EA201491613A1 - Катионные полимеры на основе гликогена - Google Patents

Катионные полимеры на основе гликогена

Info

Publication number
EA201491613A1
EA201491613A1 EA201491613A EA201491613A EA201491613A1 EA 201491613 A1 EA201491613 A1 EA 201491613A1 EA 201491613 A EA201491613 A EA 201491613A EA 201491613 A EA201491613 A EA 201491613A EA 201491613 A1 EA201491613 A1 EA 201491613A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cationic polymers
glycogen
polymers based
complexes
anionic compounds
Prior art date
Application number
EA201491613A
Other languages
English (en)
Other versions
EA032479B1 (ru
Inventor
Винченцо Руссо
Элиза Либерати
Никола Каццолла
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Publication of EA201491613A1 publication Critical patent/EA201491613A1/ru
Publication of EA032479B1 publication Critical patent/EA032479B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/18—Reserve carbohydrates, e.g. glycogen, inulin, laminarin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Настоящее изобретение относится к катионным полимерам на основе гликогена, комплексам указанных катионных полимеров с анионными соединениями, фармацевтическим композициям, содержащим указанные комплексы, и применению указанных комплексов для доставки или трансфекции указанных анионных соединений к определенной фармакологической мишени, такой как, например, орган, ткань или клетка.
EA201491613A 2012-03-15 2013-02-21 Катионные полимеры на основе гликогена EA032479B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12159710 2012-03-15
PCT/EP2013/053422 WO2013135471A1 (en) 2012-03-15 2013-02-21 Glycogen-based cationic polymers

Publications (2)

Publication Number Publication Date
EA201491613A1 true EA201491613A1 (ru) 2014-12-30
EA032479B1 EA032479B1 (ru) 2019-06-28

Family

ID=47739282

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491613A EA032479B1 (ru) 2012-03-15 2013-02-21 Катионные полимеры на основе гликогена

Country Status (29)

Country Link
US (1) US9717801B2 (ru)
EP (1) EP2825565B1 (ru)
JP (1) JP6247234B2 (ru)
KR (1) KR101997018B1 (ru)
CN (2) CN104080812B (ru)
AR (1) AR090307A1 (ru)
AU (1) AU2013231561B2 (ru)
BR (1) BR112014018617A8 (ru)
CA (1) CA2859273C (ru)
CY (1) CY1121829T1 (ru)
DK (1) DK2825565T3 (ru)
EA (1) EA032479B1 (ru)
ES (1) ES2732216T3 (ru)
GE (1) GEP201606581B (ru)
HK (1) HK1203984A1 (ru)
HR (1) HRP20191114T1 (ru)
HU (1) HUE045049T2 (ru)
IL (1) IL233823B (ru)
LT (1) LT2825565T (ru)
ME (1) ME03429B (ru)
MX (1) MX351599B (ru)
PL (1) PL2825565T3 (ru)
PT (1) PT2825565T (ru)
RS (1) RS58985B1 (ru)
SG (2) SG10201607577QA (ru)
SI (1) SI2825565T1 (ru)
TR (1) TR201909387T4 (ru)
UA (1) UA115135C2 (ru)
WO (1) WO2013135471A1 (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR095937A1 (es) 2013-04-05 2015-11-25 Acraf Potenciador de la solubilidad en agua a base de glucógeno
CN105491994A (zh) 2013-04-26 2016-04-13 奇迹连结生物技术公司 单分散性糖原和植物糖原纳米颗粒及其作为化妆品、药品、和食品产品中的添加剂的用途
US20180036409A1 (en) * 2014-12-29 2018-02-08 Bonac Corporation Composition containing nucleic acid molecule stably
CN104558246B (zh) * 2015-01-20 2017-03-01 武汉理工大学 一种叶酸/生物素修饰的壳聚糖材料及其制备方法
DE102015205088C5 (de) * 2015-03-20 2024-09-26 Kuka Deutschland Gmbh Verfahren zum Ermitteln eines Kalibrierungsparameters eines Fahrzeuges sowie Fahrzeug hierzu
JP6872782B2 (ja) * 2016-03-08 2021-05-19 国立大学法人京都大学 カチオン性グルカンナノスフェア、複合体、核酸導入剤及びがん治療剤
CA3020772A1 (en) * 2016-04-14 2017-10-19 Mirexus Biotechnologies Inc. Anti-infective compositions comprising phytoglycogen nanoparticles
AU2017260705A1 (en) * 2016-05-04 2018-11-22 Mirexus Biotechnologies Inc. Glycogen and phytoglycogen nanoparticles as immunosuppressive compounds, and compositions and methods of use thereof
CN105949344B (zh) * 2016-05-13 2019-05-17 中山大学 一种阳离子超支化多糖衍生物及其在增强血卟啉类光敏剂对肿瘤细胞光毒性方面的应用
WO2019027999A1 (en) * 2017-07-31 2019-02-07 Ohio State Innovation Foundation BIOMIMETIC NANOMATERIALS AND USES THEREOF
US11384161B2 (en) 2018-01-11 2022-07-12 Virginia Tech Intellectual Properties, Inc. Amphiphilic polysaccharides, polysaccharide-based hydrogels, and methods of manufacture

