2 (ru)
WO (1) WO2015130728A1 (ru)
ZA (2) ZA201606682B (ru)

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