EA201290056A1 - Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности - Google Patents

Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности

Info

Publication number
EA201290056A1
EA201290056A1 EA201290056A EA201290056A EA201290056A1 EA 201290056 A1 EA201290056 A1 EA 201290056A1 EA 201290056 A EA201290056 A EA 201290056A EA 201290056 A EA201290056 A EA 201290056A EA 201290056 A1 EA201290056 A1 EA 201290056A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kidney damage
compositions
methods
prediction
diagnosis
Prior art date
Application number
EA201290056A
Other languages
English (en)
Russian (ru)
Inventor
Джозеф Андерберг
Джефф Грей
Пол Макферсон
Кевин Накамура
Original Assignee
Астьют Медикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астьют Медикал, Инк. filed Critical Астьют Медикал, Инк.
Publication of EA201290056A1 publication Critical patent/EA201290056A1/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4728—Details alpha-Glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
EA201290056A 2009-08-07 2010-08-06 Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности EA201290056A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23229309P 2009-08-07 2009-08-07
PCT/US2010/044772 WO2011017654A1 (en) 2009-08-07 2010-08-06 Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Publications (1)

Publication Number Publication Date
EA201290056A1 true EA201290056A1 (ru) 2012-08-30

Family

ID=43544696

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290056A EA201290056A1 (ru) 2009-08-07 2010-08-06 Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности

Country Status (12)

Country Link
US (2) US8871459B2 (enExample)
EP (1) EP2462440B1 (enExample)
JP (1) JP5827226B2 (enExample)
KR (1) KR20120061863A (enExample)
CN (1) CN102576011B (enExample)
AU (1) AU2010279249B2 (enExample)
BR (1) BR112012002711A2 (enExample)
CA (1) CA2770393A1 (enExample)
EA (1) EA201290056A1 (enExample)
MX (1) MX336280B (enExample)
NZ (1) NZ598034A (enExample)
WO (1) WO2011017654A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9229010B2 (en) * 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BR112012002711A2 (pt) * 2009-08-07 2016-11-01 Astute Medical Inc metodo para avaliar o estado renal em um individuo, e, medicao de proteina
EP2585827A4 (en) 2010-06-23 2013-12-04 Astute Medical Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency
BR112014004389A2 (pt) * 2011-08-26 2017-03-28 Astute Medical Inc métodos e composições para diagnóstico de lesão renal e insuficiência renal
EP3182126A3 (en) * 2012-06-15 2017-08-02 Wayne State University Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome
CN104122355B (zh) * 2014-07-14 2017-01-18 山东省科学院生物研究所 一种通过检测斑马鱼组织肌酐含量评价化合物肾脏毒性的方法
US11346846B2 (en) 2017-02-06 2022-05-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US10837970B2 (en) 2017-09-01 2020-11-17 Venn Biosciences Corporation Identification and use of glycopeptides as biomarkers for diagnosis and treatment monitoring
KR20210019459A (ko) 2018-05-24 2021-02-22 레니버스 테라퓨틱스, 인크. 신장 손상 및 신부전 위험이 있는 환자를 치료하는 방법
CN112710640A (zh) * 2019-10-25 2021-04-27 上海交通大学 基于表皮角蛋白及片段含量评估血清中白介素水平的方法
CN113252806B (zh) * 2021-03-25 2023-08-29 嘉兴学院 S-腺苷同型半胱氨酸在制备用于诊断或治疗川崎病的产品中的用途