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GB8904370D0 (en) * 1989-02-25 1989-04-12 Cosmas Damian Ltd Liquid delivery compositions
IT1255488B (it) 1992-08-04 1995-11-06 Angelini Francesco Ist Ricerca Polisaccaridi del glicogeno
US7144713B1 (en) * 1995-10-02 2006-12-05 Emd Biosciences, Inc. Method for precipitating nucleic acid with visible carrier
GB9600272D0 (en) 1996-01-06 1996-03-06 Univ Nottingham Polymers
US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
WO2002100435A1 (en) 2001-06-11 2002-12-19 Centre Hospitalier Universitaire De Montreal Compositions and methods for enhancing nucleic acid transfer into cells
US20030147958A1 (en) 2002-01-29 2003-08-07 Cheol-Hee Ahn Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents
US20030186916A1 (en) 2002-03-12 2003-10-02 Lei Yu Vector for transfection of eukaryotic cells
JPWO2005094894A1 (ja) * 2004-03-31 2008-02-14 株式会社メドジェル 細胞に核酸を導入するための製剤
WO2007038769A1 (en) 2005-09-28 2007-04-05 Hetzel Adrian H Electro-hydraulic timed angle controlled joint simulation torque calibration, certification and analysis device
UA97559C2 (ru) * 2007-11-08 2012-02-27 Оцука Фармасьютікал Ко., Лтд. Комплекс нуклеиновой кислоты и композиция для доставки нуклеиновой кислоты
CN101235098A (zh) * 2008-01-09 2008-08-06 浙江大学 功能性植物多糖的修饰方法
CN102257115B (zh) * 2008-12-22 2013-02-06 荷兰联合利华有限公司 洗衣组合物
CN102257116B (zh) * 2008-12-22 2013-02-06 荷兰联合利华有限公司 洗衣组合物
WO2010128601A1 (ja) * 2009-05-08 2010-11-11 国立大学法人 鹿児島大学 グルクロン酸含有グルカン、その製造法および利用
EP2275085A1 (en) * 2009-07-07 2011-01-19 University of Rostock Biodegradable copolymer suitable for delivering nucleic acid materials into cells
CN102068698A (zh) * 2009-11-24 2011-05-25 深圳先进技术研究院 纳米疫苗及其制备方法

Also Published As

Publication number Publication date
CY1121829T1 (el) 2020-07-31
CA2859273C (en) 2020-04-14
EP2825565B1 (en) 2019-04-03
DK2825565T3 (da) 2019-06-24
IL233823A0 (en) 2014-09-30
WO2013135471A1 (en) 2013-09-19
US20140378532A1 (en) 2014-12-25
IL233823B (en) 2018-05-31
UA115135C2 (uk) 2017-09-25
TR201909387T4 (tr) 2019-07-22
CN104080812A (zh) 2014-10-01
BR112014018617A8 (pt) 2017-07-11
CN104080812B (zh) 2017-06-27
HK1203984A1 (en) 2015-11-06
KR101997018B1 (ko) 2019-07-05
SG10201607577QA (en) 2016-11-29
CN107236052A (zh) 2017-10-10
LT2825565T (lt) 2019-07-10
AU2013231561B2 (en) 2017-06-08
JP6247234B2 (ja) 2017-12-13
HUE045049T2 (hu) 2019-12-30
JP2015510020A (ja) 2015-04-02
US9717801B2 (en) 2017-08-01
AU2013231561A1 (en) 2014-07-10
MX351599B (es) 2017-10-20
SI2825565T1 (sl) 2019-08-30
SG11201403816YA (en) 2014-08-28
EA032479B1 (ru) 2019-06-28
PL2825565T3 (pl) 2019-10-31
HRP20191114T1 (hr) 2019-09-20
MX2014010698A (es) 2015-03-10
RS58985B1 (sr) 2019-08-30
EP2825565A1 (en) 2015-01-21
KR20150006414A (ko) 2015-01-16
PT2825565T (pt) 2019-07-10
ES2732216T3 (es) 2019-11-21
BR112014018617A2 (ru) 2017-06-20
ME03429B (me) 2020-01-20
CA2859273A1 (en) 2013-09-19
AR090307A1 (es) 2014-11-05
CN107236052B (zh) 2019-09-24
GEP201606581B (en) 2016-11-25

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU