IN2014DN09352A - - Google Patents
Info
- Publication number
- IN2014DN09352A IN2014DN09352A IN9352DEN2014A IN2014DN09352A IN 2014DN09352 A IN2014DN09352 A IN 2014DN09352A IN 9352DEN2014 A IN9352DEN2014 A IN 9352DEN2014A IN 2014DN09352 A IN2014DN09352 A IN 2014DN09352A
- Authority
- IN
- India
- Prior art keywords
- compounds
- disorders
- substituents
- useful
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
Abstract
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof wherein the substituents are as those disclosed in the specification. These compounds and the pharmaceutical compositions containing them are useful for the treatment of inflammatory diseases and disorders such as for example pulmonary fibrosis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261661953P | 2012-06-20 | 2012-06-20 | |
PCT/EP2013/062463 WO2013189865A1 (en) | 2012-06-20 | 2013-06-17 | N-aryltriazole compounds as lpar antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN09352A true IN2014DN09352A (en) | 2015-07-17 |
Family
ID=48628669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN9352DEN2014 IN2014DN09352A (en) | 2012-06-20 | 2013-06-17 |
Country Status (22)
Country | Link |
---|---|
US (1) | US20150133512A1 (en) |
EP (1) | EP2864301A1 (en) |
JP (1) | JP2015520203A (en) |
KR (1) | KR20150011389A (en) |
CN (1) | CN104395299A (en) |
AU (1) | AU2013279513A1 (en) |
BR (1) | BR112014030674A2 (en) |
CA (1) | CA2869564A1 (en) |
CL (1) | CL2014003241A1 (en) |
CO (1) | CO7131357A2 (en) |
EA (1) | EA201492281A1 (en) |
HK (1) | HK1206339A1 (en) |
IL (1) | IL236087A0 (en) |
IN (1) | IN2014DN09352A (en) |
MA (1) | MA37762B1 (en) |
MX (1) | MX2014014711A (en) |
PE (1) | PE20142305A1 (en) |
PH (1) | PH12014502363A1 (en) |
SG (1) | SG11201407228PA (en) |
UA (1) | UA110310C2 (en) |
WO (1) | WO2013189865A1 (en) |
ZA (1) | ZA201408167B (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104066729A (en) | 2011-08-15 | 2014-09-24 | 英特穆恩公司 | Lysophosphatidic acid receptor antagonists |
TW201437200A (en) * | 2013-01-15 | 2014-10-01 | Intermune Inc | Lysophosphatidic acid receptor antagonists |
WO2014145873A2 (en) | 2013-03-15 | 2014-09-18 | Epigen Biosciences, Inc. | Heterocyclic compounds useful in the treatment of disease |
UY36060A (en) | 2014-04-02 | 2015-10-30 | Bayer Pharma AG | AZOL COMPOUNDS REPLACED WITH AMIDA |
CN106458964B (en) | 2014-06-27 | 2019-11-22 | 宇部兴产株式会社 | The salt of halogen substituted heterocyclic compound |
WO2017055316A1 (en) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Amido-substituted azole compounds |
WO2017055313A1 (en) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Amido-substituted azole compounds |
AR108838A1 (en) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | CARBAMOYLOXIMETHYL ACID TRIAZOL CYCLOHEXILO AS LPA ANTAGONISTS |
WO2018078005A1 (en) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Amido-substituted azaspiro derivatives as tankyrase inhibitors |
WO2018078009A1 (en) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Amido-substituted cyclohexane derivatives |
WO2018087126A1 (en) | 2016-11-09 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Amido-substituted cyclohexane derivatives as inhibitors of tankyrase |
CN107721984A (en) * | 2017-11-07 | 2018-02-23 | 大连理工大学 | A kind of preparation method of trisubstituted 1,2,3 triazole of new 5 amide groups 1,4,5 |
CN107827829A (en) * | 2017-11-07 | 2018-03-23 | 大连理工大学 | Preparation method of 5 amide groups, 1,4,5 trisubstituted 1,2,3 triazole in aqueous phase and Biomedia |
KR20200100753A (en) | 2017-12-19 | 2020-08-26 | 브리스톨-마이어스 스큅 컴퍼니 | Cyclohexyl acid pyrazole azole as an LPA antagonist |
US11261174B2 (en) | 2017-12-19 | 2022-03-01 | Bristol-Myers Squibb Company | Pyrazole O-linked carbamoyl cyclohexyl acids as LPA antagonists |
KR20200101957A (en) | 2017-12-19 | 2020-08-28 | 브리스톨-마이어스 스큅 컴퍼니 | Isoxazole O-linked carbamoyl cyclohexyl acid as LPA antagonist |
KR20200100722A (en) | 2017-12-19 | 2020-08-26 | 브리스톨-마이어스 스큅 컴퍼니 | Cyclohexyl acid isoxazole azine as an LPA antagonist |
CN112041304A (en) | 2017-12-19 | 2020-12-04 | 百时美施贵宝公司 | Isoxazole N-linked carbamoylcyclohexanoic acids as LPA antagonists |
US11319315B2 (en) | 2017-12-19 | 2022-05-03 | Bristol-Myers Squibb Company | Cyclohexyl acid triazole azoles as LPA antagonists |