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1429031A1 (ru) 1986-06-20 1988-10-07 Калининский Государственный Медицинский Институт Способ дифференциальной диагностики гломерулонефрита и пиелонефрита
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
FI922164L (fi) 1990-09-14 1992-05-13 Biosite Diagnostics Inc Antikroppar mot komplex av ligandreceptorer och ligander och anvaendningen daerav vid bestaemning av ligandreceptorer.
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
WO1992018866A1 (en) 1991-04-10 1992-10-29 Biosite Diagnostics Incorporated Novel conjugates and assays for simultaneous detection of multiple ligands
EP0585310B1 (en) 1991-04-10 1999-03-17 Biosite Diagnostics Inc. Crosstalk inhibitors and their uses
AU1673292A (en) * 1991-04-24 1992-12-21 Yamasa Shoyu Kabushiki Kaisha Monoclonal antibody against human beta 2-glycoprotein i and use thereof
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US5494829A (en) 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
ES2258793T5 (es) 1996-05-24 2010-01-25 Biogen Idec Ma Inc. Moduladores de la regeneracion tisular.
US5753455A (en) 1996-09-03 1998-05-19 Bayer Corporation Method for the detection of lysozyme using a protein error indicator dye in conjunction with an alkane sulfonic acid
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
CA2293296A1 (en) 1997-06-03 1998-12-10 Sagami Chemical Research Center Human proteins having transmembrane domains and dnas encoding these proteins
US20060223077A1 (en) 1997-06-06 2006-10-05 Human Genome Sciences, Inc. 207 human secreted proteins
US6218122B1 (en) 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
US6958147B1 (en) 1998-10-26 2005-10-25 Licentia Ltd Use of VEGF-C to prevent restenosis
BR9916407A (pt) * 1998-12-21 2001-09-25 Univ Monash Detecção e tratamento de doenças dos rins
RU2180965C1 (ru) 2000-07-03 2002-03-27 Габбасова Наталья Вадимовна Способ дифференциальной диагностики заболеваний почек
AU2002216273A1 (en) 2000-12-29 2002-07-16 Oxford Glycosciences (Uk) Limited Proteins, genes and their use for diagnosis and treatment of kidney response
CA2442820A1 (en) 2001-03-29 2002-10-10 Van Andel Institute Microarray gene expression profiling in clear cell renal cell carcinoma: prognosis and drug target identification
US20070015146A1 (en) 2001-05-22 2007-01-18 Gene Logic, Inc. Molecular nephrotoxicology modeling
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20030003588A1 (en) 2001-06-28 2003-01-02 Comper Wayne D. Method for kidney disease detection by protein profiling
US7214373B2 (en) 2001-07-24 2007-05-08 Yale University Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease
US6784154B2 (en) 2001-11-01 2004-08-31 University Of Utah Research Foundation Method of use of erythropoietin to treat ischemic acute renal failure
US8404229B2 (en) 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
GB0130557D0 (en) 2001-12-20 2002-02-06 Serono Internat S A Proteins
CA2478288A1 (en) 2002-03-07 2003-09-12 Adrian Woolfson Scd fingerprints
AU2003214604A1 (en) 2002-03-21 2003-10-08 Hadasit Medical Research Services And Development Ltd. Peripheral blood cell markers useful for diagnosing multiple sclerosis and methods and kits utilizing same
US7138229B2 (en) 2002-12-06 2006-11-21 Renovar, Inc. Systems and methods for characterizing kidney diseases
US7138230B2 (en) 2002-12-06 2006-11-21 Renovar, Inc. Systems and methods for characterizing kidney diseases
AU2003281287A1 (en) 2002-07-04 2004-01-23 Oxford Glycosciences (Uk) Ltd Toxicity markers
EP1548436B1 (en) * 2002-09-06 2008-11-19 Eiji Matsuura Method of assaying oxidized ldl-beta 2-glycoprotein i complex in vivo
US6941172B2 (en) 2002-11-18 2005-09-06 Zvi Nachum Method and device for restoring kidney function using electromagnetic stimulation
WO2004053074A2 (en) 2002-12-06 2004-06-24 Science And Technology Corporation @ Unm Outcome prediction and risk classification in childhood leukemia
CN1791797A (zh) 2003-03-27 2006-06-21 儿童医院医疗中心 用于检测肾小管细胞损伤的早发的方法和试剂盒
KR101224235B1 (ko) 2003-04-11 2013-01-25 메디뮨 엘엘씨 재조합 ｉｌ­９ 항체 및 그의 용도
WO2005002416A2 (en) 2003-06-04 2005-01-13 Joslin Diabetes Center, Inc. Predictors of renal disease
US20050148029A1 (en) 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
GB0329288D0 (en) 2003-12-18 2004-01-21 Inverness Medical Switzerland Monitoring method and apparatus
