EA201491364A1 - Новые гетероариламидные производные, обладающие антиандрогенными свойствами - Google Patents
Новые гетероариламидные производные, обладающие антиандрогенными свойствамиInfo
- Publication number
- EA201491364A1 EA201491364A1 EA201491364A EA201491364A EA201491364A1 EA 201491364 A1 EA201491364 A1 EA 201491364A1 EA 201491364 A EA201491364 A EA 201491364A EA 201491364 A EA201491364 A EA 201491364A EA 201491364 A1 EA201491364 A1 EA 201491364A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- new
- heteroarilamide
- formula
- androgenic properties
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение относится к новым гетероариламидным производным, имеющим формулу (I)и N-оксидам, стереоизомерам и их фармацевтически приемлемым солям, в которых R, R, R, R', R", z и X определены в формуле изобретения. Ариламидные производные формулы (I) обладают антиандрогенными свойствами. Изобретение также относится к соединениям формулы (I) для применения в качестве лекарственного препарата и к включающим их фармацевтическим композициям и их получению.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20125039 | 2012-01-13 | ||
| PCT/FI2013/050027 WO2013104830A1 (en) | 2012-01-13 | 2013-01-11 | Novel heteroarylamide derivatives having antiandrogenic properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201491364A1 true EA201491364A1 (ru) | 2014-11-28 |
| EA029007B1 EA029007B1 (ru) | 2018-01-31 |
Family
ID=47683784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201491364A EA029007B1 (ru) | 2012-01-13 | 2013-01-11 | Новые гетероариламидные производные, обладающие антиандрогенными свойствами |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9650382B2 (ru) |
| EP (1) | EP2802563B1 (ru) |
| JP (1) | JP6234376B2 (ru) |
| KR (1) | KR102058886B1 (ru) |
| CN (1) | CN104066717B (ru) |
| AR (1) | AR089702A1 (ru) |
| AU (1) | AU2013208847B2 (ru) |
| BR (1) | BR112014016896B1 (ru) |
| CA (1) | CA2861713C (ru) |
| DK (1) | DK2802563T3 (ru) |
| EA (1) | EA029007B1 (ru) |
| ES (1) | ES2640119T3 (ru) |
| HK (1) | HK1201838A1 (ru) |
| MX (1) | MX356499B (ru) |
| NZ (1) | NZ626715A (ru) |
| PL (1) | PL2802563T3 (ru) |
| SG (1) | SG11201404053RA (ru) |
| TW (1) | TWI635080B (ru) |
| WO (1) | WO2013104830A1 (ru) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0100172B1 (en) | 1982-07-23 | 1987-08-12 | Imperial Chemical Industries Plc | Amide derivatives |
| ATE440817T1 (de) | 2001-12-13 | 2009-09-15 | Sumitomo Chemical Co | Bicalutamidkristalle und verfahren zu deren herstellung |
| US7741371B2 (en) | 2002-06-17 | 2010-06-22 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| WO2004041277A1 (en) * | 2002-11-01 | 2004-05-21 | Merck & Co., Inc. | Carbonylamino-benzimidazole derivatives as androgen receptor modulators |
| US20090156614A1 (en) | 2006-07-19 | 2009-06-18 | Dalton James T | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof |
| US8461343B2 (en) | 2007-03-27 | 2013-06-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| DE102007058747A1 (de) | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| ITBO20090078A1 (it) | 2009-02-13 | 2010-08-14 | Consiglio Nazionale Ricerche | Composti per il trattamento del tumore alla prostata e procedimenti per la loro sintesi |
| EP2424853B1 (en) * | 2009-04-10 | 2018-09-19 | Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori (I.R.S.T.) S.R.L. | Non-steroidal compounds for androgen receptor modulation, processes for the preparation and uses thereof |
| PT3124481T (pt) | 2010-02-16 | 2018-06-18 | Aragon Pharmaceuticals Inc | Moduladores do receptor de androgénios e suas utilizações |
| FR2982261B1 (fr) | 2011-11-04 | 2014-06-13 | Galderma Res & Dev | Nouveaux amides, et leur utilisation pharmaceutique ou cosmetique |
-
2013
- 2013-01-11 PL PL13703633T patent/PL2802563T3/pl unknown
- 2013-01-11 EP EP13703633.1A patent/EP2802563B1/en active Active
- 2013-01-11 WO PCT/FI2013/050027 patent/WO2013104830A1/en active Application Filing
- 2013-01-11 NZ NZ626715A patent/NZ626715A/en unknown
- 2013-01-11 TW TW102101023A patent/TWI635080B/zh active
- 2013-01-11 EA EA201491364A patent/EA029007B1/ru not_active IP Right Cessation
- 2013-01-11 ES ES13703633.1T patent/ES2640119T3/es active Active
- 2013-01-11 AU AU2013208847A patent/AU2013208847B2/en active Active
- 2013-01-11 AR ARP130100090A patent/AR089702A1/es active IP Right Grant
- 2013-01-11 KR KR1020147022538A patent/KR102058886B1/ko active IP Right Grant
- 2013-01-11 DK DK13703633.1T patent/DK2802563T3/en active
- 2013-01-11 MX MX2014008524A patent/MX356499B/es active IP Right Grant
- 2013-01-11 CN CN201380005365.7A patent/CN104066717B/zh active Active
- 2013-01-11 SG SG11201404053RA patent/SG11201404053RA/en unknown
- 2013-01-11 CA CA2861713A patent/CA2861713C/en active Active
- 2013-01-11 JP JP2014551659A patent/JP6234376B2/ja active Active
- 2013-01-11 BR BR112014016896-2A patent/BR112014016896B1/pt active IP Right Grant
- 2013-01-11 US US14/371,927 patent/US9650382B2/en active Active
-
2015
- 2015-03-10 HK HK15102462.8A patent/HK1201838A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014008524A (es) | 2014-08-21 |
| KR20140117531A (ko) | 2014-10-07 |
| CA2861713C (en) | 2021-08-31 |
| JP6234376B2 (ja) | 2017-11-22 |
| BR112014016896B1 (pt) | 2021-08-17 |
| EP2802563A1 (en) | 2014-11-19 |
| HK1201838A1 (en) | 2015-09-11 |
| AU2013208847A1 (en) | 2014-08-14 |
| TW201332974A (zh) | 2013-08-16 |
| PL2802563T3 (pl) | 2017-11-30 |
| NZ626715A (en) | 2016-07-29 |
| CA2861713A1 (en) | 2013-07-18 |
| SG11201404053RA (en) | 2014-10-30 |
| JP2015504892A (ja) | 2015-02-16 |
| ES2640119T3 (es) | 2017-10-31 |
| BR112014016896A8 (pt) | 2017-07-04 |
| CN104066717A (zh) | 2014-09-24 |
| DK2802563T3 (en) | 2017-09-18 |
| EP2802563B1 (en) | 2017-06-07 |
| US9650382B2 (en) | 2017-05-16 |
| EA029007B1 (ru) | 2018-01-31 |
| KR102058886B1 (ko) | 2019-12-24 |
| MX356499B (es) | 2018-05-30 |
| US20150005308A1 (en) | 2015-01-01 |
| BR112014016896A2 (pt) | 2017-06-13 |
| CN104066717B (zh) | 2019-07-30 |
| AU2013208847B2 (en) | 2017-08-31 |
| AR089702A1 (es) | 2014-09-10 |
| WO2013104830A1 (en) | 2013-07-18 |
| TWI635080B (zh) | 2018-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG TJ TM |