JP7208240B2 (en) | 2017-12-19 | 2023-01-18 | ブリストル-マイヤーズ スクイブ カンパニー | Cyclohexylate triazole azines as LPA antagonists |
WO2019126087A1 (en) * | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azoles as lpa antagonists |
CN112055710A (en) | 2017-12-19 | 2020-12-08 | 百时美施贵宝公司 | Cyclohexyl acid pyrazole azines as LPA antagonists |
EA202091500A1 (en) | 2017-12-19 | 2020-09-14 | Бристол-Маерс Сквибб Компани | Pyrazole N-Bonded Carbamoylcyclohexyl Acids as LPA Antagonists |
CN111434653A (en) * | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | Triazole compound and preparation method and application thereof |
CA3158743A1 (en) | 2019-11-15 | 2021-05-20 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
US11702407B2 (en) | 2020-06-03 | 2023-07-18 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
TW202344504A (en) | 2020-06-03 | 2023-11-16 | 美商基利科學股份有限公司 | Lpa receptor antagonists and uses thereof |
US11939318B2 (en) | 2021-12-08 | 2024-03-26 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
CN115745848A (en) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | Processing and synthesizing process of aminoguanidine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011159550A2 (en) * | 2010-06-14 | 2011-12-22 | Amidra Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonist and uses thereof |
WO2011159633A1 (en) * | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Inhalable formulations of lysophosphatdic acid receptor antagonists |
AU2011338561A1 (en) * | 2010-12-07 | 2013-07-25 | Amira Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonists and their use in the treatment of fibrosis |
WO2012138648A1 (en) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
CN104066729A (en) * | 2011-08-15 | 2014-09-24 | 英特穆恩公司 | Lysophosphatidic acid receptor antagonists |
JP2015520202A (en) * | 2012-06-20 | 2015-07-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | N-alkyltriazole compounds as LPAR antagonists |
-
2013
- 2013-06-17 SG SG11201407228PA patent/SG11201407228PA/en unknown
- 2013-06-17 AU AU2013279513A patent/AU2013279513A1/en not_active Abandoned
- 2013-06-17 CA CA2869564A patent/CA2869564A1/en not_active Abandoned
- 2013-06-17 CN CN201380031806.0A patent/CN104395299A/en active Pending
- 2013-06-17 MX MX2014014711A patent/MX2014014711A/en unknown
- 2013-06-17 KR KR1020147035551A patent/KR20150011389A/en not_active Application Discontinuation
- 2013-06-17 BR BR112014030674A patent/BR112014030674A2/en not_active Application Discontinuation
- 2013-06-17 EP EP13729332.0A patent/EP2864301A1/en not_active Withdrawn
- 2013-06-17 EA EA201492281A patent/EA201492281A1/en unknown
- 2013-06-17 WO PCT/EP2013/062463 patent/WO2013189865A1/en active Application Filing
- 2013-06-17 JP JP2015517705A patent/JP2015520203A/en active Pending
- 2013-06-17 MA MA37762A patent/MA37762B1/en unknown
- 2013-06-17 US US14/403,261 patent/US20150133512A1/en not_active Abandoned
- 2013-06-17 UA UAA201500426A patent/UA110310C2/en unknown
- 2013-06-17 IN IN9352DEN2014 patent/IN2014DN09352A/en unknown
- 2013-06-17 PE PE2014002213A patent/PE20142305A1/en not_active Application Discontinuation
-
2014
- 2014-10-22 PH PH12014502363A patent/PH12014502363A1/en unknown
- 2014-11-07 ZA ZA2014/08167A patent/ZA201408167B/en unknown
- 2014-11-20 CO CO14255124A patent/CO7131357A2/en unknown
- 2014-11-28 CL CL2014003241A patent/CL2014003241A1/en unknown
- 2014-12-04 IL IL236087A patent/IL236087A0/en unknown
-
2015
- 2015-07-21 HK HK15106924.1A patent/HK1206339A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2013189865A1 (en) | 2013-12-27 |
PE20142305A1 (en) | 2015-01-16 |
UA110310C2 (en) | 2015-12-10 |
MA37762B1 (en) | 2018-04-30 |
MX2014014711A (en) | 2015-03-04 |
US20150133512A1 (en) | 2015-05-14 |
MA37762A1 (en) | 2017-07-31 |
ZA201408167B (en) | 2015-12-23 |
HK1206339A1 (en) | 2016-01-08 |
EP2864301A1 (en) | 2015-04-29 |
CA2869564A1 (en) | 2013-12-27 |
JP2015520203A (en) | 2015-07-16 |
AU2013279513A1 (en) | 2014-10-16 |
IL236087A0 (en) | 2015-02-01 |
BR112014030674A2 (en) | 2017-06-27 |
CN104395299A (en) | 2015-03-04 |
PH12014502363A1 (en) | 2015-01-12 |
EA201492281A1 (en) | 2015-04-30 |
CO7131357A2 (en) | 2014-12-01 |
KR20150011389A (en) | 2015-01-30 |
CL2014003241A1 (en) | 2015-03-20 |
SG11201407228PA (en) | 2014-12-30 |
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