EP1727564A1 (en) 2004-03-17 2006-12-06 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Cd44-targeting for reducing/preventing ischemia-reperfusion-injury
EP1743031A4 (en) 2004-04-26 2008-05-28 Childrens Medical Center BLOOD PLATE BIOMARKERS FOR THE DETECTION OF ILLNESSES
US20050272101A1 (en) 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
US7588892B2 (en) 2004-07-19 2009-09-15 Entelos, Inc. Reagent sets and gene signatures for renal tubule injury
WO2006008661A2 (en) 2004-07-19 2006-01-26 Neurochem (International) Limited Diagnostic methods of multiple organ amyloidosis
US7141382B1 (en) 2004-10-12 2006-11-28 Parikh Chirag R Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality
EP1846576A4 (en) 2005-02-01 2009-01-07 Us Gov Health & Human Serv BIOMARKERS OF TISSUE STATUS
EP2604703B1 (en) 2005-03-14 2017-02-01 The Board of Trustees of the Leland Stanford Junior University Methods for evaluating graft survival in a solid organ transplant recipient
US7608413B1 (en) 2005-03-25 2009-10-27 Celera Corporation Kidney disease targets and uses thereof
US20070037232A1 (en) 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
CA2792443A1 (en) 2005-04-18 2006-10-26 Ryan Parr Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
US20070087387A1 (en) 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
WO2007013919A2 (en) 2005-07-21 2007-02-01 The Johns Hopkins University Methods of detecting and treating acute kidney injury
US7759077B2 (en) 2005-08-02 2010-07-20 Shariat Shahrokh F Soluble fas urinary marker for the detection of bladder transitional cell carcinoma
EP1757940A1 (en) 2005-08-26 2007-02-28 Cézanne S.A.S. In vitro method for diagnosing and monitoring renal cell carcinoma (RCC) using MMP-7 as humoral biomarker for RCC
EP1931990A4 (en) 2005-10-03 2010-03-10 Biosite Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND / OR FORECASTING IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROMES
US20080090304A1 (en) 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
US8329408B2 (en) 2005-10-31 2012-12-11 Bayer Healthcare Llc Methods for prognosis and monitoring cancer therapy
US10716749B2 (en) 2005-11-03 2020-07-21 Palo Alto Investors Methods and compositions for treating a renal disease condition in a subject
US20080133141A1 (en) 2005-12-22 2008-06-05 Frost Stephen J Weighted Scoring Methods and Use Thereof in Screening
TW200726845A (en) 2006-01-02 2007-07-16 Nat Defense Medical Ct Biomarker molecular of renal illness and detecting method for the same
GB0605217D0 (en) 2006-03-15 2006-04-26 Novartis Ag Method and compositions for assessing acute rejection
GB0606776D0 (en) 2006-04-03 2006-05-10 Novartis Pharma Ag Predictive biomarkers for chronic allograft nephropathy
US7662578B2 (en) 2006-04-21 2010-02-16 Children's Hospital Medical Center Method and kit for the early detection of impaired renal status
US20080038269A1 (en) 2006-05-25 2008-02-14 Mount Sinai Hospital Methods for detecting and treating kidney disease
WO2008084331A2 (en) 2006-06-21 2008-07-17 Hopitaux Universitaires De Geneve Biomarkers for renal disorders
WO2008005375A2 (en) 2006-06-30 2008-01-10 Merck & Co., Inc. Kidney toxicity biomarkers
US20090176656A1 (en) 2006-07-21 2009-07-09 Halloran Philip F Tissue rejection
GB0617429D0 (en) * 2006-09-05 2006-10-18 Electrophoretics Ltd Markers of renal transplant rejection and renal damage
US20080206794A1 (en) 2006-09-15 2008-08-28 Renovar Incorporated Systems And Methods For Characterizing Contrast Induced-Nephropathy
EP2095107B1 (en) 2006-11-14 2014-07-02 Alere San Diego, Inc. Methods for risk assignment
EP2064550B1 (en) 2006-12-08 2015-02-25 The Children's Hospital Of Philadelphia Use of prrg4 in methods of tumor diagnosis
GB0701626D0 (en) 2007-01-22 2007-03-07 Cambridge Entpr Ltd Methods and biomarkers for diagnosing and monitoring psychotic disorders
WO2008104803A2 (en) 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
JP5229789B2 (ja) * 2007-02-27 2013-07-03 プリマハム株式会社 新規ストレスバイオマーカー及びその用途
US8221995B2 (en) 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
WO2008116867A1 (en) 2007-03-26 2008-10-02 Novartis Ag Predictive renal safety biomarkers and biomarker signatures to monitor kidney function
CA2682538A1 (en) 2007-04-10 2008-10-16 Integragen Human diabetes susceptibility tnfrsf10b gene
