IN2014DN09352A - - Google Patents

Info

Publication number
IN2014DN09352A
IN2014DN09352A IN9352DEN2014A IN2014DN09352A IN 2014DN09352 A IN2014DN09352 A IN 2014DN09352A IN 9352DEN2014 A IN9352DEN2014 A IN 9352DEN2014A IN 2014DN09352 A IN2014DN09352 A IN 2014DN09352A
Authority
IN
India
Prior art keywords
compounds
disorders
substituents
useful
formula
Prior art date
Application number
Inventor
Stephen Deems Gabriel
Matthew Michael Hamilton
Yimin Qian
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48628669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN09352(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IN2014DN09352A publication Critical patent/IN2014DN09352A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof wherein the substituents are as those disclosed in the specification. These compounds and the pharmaceutical compositions containing them are useful for the treatment of inflammatory diseases and disorders such as for example pulmonary fibrosis.
IN9352DEN2014 2012-06-20 2013-06-17 IN2014DN09352A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661953P 2012-06-20 2012-06-20
PCT/EP2013/062463 WO2013189865A1 (en) 2012-06-20 2013-06-17 N-aryltriazole compounds as lpar antagonists

Publications (1)

Publication Number Publication Date
IN2014DN09352A true IN2014DN09352A (en) 2015-07-17

Family

ID=48628669

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9352DEN2014 IN2014DN09352A (en) 2012-06-20 2013-06-17

Country Status (22)

