MX2014008590A - Conjugados de antagonista de la integrina para suministro dirigido a celulas que expresan el antigeno 1 asociado a la funcion de linfocitos (lfa-1). - Google Patents

Conjugados de antagonista de la integrina para suministro dirigido a celulas que expresan el antigeno 1 asociado a la funcion de linfocitos (lfa-1).

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Publication number
MX2014008590A
MX2014008590A MX2014008590A MX2014008590A MX2014008590A MX 2014008590 A MX2014008590 A MX 2014008590A MX 2014008590 A MX2014008590 A MX 2014008590A MX 2014008590 A MX2014008590 A MX 2014008590A MX 2014008590 A MX2014008590 A MX 2014008590A
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Prior art keywords
cells expressing
targeted delivery
integrin antagonist
lfa
expressing lfa
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MX2014008590A
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English (en)
Inventor
Matthew Michael Hamilton
Achyutharao Sidduri
Agnieszka Kowalczyk
Robert Alan Goodnow Jr
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Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014008590A publication Critical patent/MX2014008590A/es

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    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

La presente invención se refiere a compuestos de la fórmula I: en donde R1, R2, y n se definen en la descripción detallada y las reivindicaciones. En particular, la presente invención se refiere a los compuestos de la fórmula I para uso en la fabricación y suministro de porciones conjugadas tales como moléculas pequeñas, péptidos, ácidos nucleicos, porciones fluorescentes, y polímeros las cuales se enlazan a antagonistas de la integrina LFA-1 a las células objetivo que expresan LFA-1.
MX2014008590A 2012-01-27 2013-01-24 Conjugados de antagonista de la integrina para suministro dirigido a celulas que expresan el antigeno 1 asociado a la funcion de linfocitos (lfa-1). MX2014008590A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591297P 2012-01-27 2012-01-27
US201261678673P 2012-08-02 2012-08-02
PCT/EP2013/051273 WO2013110679A1 (en) 2012-01-27 2013-01-24 Integrin antagonist conjugates for targeted delivery to cells expressing lfa-1

Publications (1)

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MX2014008590A true MX2014008590A (es) 2015-03-03

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MX2014008590A MX2014008590A (es) 2012-01-27 2013-01-24 Conjugados de antagonista de la integrina para suministro dirigido a celulas que expresan el antigeno 1 asociado a la funcion de linfocitos (lfa-1).

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US (2) US9650363B2 (es)
EP (1) EP2806897B1 (es)
JP (1) JP6182542B2 (es)
KR (1) KR20140121453A (es)
CN (1) CN104185478B (es)
BR (1) BR112014017517A2 (es)
CA (1) CA2857127A1 (es)
DK (1) DK2806897T3 (es)
HK (1) HK1202425A1 (es)
MX (1) MX2014008590A (es)
RU (1) RU2624732C2 (es)
WO (1) WO2013110679A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9650363B2 (en) * 2012-01-27 2017-05-16 Hoffmann-La Roche Inc. Integrin antagonist conjugates for targeted delivery to cells expressing LFA-1
US9447035B2 (en) * 2012-01-27 2016-09-20 Hoffmann-La Roche Inc. Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4
CN111825622A (zh) * 2020-07-10 2020-10-27 西华大学 一种氧化脱氢芳构化制备2-嘧啶酮衍生物的方法
CN115028828B (zh) * 2022-07-19 2023-09-15 西安超磁纳米生物科技有限公司 一种可靶向肝细胞的聚乙二醇衍生物及其制备方法

Family Cites Families (12)

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NZ502813A (en) * 1997-08-22 2002-10-25 F N-aroylphenylalanine derivatives as inhibitors of the interaction between a4 containing integrins and VCAM-1
US6229011B1 (en) * 1997-08-22 2001-05-08 Hoffman-La Roche Inc. N-aroylphenylalanine derivative VCAM-1 inhibitors
EP1403247A1 (en) * 1997-08-22 2004-03-31 F.Hoffmann-La Roche Ag N-Alkanoylphenylalanine derivatives
US6331640B1 (en) * 1998-10-13 2001-12-18 Hoffmann-La Roche Inc. Diaminopropionic acid derivatives
US6515124B2 (en) 2000-02-09 2003-02-04 Hoffman-La Roche Inc. Dehydroamino acids
US6774116B2 (en) * 2001-04-17 2004-08-10 Cryolife, Inc. Prodrugs via acylation with cinnamate
DK2444079T3 (en) * 2005-05-17 2017-01-30 Sarcode Bioscience Inc Compositions and Methods for the Treatment of Eye Diseases
PL2350043T3 (pl) 2008-10-09 2014-09-30 Tekmira Pharmaceuticals Corp Ulepszone aminolipidy i sposoby dostarczania kwasów nukleinowych
JP6126997B2 (ja) * 2011-02-16 2017-05-10 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 検出可能な標識の標的限局性の係留のための方法及び組成物
US20120270875A1 (en) * 2011-03-16 2012-10-25 Paul Gillespie Pyrimidine amide compounds
MX2014008373A (es) * 2012-01-27 2014-09-26 Hoffmann La Roche Conjugados antagonistas de integrina para suministro dirigido a celulas que expresan alfa-v-beta-3.
US9650363B2 (en) * 2012-01-27 2017-05-16 Hoffmann-La Roche Inc. Integrin antagonist conjugates for targeted delivery to cells expressing LFA-1

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US20150065534A1 (en) 2015-03-05
US9650363B2 (en) 2017-05-16
HK1202425A1 (en) 2015-10-02
WO2013110679A1 (en) 2013-08-01
RU2624732C2 (ru) 2017-07-06
EP2806897A1 (en) 2014-12-03
CN104185478A (zh) 2014-12-03
RU2014132837A (ru) 2016-03-20
BR112014017517A2 (pt) 2017-06-13
CN104185478B (zh) 2016-10-12
US20130197059A1 (en) 2013-08-01
JP6182542B2 (ja) 2017-08-16
EP2806897B1 (en) 2017-08-02
KR20140121453A (ko) 2014-10-15
DK2806897T3 (en) 2017-10-16
CA2857127A1 (en) 2013-08-01
JP2015508055A (ja) 2015-03-16

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