EA201492281A1 - Соединения n-арилтриазола в качестве антагонистов рецепторов лизофосфатидной кислоты (lpar) - Google Patents
Соединения n-арилтриазола в качестве антагонистов рецепторов лизофосфатидной кислоты (lpar)Info
- Publication number
- EA201492281A1 EA201492281A1 EA201492281A EA201492281A EA201492281A1 EA 201492281 A1 EA201492281 A1 EA 201492281A1 EA 201492281 A EA201492281 A EA 201492281A EA 201492281 A EA201492281 A EA 201492281A EA 201492281 A1 EA201492281 A1 EA 201492281A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antagonists
- compounds
- lyophasophatic
- lpar
- acid receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261661953P | 2012-06-20 | 2012-06-20 | |
PCT/EP2013/062463 WO2013189865A1 (en) | 2012-06-20 | 2013-06-17 | N-aryltriazole compounds as lpar antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201492281A1 true EA201492281A1 (ru) | 2015-04-30 |
Family
ID=48628669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201492281A EA201492281A1 (ru) | 2012-06-20 | 2013-06-17 | Соединения n-арилтриазола в качестве антагонистов рецепторов лизофосфатидной кислоты (lpar) |
Country Status (22)
Country | Link |
---|---|
US (1) | US20150133512A1 (es) |
EP (1) | EP2864301A1 (es) |
JP (1) | JP2015520203A (es) |
KR (1) | KR20150011389A (es) |
CN (1) | CN104395299A (es) |
AU (1) | AU2013279513A1 (es) |
BR (1) | BR112014030674A2 (es) |
CA (1) | CA2869564A1 (es) |
CL (1) | CL2014003241A1 (es) |
CO (1) | CO7131357A2 (es) |
EA (1) | EA201492281A1 (es) |
HK (1) | HK1206339A1 (es) |
IL (1) | IL236087A0 (es) |
IN (1) | IN2014DN09352A (es) |
MA (1) | MA37762B1 (es) |
MX (1) | MX2014014711A (es) |
PE (1) | PE20142305A1 (es) |
PH (1) | PH12014502363A1 (es) |
SG (1) | SG11201407228PA (es) |
UA (1) | UA110310C2 (es) |
WO (1) | WO2013189865A1 (es) |
ZA (1) | ZA201408167B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2744807A4 (en) | 2011-08-15 | 2015-03-04 | Intermune Inc | COMPOUNDS AS LYSOPHOSPHIC ACID RECEPTOR ANTAGONISTS |
TW201437200A (zh) * | 2013-01-15 | 2014-10-01 | Intermune Inc | 溶血磷脂酸受體拮抗劑 |
SG11201507459YA (en) | 2013-03-15 | 2015-10-29 | Epigen Biosciences Inc | Heterocyclic compounds useful in the treatment of disease |
UY36060A (es) | 2014-04-02 | 2015-10-30 | Bayer Pharma AG | Compuestos de azol sustituidos con amida |
AU2015281021B9 (en) | 2014-06-27 | 2019-03-28 | Ube Corporation | Salt of halogen-substituted heterocyclic compound |
WO2017055316A1 (en) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Amido-substituted azole compounds |
WO2017055313A1 (en) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Amido-substituted azole compounds |
AR108838A1 (es) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa |
WO2018078005A1 (en) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Amido-substituted azaspiro derivatives as tankyrase inhibitors |
WO2018078009A1 (en) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Amido-substituted cyclohexane derivatives |
WO2018087126A1 (en) | 2016-11-09 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Amido-substituted cyclohexane derivatives as inhibitors of tankyrase |
CN107721984A (zh) * | 2017-11-07 | 2018-02-23 | 大连理工大学 | 一种新型5‑酰胺基‑1,4,5‑三取代的1,2,3‑三氮唑的制备方法 |
CN107827829A (zh) * | 2017-11-07 | 2018-03-23 | 大连理工大学 | 5‑酰胺基‑1,4,5‑三取代的1,2,3‑三氮唑在水相及生物介质中的制备方法 |
EP3728222B1 (en) | 2017-12-19 | 2023-03-29 | Bristol-Myers Squibb Company | Cyclohexyl acid pyrazole azines as lpa antagonists |
EP3728210A1 (en) | 2017-12-19 | 2020-10-28 | Bristol-Myers Squibb Company | Isoxazole n-linked carbamoyl cyclohexyl acids as lpa antagonists |
JP7369125B2 (ja) * | 2017-12-19 | 2023-10-25 | ブリストル-マイヤーズ スクイブ カンパニー | Lpaアンタゴニストとしてのイソキサゾールo-架橋カルバモイルシクロヘキシル酸 |
CN112074515A (zh) | 2017-12-19 | 2020-12-11 | 百时美施贵宝公司 | 作为lpa拮抗剂的环己基酸异噁唑唑类 |
TW202017918A (zh) | 2017-12-19 | 2020-05-16 | 美商必治妥美雅史谷比公司 | 作為lpa拮抗劑之環己基酸三唑吖 |
BR112020011953A2 (pt) | 2017-12-19 | 2020-11-17 | Bristol-Myers Squibb Company | ácidos carbamoil ciclo-hexílicos n-ligados a pirazol como antagonistas de lpa |
BR112020012177A2 (pt) | 2017-12-19 | 2020-11-24 | Bristol-Myers Squibb Company | azóis triazóis do ácido ciclo-hexílico como antagonistas de lpa |
