EA201690050A1 - Композиции и способы для применения в медицинской диагностике - Google Patents
Композиции и способы для применения в медицинской диагностикеInfo
- Publication number
- EA201690050A1 EA201690050A1 EA201690050A EA201690050A EA201690050A1 EA 201690050 A1 EA201690050 A1 EA 201690050A1 EA 201690050 A EA201690050 A EA 201690050A EA 201690050 A EA201690050 A EA 201690050A EA 201690050 A1 EA201690050 A1 EA 201690050A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nanoparticle
- nanoparticles
- aggregates
- compositions
- methods
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
- A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0457—Semi-solid forms, ointments, gels, hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
Настоящее изобретение относится к композициям и способам для применения в медицинской диагностике и мониторинге пациента. Более конкретно оно относится к биологически совместимому гелю, содержащему наночастицы и/или агрегаты наночастиц, где i) наночастица и/или агрегат наночастиц содержит неорганическое вещество, содержащее по меньшей мере один являющийся металлом элемент с атомным номером Z по меньшей мере 25, где каждые из указанной наночастицы и указанного агрегата наночастиц являются покрытыми биологически совместимым покрытием; ii) концентрация наночастиц и/или агрегатов наночастиц составляет приблизительно 0,5% (мас./мас.) или менее и iii) эффективная вязкость при 2 сгеля, содержащего наночастицы и/или агрегаты наночастиц, составляет приблизительно от 0,1 приблизительно до 1000 Па×с при измерении в диапазоне от 20 до 37°С. Композиция по изобретению, как правило, обеспечивает оконтуривание и визуализацию по меньшей мере 40% биологической ткани-мишени, когда указанную ткань наблюдают с использованием оборудования для рентгеновской визуализации.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361837389P | 2013-06-20 | 2013-06-20 | |
| EP13305831 | 2013-06-20 | ||
| PCT/EP2014/062947 WO2014202723A1 (en) | 2013-06-20 | 2014-06-19 | Compositions and methods for use in medical diagnosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201690050A1 true EA201690050A1 (ru) | 2016-05-31 |
Family
ID=48745869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201690050A EA201690050A1 (ru) | 2013-06-20 | 2014-06-19 | Композиции и способы для применения в медицинской диагностике |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10588987B2 (ru) |
| EP (1) | EP3010495B1 (ru) |
| JP (1) | JP6560665B2 (ru) |
| KR (1) | KR20160027009A (ru) |
| CN (1) | CN105431141A (ru) |
| AU (1) | AU2014283217A1 (ru) |
| BR (1) | BR112015031977A2 (ru) |
| CA (1) | CA2915430A1 (ru) |
| EA (1) | EA201690050A1 (ru) |
| HK (1) | HK1222562A1 (ru) |
| MA (1) | MA38709A1 (ru) |
| MX (1) | MX2015017774A (ru) |
| SG (1) | SG11201510021TA (ru) |
| WO (1) | WO2014202723A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6042450B2 (ja) | 2011-12-16 | 2016-12-14 | ナノビオティックスＮａｎｏｂｉｏｔｉｘ | 金属材料および酸化ハフニウム材料を含むナノ粒子、その製造および使用 |
| CN107708668A (zh) | 2015-05-28 | 2018-02-16 | 纳米生物技术公司 | 用作治疗性疫苗的纳米粒子 |
| CN105097174B (zh) * | 2015-08-12 | 2018-06-22 | 华南理工大学 | 一种木聚糖季铵盐纳米磁性颗粒及其制备方法 |
| CA3047651A1 (en) * | 2016-12-21 | 2018-06-28 | Nanobiotix | Nanoparticles for use for enhancing brain performances or for treating stress |
| WO2018114945A1 (en) * | 2016-12-21 | 2018-06-28 | Nanobiotix | Nanoparticles for use for treating a neuronal disorder |
| KR101949347B1 (ko) * | 2017-05-24 | 2019-02-18 | 이화여자대학교 산학협력단 | 유방암의 재발 예측을 위한 정보제공방법 |