Country Link
US (1) US20150133512A1 (en)
EP (1) EP2864301A1 (en)
JP (1) JP2015520203A (en)
KR (1) KR20150011389A (en)
CN (1) CN104395299A (en)
AU (1) AU2013279513A1 (en)
BR (1) BR112014030674A2 (en)
CA (1) CA2869564A1 (en)
CL (1) CL2014003241A1 (en)
CO (1) CO7131357A2 (en)
EA (1) EA201492281A1 (en)
HK (1) HK1206339A1 (en)
IL (1) IL236087A0 (en)
IN (1) IN2014DN09352A (en)
MA (1) MA37762B1 (en)
MX (1) MX2014014711A (en)
PE (1) PE20142305A1 (en)
PH (1) PH12014502363A1 (en)
SG (1) SG11201407228PA (en)
UA (1) UA110310C2 (en)
WO (1) WO2013189865A1 (en)
ZA (1) ZA201408167B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2744807A4 (en) 2011-08-15 2015-03-04 Intermune Inc ANTAGONISTS OF LYSOPHOSPHATIDE ACID RECEPTORS
TW201437200A (en) * 2013-01-15 2014-10-01 Intermune Inc Lysophosphatidic acid receptor antagonists
SG11201507459YA (en) 2013-03-15 2015-10-29 Epigen Biosciences Inc Heterocyclic compounds useful in the treatment of disease
UY36060A (en) 2014-04-02 2015-10-30 Bayer Pharma AG AZOL COMPOUNDS REPLACED WITH AMIDA
WO2015199234A1 (en) 2014-06-27 2015-12-30 宇部興産株式会社 Salt of halogen-substituted heterocyclic compound
WO2017055313A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
WO2017055316A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
AR108838A1 (en) 2016-06-21 2018-10-03 Bristol Myers Squibb Co CARBAMOYLOXIMETHYL ACID TRIAZOL CYCLOHEXILO AS LPA ANTAGONISTS
WO2018078005A1 (en) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Amido-substituted azaspiro derivatives as tankyrase inhibitors
WO2018078009A1 (en) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives
WO2018087126A1 (en) 2016-11-09 2018-05-17 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives as inhibitors of tankyrase
CN107721984A (en) * 2017-11-07 2018-02-23 大连理工大学 A kind of preparation method of trisubstituted 1,2,3 triazole of new 5 amide groups 1,4,5
CN107827829A (en) * 2017-11-07 2018-03-23 大连理工大学 Preparation method of 5 amide groups, 1,4,5 trisubstituted 1,2,3 triazole in aqueous phase and Biomedia
ES2962367T3 (en) 2017-12-19 2024-03-18 Bristol Myers Squibb Co N-linked pyrazole carbamoyl cyclohexylic acids as lysophosphatidic acid (LPA) receptor antagonists
CA3085561A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Cyclohexyl acid triazole azines as lpa antagonists
JP7202383B2 (en) 2017-12-19 2023-01-11 ブリストル－マイヤーズ スクイブ カンパニー Pyrazole O-bridged carbamoylcyclohexylates as LPA antagonists
US11447475B2 (en) 2017-12-19 2022-09-20 Bristol-Myers Squibb Company Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists
CN111712492B (en) 2017-12-19 2024-05-31 百时美施贵宝公司 Cyclohexyl acid triazoles as LPA antagonists
JP7369125B2 (en) * 2017-12-19 2023-10-25 ブリストル－マイヤーズ スクイブ カンパニー Isoxazole O-bridged carbamoylcyclohexylate as LPA antagonist
KR102725744B1 (en) 2017-12-19 2024-11-01 브리스톨-마이어스 스큅 컴퍼니 Cyclohexyl pyrazole azine as an LPA antagonist
US11319309B2 (en) 2017-12-19 2022-05-03 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azines as LPA antagonists
JP7212047B2 (en) 2017-12-19 2023-01-24 ブリストル－マイヤーズ スクイブ カンパニー Cyclohexylate Pyrazole Azoles as LPA Antagonists
WO2019126087A1 (en) * 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azoles as lpa antagonists
ES2946657T3 (en) 2018-09-18 2023-07-24 Bristol Myers Squibb Co Cyclopentyl acids as LPA antagonists
JP7412424B2 (en) 2018-09-18 2024-01-12 ブリストル－マイヤーズ スクイブ カンパニー Oxabicycloic acid as an LPA antagonist
CN111434653A (en) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 Triazole compounds and preparation method and use thereof
CN114728168B (en) 2019-11-15 2024-04-09 吉利德科学公司 Triazole carbamate pyridylsulfonamide as LPA receptor antagonist and its use
US11702407B2 (en) 2020-06-03 2023-07-18 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
TWI843503B (en) 2020-06-03 2024-05-21 美商基利科學股份有限公司 Lpa receptor antagonists and uses thereof
AU2022273631B2 (en) 2021-05-11 2025-04-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
KR20240007233A (en) 2021-05-13 2024-01-16 길리애드 사이언시즈, 인코포레이티드 LPA receptor antagonists and uses thereof
US11939318B2 (en) 2021-12-08 2024-03-26 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
CN115745848A (en) * 2022-12-07 2023-03-07 上海优合生物科技有限公司 Processing and synthesizing process of aminoguanidine
US20240343695A1 (en) * 2023-03-06 2024-10-17 Lakehead University Lysophosphatidic Acid Receptor 1 Antagonists as Migrastatics for Cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011159550A2 (en) * 2010-06-14 2011-12-22 Amidra Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonist and uses thereof
WO2011159633A1 (en) * 2010-06-15 2011-12-22 Amira Pharmaceuticals, Inc. Inhalable formulations of lysophosphatdic acid receptor antagonists
WO2012078593A2 (en) * 2010-12-07 2012-06-14 Amira Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonists and uses thereof
WO2012138648A1 (en) * 2011-04-06 2012-10-11 Irm Llc Compositions and methods for modulating lpa receptors
EP2744807A4 (en) * 2011-08-15 2015-03-04 Intermune Inc ANTAGONISTS OF LYSOPHOSPHATIDE ACID RECEPTORS
SG11201407220YA (en) * 2012-06-20 2014-12-30 Hoffmann La Roche N-alkyltriazole compounds as lpar antagonists

Also Published As

Publication number Publication date
IL236087A0 (en) 2015-02-01
CL2014003241A1 (en) 2015-03-20
MX2014014711A (en) 2015-03-04
CN104395299A (en) 2015-03-04
WO2013189865A1 (en) 2013-12-27
HK1206339A1 (en) 2016-01-08
PE20142305A1 (en) 2015-01-16
MA37762A1 (en) 2017-07-31
AU2013279513A1 (en) 2014-10-16
KR20150011389A (en) 2015-01-30
PH12014502363A1 (en) 2015-01-12
BR112014030674A2 (en) 2017-06-27
CO7131357A2 (en) 2014-12-01
CA2869564A1 (en) 2013-12-27
EA201492281A1 (en) 2015-04-30
US20150133512A1 (en) 2015-05-14
UA110310C2 (en) 2015-12-10
JP2015520203A (en) 2015-07-16
SG11201407228PA (en) 2014-12-30
EP2864301A1 (en) 2015-04-29
MA37762B1 (en) 2018-04-30
ZA201408167B (en) 2015-12-23

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