US8080394B2 (en) 2007-04-27 2011-12-20 Brigham And Women's Hospital Method for determining predisposition to pulmonary infection
US9091695B2 (en) 2007-06-01 2015-07-28 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
JP5661457B2 (ja) 2007-06-06 2015-01-28 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 腎疾患の予測診断
US20090047689A1 (en) 2007-06-20 2009-02-19 John Kolman Autoantigen biomarkers for early diagnosis of lung adenocarcinoma
US20100267041A1 (en) 2007-09-14 2010-10-21 Predictive Biosciences, Inc. Serial analysis of biomarkers for disease diagnosis
US8039227B2 (en) 2007-09-20 2011-10-18 University Of Louisville Research Foundation, Inc. Peptide biomarkers predictive of renal function decline and kidney disease
WO2009038742A2 (en) 2007-09-20 2009-03-26 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Method for estimating risk of acute kidney injury
US8003333B2 (en) * 2007-09-28 2011-08-23 Mayo Foundation For Medical Education And Research Serum biomarkers for early detection of acute cellular rejection
BRPI0907802A2 (pt) 2008-02-29 2016-08-23 Univ Nagoya Nat Univ Corp biomarcador para lesão renal aguda e estimativa de seu prognóstico, e sua aplicação
US20090298106A1 (en) 2008-05-30 2009-12-03 Therapeutic Monitoring Services, L.L.C. Methods for Monitoring Immunosuppressant Drug Levels, Renal Function, and Hepatic Function Using Small Volume Samples
US8241861B1 (en) 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease
US7998744B2 (en) 2008-07-28 2011-08-16 Greenwood Genetic Center, Inc. Methods for determining dysregulation of methylation of brain expressed genes on the X chromosome to diagnose autism spectrum disorders
US8673574B2 (en) 2008-08-21 2014-03-18 Pxbiosciences Llc Diagnosis and monitoring of renal failure using peptide biomarkers
EP2324355B1 (en) 2008-08-28 2014-01-22 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2813848A3 (en) 2008-08-29 2015-03-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US8501489B2 (en) 2008-09-26 2013-08-06 University of Pittsburgh—of the Commonwealth System of Higher Education Urinary biomarkers to predict long-term dialysis
JP2012506538A (ja) 2008-10-21 2012-03-15 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
CA2740788C (en) 2008-10-21 2023-03-14 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104330574B (zh) 2008-11-10 2017-04-12 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
US9229010B2 (en) * 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2010091236A1 (en) 2009-02-06 2010-08-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and failure
AU2010230855A1 (en) 2009-04-03 2012-01-12 Vegenics Limited Anti-VEGF-D antibodies
ES2656232T3 (es) 2009-05-08 2018-02-26 Novartis Ag Métodos de modulación de fibrosis usando moduladores de la proteína morfogenética ósea 9 (BMP-9)
BR112012002711A2 (pt) * 2009-08-07 2016-11-01 Astute Medical Inc metodo para avaliar o estado renal em um individuo, e, medicao de proteina
US20110065593A1 (en) 2009-08-07 2011-03-17 Rules-Based Medicine, Inc. Computer Methods and Devices for Detecting Kidney Damage
AU2010295287B2 (en) 2009-09-21 2014-09-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2818138T3 (es) 2009-12-20 2021-04-09 Astute Medical Inc Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
US20120329071A1 (en) * 2010-03-05 2012-12-27 Mark Chance Protein biomarkers and therapeutic targets for renal disorders
EP2593794A4 (en) * 2010-07-14 2014-03-26 Astute Medical Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency
US20130035290A1 (en) 2011-05-17 2013-02-07 Yale University Chitinase-3-Like Protein 1 as a Biomarker of Recovery from Kidney Injury

Also Published As

Publication number Publication date
MX336280B (es) 2016-01-13
CN102576011A (zh) 2012-07-11
EP2462440A4 (en) 2013-01-02
AU2010279249B2 (en) 2015-08-13
EP2462440A1 (en) 2012-06-13
HK1167888A1 (en) 2012-12-14
BR112012002711A2 (pt) 2016-11-01
US20120264629A1 (en) 2012-10-18
US9366683B2 (en) 2016-06-14
MX2012001559A (es) 2012-07-17
AU2010279249A1 (en) 2012-03-01
CN102576011B (zh) 2014-09-17
JP5827226B2 (ja) 2015-12-02
KR20120061863A (ko) 2012-06-13
US8871459B2 (en) 2014-10-28
EP2462440B1 (en) 2017-05-17
NZ598034A (en) 2014-06-27
CA2770393A1 (en) 2011-02-10
JP2013501920A (ja) 2013-01-17
WO2011017654A1 (en) 2011-02-10
US20150044706A1 (en) 2015-02-12

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