US11261174B2 (en) | 2017-12-19 | 2022-03-01 | Bristol-Myers Squibb Company | Pyrazole O-linked carbamoyl cyclohexyl acids as LPA antagonists |
WO2019126086A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azines as lpa antagonists |
JP7212047B2 (ja) | 2017-12-19 | 2023-01-24 | ブリストル-マイヤーズ スクイブ カンパニー | Lpaアンタゴニストとしてのシクロヘキシル酸ピラゾールアゾール |
CN111434653A (zh) * | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 三氮唑类化合物及其制备方法与用途 |
EP4058144A1 (en) | 2019-11-15 | 2022-09-21 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
US11702407B2 (en) | 2020-06-03 | 2023-07-18 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
IL298082A (en) | 2020-06-03 | 2023-01-01 | Gilead Sciences Inc | lpa receptor antagonists and uses thereof |
KR20240005892A (ko) | 2021-05-11 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
WO2023107938A1 (en) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
CN115745848A (zh) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | 一种氨基胍的加工合成工艺 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011159550A2 (en) * | 2010-06-14 | 2011-12-22 | Amidra Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonist and uses thereof |
WO2011159633A1 (en) * | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Inhalable formulations of lysophosphatdic acid receptor antagonists |
BR112013014019A2 (pt) * | 2010-12-07 | 2016-09-13 | Amira Pharmaceuticals Inc | antagonistas do receptor do ácido lisofosfatídico e seus usos |
WO2012138648A1 (en) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
EP2744807A4 (en) * | 2011-08-15 | 2015-03-04 | Intermune Inc | COMPOUNDS AS LYSOPHOSPHIC ACID RECEPTOR ANTAGONISTS |
BR112014030685A2 (pt) * | 2012-06-20 | 2017-06-27 | Hoffmann La Roche | compostos de n-alquiltriazol como antagonistas de lpar |
-
2013
- 2013-06-17 KR KR1020147035551A patent/KR20150011389A/ko not_active Application Discontinuation
- 2013-06-17 US US14/403,261 patent/US20150133512A1/en not_active Abandoned
- 2013-06-17 BR BR112014030674A patent/BR112014030674A2/pt not_active Application Discontinuation
- 2013-06-17 PE PE2014002213A patent/PE20142305A1/es not_active Application Discontinuation
- 2013-06-17 JP JP2015517705A patent/JP2015520203A/ja active Pending
- 2013-06-17 IN IN9352DEN2014 patent/IN2014DN09352A/en unknown
- 2013-06-17 MA MA37762A patent/MA37762B1/fr unknown
- 2013-06-17 CA CA2869564A patent/CA2869564A1/en not_active Abandoned
- 2013-06-17 CN CN201380031806.0A patent/CN104395299A/zh active Pending
- 2013-06-17 EA EA201492281A patent/EA201492281A1/ru unknown
- 2013-06-17 EP EP13729332.0A patent/EP2864301A1/en not_active Withdrawn
- 2013-06-17 AU AU2013279513A patent/AU2013279513A1/en not_active Abandoned
- 2013-06-17 SG SG11201407228PA patent/SG11201407228PA/en unknown
- 2013-06-17 MX MX2014014711A patent/MX2014014711A/es unknown
- 2013-06-17 WO PCT/EP2013/062463 patent/WO2013189865A1/en active Application Filing
- 2013-06-17 UA UAA201500426A patent/UA110310C2/uk unknown
-
2014
- 2014-10-22 PH PH12014502363A patent/PH12014502363A1/en unknown
- 2014-11-07 ZA ZA2014/08167A patent/ZA201408167B/en unknown
- 2014-11-20 CO CO14255124A patent/CO7131357A2/es unknown
- 2014-11-28 CL CL2014003241A patent/CL2014003241A1/es unknown
- 2014-12-04 IL IL236087A patent/IL236087A0/en unknown
-
2015
- 2015-07-21 HK HK15106924.1A patent/HK1206339A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2013189865A1 (en) | 2013-12-27 |
MA37762B1 (fr) | 2018-04-30 |
IN2014DN09352A (es) | 2015-07-17 |
CA2869564A1 (en) | 2013-12-27 |
ZA201408167B (en) | 2015-12-23 |
MA37762A1 (fr) | 2017-07-31 |
CL2014003241A1 (es) | 2015-03-20 |
IL236087A0 (en) | 2015-02-01 |
HK1206339A1 (en) | 2016-01-08 |
MX2014014711A (es) | 2015-03-04 |
SG11201407228PA (en) | 2014-12-30 |
PH12014502363A1 (en) | 2015-01-12 |
AU2013279513A1 (en) | 2014-10-16 |
US20150133512A1 (en) | 2015-05-14 |
BR112014030674A2 (pt) | 2017-06-27 |
CN104395299A (zh) | 2015-03-04 |
KR20150011389A (ko) | 2015-01-30 |
PE20142305A1 (es) | 2015-01-16 |
JP2015520203A (ja) | 2015-07-16 |
UA110310C2 (uk) | 2015-12-10 |
CO7131357A2 (es) | 2014-12-01 |
EP2864301A1 (en) | 2015-04-29 |
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