EA201270365A1 - Молекулы анти-gcc антитела и соответствующие композиции и способы - Google Patents

Молекулы анти-gcc антитела и соответствующие композиции и способы

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EA201270365A1
EA201270365A1 EA201270365A EA201270365A EA201270365A1 EA 201270365 A1 EA201270365 A1 EA 201270365A1 EA 201270365 A EA201270365 A EA 201270365A EA 201270365 A EA201270365 A EA 201270365A EA 201270365 A1 EA201270365 A1 EA 201270365A1
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antibodies
gcc
antigen
methods
related compositions
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EA201270365A
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English (en)
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EA030827B1 (ru
Inventor
Самьюэл С. Нам
Эдвард А. Гринфилд
Джон Бабкук
Тереза О'Киф
Шисинь Цин
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Милленниум Фармасьютикалз, Инк.
Эмджен Бритиш Коламбиа
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Publication of EA201270365A1 publication Critical patent/EA201270365A1/ru
Publication of EA030827B1 publication Critical patent/EA030827B1/ru

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Abstract

Описаны антитела и антигенсвязывающие фрагменты антител, которые связывают GCC. Антитела связывают внеклеточный домен GCC и могут интернализоваться. В некоторых вариантах осуществления антитела являются гуманизированными, химерными или человеческими. Также описаны нуклеиновые кислоты и векторы, кодирующие антитела или их части, рекомбинантные клетки, которые содержат нуклеиновые кислоты, и композиции, содержащие антитела или антигенсвязывающие фрагменты. Изобретение также обеспечивает терапевтические и диагностические способы с использованием антител и антигенсвязывающих фрагментов, раскрытых в настоящей заявке.
EA201270365A 2009-10-23 2010-10-22 Анти-gcc антитело и его применения EA030827B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25447409P 2009-10-23 2009-10-23
PCT/US2010/053686 WO2011050242A1 (en) 2009-10-23 2010-10-22 Anti-gcc antibody molecules and related compositions and methods

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EA201270365A1 true EA201270365A1 (ru) 2012-09-28
EA030827B1 EA030827B1 (ru) 2018-10-31

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EA201270365A EA030827B1 (ru) 2009-10-23 2010-10-22 Анти-gcc антитело и его применения
EA201792376A EA201792376A3 (ru) 2009-10-23 2010-10-22 Молекулы анти-gcc антитела и соответствующие композиции и способы

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US (3) US8785600B2 (ru)
EP (2) EP3520816B1 (ru)
JP (2) JP5925684B2 (ru)
KR (2) KR20170123723A (ru)
CN (3) CN102573908B (ru)
AR (1) AR078751A1 (ru)
AU (1) AU2010310545C1 (ru)
BR (1) BR112012007523A2 (ru)
CA (2) CA2774032C (ru)
CL (1) CL2012000806A1 (ru)
CR (1) CR20120124A (ru)
DO (1) DOP2012000066A (ru)
EA (2) EA030827B1 (ru)
EC (1) ECSP12011761A (ru)
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GE (2) GEP20196956B (ru)
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