EA201491199A1 - Наночастицы, включающие металлические материал и материал оксида гафния, композиция и ее применение - Google Patents

Наночастицы, включающие металлические материал и материал оксида гафния, композиция и ее применение

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Publication number
EA201491199A1
EA201491199A1 EA201491199A EA201491199A EA201491199A1 EA 201491199 A1 EA201491199 A1 EA 201491199A1 EA 201491199 A EA201491199 A EA 201491199A EA 201491199 A EA201491199 A EA 201491199A EA 201491199 A1 EA201491199 A1 EA 201491199A1
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EA
Eurasian Patent Office
Prior art keywords
nanoparticles
hafnium oxide
composition
application
including metal
Prior art date
Application number
EA201491199A
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English (en)
Other versions
EA029635B1 (ru
Inventor
Аньес Поттье
Лоран Леви
Мари-Эдит Мер
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Нанобиотикс
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Application filed by Нанобиотикс filed Critical Нанобиотикс
Publication of EA201491199A1 publication Critical patent/EA201491199A1/ru
Publication of EA029635B1 publication Critical patent/EA029635B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/242—Gold; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Powder Metallurgy (AREA)

Abstract

Настоящее изобретение относится к новым наночастицам, которые можно преимущественно применять в области здоровья в качестве диагностических и/или терапевтических средств. Наночастицы изобретения включают металлический материал, по меньшей мере, частично покрытый материалом оксида гафния или внедренный в него. По сравнению с существующими продуктами эти наночастицы предлагают заметную эффективность, превышающую индекс риска. Конкретно эти наночастицы потенциируют эффективность известных металлических наночастиц. На самом деле они сохраняют собственные свойства металла и сейчас в дополнение применяются у млекопитающих, в частности у людей. Изобретение также относится к способам производства указанных наночастиц, к композициям, их содержащим, и к их применению.
EA201491199A 2011-12-16 2012-12-17 Применение наночастицы, включающей металлический материал, покрытый материалом оксида гафния, в онкологии и композиция, ее содержащая EA029635B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161576437P 2011-12-16 2011-12-16
EP11193968 2011-12-16
PCT/EP2012/075731 WO2013087920A1 (en) 2011-12-16 2012-12-17 Nanoparticles comprising metallic and hafnium oxide materials, preparation and uses thereof

Publications (2)

Publication Number Publication Date
EA201491199A1 true EA201491199A1 (ru) 2014-11-28
EA029635B1 EA029635B1 (ru) 2018-04-30

Family

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EA201491199A EA029635B1 (ru) 2011-12-16 2012-12-17 Применение наночастицы, включающей металлический материал, покрытый материалом оксида гафния, в онкологии и композиция, ее содержащая

Country Status (16)

Country Link
US (1) US10945965B2 (ru)
EP (1) EP2790682B1 (ru)
JP (1) JP6042450B2 (ru)
KR (1) KR102025743B1 (ru)
CN (1) CN104093401B (ru)
AU (1) AU2012351537B2 (ru)
BR (1) BR112014014412A2 (ru)
CA (1) CA2857260C (ru)
EA (1) EA029635B1 (ru)
HK (1) HK1203353A1 (ru)
IL (1) IL233035B (ru)
MA (1) MA35851B1 (ru)
MX (1) MX362089B (ru)
PL (1) PL2790682T3 (ru)
SG (1) SG11201403096VA (ru)
WO (1) WO2013087920A1 (ru)

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AU2012351537B2 (en) 2017-03-02
MX362089B (es) 2019-01-07
MA35851B1 (fr) 2014-12-01
CA2857260C (en) 2019-10-15
EP2790682A1 (en) 2014-10-22
CN104093401A (zh) 2014-10-08
JP2015509079A (ja) 2015-03-26
KR20140108685A (ko) 2014-09-12
HK1203353A1 (en) 2015-10-30
JP6042450B2 (ja) 2016-12-14
MX2014007131A (es) 2014-09-04
NZ625848A (en) 2015-04-24
PL2790682T3 (pl) 2019-08-30
US10945965B2 (en) 2021-03-16
US20140335015A1 (en) 2014-11-13
CN104093401B (zh) 2018-06-29
EP2790682B1 (en) 2019-03-20
CA2857260A1 (en) 2013-06-20
KR102025743B1 (ko) 2019-09-26
BR112014014412A2 (pt) 2017-06-13
WO2013087920A1 (en) 2013-06-20
EA029635B1 (ru) 2018-04-30
AU2012351537A1 (en) 2014-07-24
IL233035B (en) 2018-02-28
IL233035A0 (en) 2014-07-31
SG11201403096VA (en) 2014-07-30

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