| JP7376901B2 (ja) * | 2017-11-13 | 2023-11-09 | 国立大学法人北海道大学 | 修飾金属ナノ粒子及び医薬組成物 |
| CN107998395A (zh) * | 2017-12-14 | 2018-05-08 | 天津市赛宁生物工程技术有限公司 | 一种双功能乳腺靶标及制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6161034A (en) | 1999-02-02 | 2000-12-12 | Senorx, Inc. | Methods and chemical preparations for time-limited marking of biopsy sites |
| US20050084869A1 (en) * | 2003-10-20 | 2005-04-21 | Sung Hyun Kim | Novel composition and methods for the diagnosis of lung cancer |
| FR2869803B1 (fr) * | 2004-05-10 | 2006-07-28 | Nanobiotix Sarl | Particules activables, preparation et utilisations |
| DE102006041495A1 (de) | 2006-08-29 | 2008-03-20 | Friedrich-Schiller-Universität Jena | Substanzgemisch zur lokalen Deposition von Magnetpartikeln in einem Medium, insbesondere in tumorbefallenem organischem Gewebe, sowie Applikationskit zur Verabreichung |
| DE102008008522A1 (de) | 2008-02-11 | 2009-08-13 | Magforce Nanotechnologies Ag | Implantierbare Nanopartikel-enthaltende Produkte |
| EP2130553A1 (en) * | 2008-06-05 | 2009-12-09 | Nanobiotix | Inorganic nanoparticles of high density to destroy cells in-vivo |
| EP2275137A1 (en) * | 2009-07-10 | 2011-01-19 | Nanobiotix | Metallic nanoparticles, preparation and uses thereof |
| EP3960215A1 (en) | 2009-12-15 | 2022-03-02 | Incept, LLC | Implants and biodegradable fiducial markers |
| WO2013076305A1 (en) * | 2011-11-25 | 2013-05-30 | Danmarks Tekniske Universitet | Formulation of solid nano-sized particles in a gel-forming system |
| JP6042450B2 (ja) * | 2011-12-16 | 2016-12-14 | ナノビオティックスＮａｎｏｂｉｏｔｉｘ | 金属材料および酸化ハフニウム材料を含むナノ粒子、その製造および使用 |
| WO2014121224A2 (en) * | 2013-02-01 | 2014-08-07 | The Trustees Of Dartmouth College | Biodegradable iron oxide nanoparticle gel for tumor bed therapy |
| SI3010552T1 (sl) * | 2013-06-20 | 2019-08-30 | Nanobiotix | Sestavki za uporabo v onkologiji |
-
2014
- 2014-06-19 JP JP2016520491A patent/JP6560665B2/ja active Active
- 2014-06-19 CN CN201480034960.8A patent/CN105431141A/zh active Pending
- 2014-06-19 AU AU2014283217A patent/AU2014283217A1/en not_active Abandoned
- 2014-06-19 US US14/898,763 patent/US10588987B2/en active Active
- 2014-06-19 KR KR1020167001660A patent/KR20160027009A/ko not_active Application Discontinuation
- 2014-06-19 SG SG11201510021TA patent/SG11201510021TA/en unknown
- 2014-06-19 WO PCT/EP2014/062947 patent/WO2014202723A1/en active Application Filing
- 2014-06-19 MX MX2015017774A patent/MX2015017774A/es unknown
- 2014-06-19 EA EA201690050A patent/EA201690050A1/ru unknown
- 2014-06-19 MA MA38709A patent/MA38709A1/fr unknown
- 2014-06-19 CA CA2915430A patent/CA2915430A1/en not_active Abandoned
- 2014-06-19 EP EP14731285.4A patent/EP3010495B1/en active Active
- 2014-06-19 BR BR112015031977A patent/BR112015031977A2/pt not_active IP Right Cessation
-
2016
- 2016-09-12 HK HK16110780.5A patent/HK1222562A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3010495B1 (en) | 2021-06-16 |
| HK1222562A1 (zh) | 2017-07-07 |
| JP2016527204A (ja) | 2016-09-08 |
| CA2915430A1 (en) | 2014-12-24 |
| SG11201510021TA (en) | 2016-01-28 |
| US10588987B2 (en) | 2020-03-17 |
| BR112015031977A2 (pt) | 2017-07-25 |
| EP3010495A1 (en) | 2016-04-27 |
| AU2014283217A1 (en) | 2015-12-24 |
| WO2014202723A1 (en) | 2014-12-24 |
| MA38709A1 (fr) | 2018-05-31 |
| CN105431141A (zh) | 2016-03-23 |
| JP6560665B2 (ja) | 2019-08-14 |
| US20160136303A1 (en) | 2016-05-19 |
| KR20160027009A (ko) | 2016-03-09 |
| MX2015017774A (es) | 2016-03-31 |
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