EA201200604A1 - Фармацевтические субстанции на основе митохондриальноадресованных антиоксидантов - Google Patents

Фармацевтические субстанции на основе митохондриальноадресованных антиоксидантов

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Publication number
EA201200604A1
EA201200604A1 EA201200604A EA201200604A EA201200604A1 EA 201200604 A1 EA201200604 A1 EA 201200604A1 EA 201200604 A EA201200604 A EA 201200604A EA 201200604 A EA201200604 A EA 201200604A EA 201200604 A1 EA201200604 A1 EA 201200604A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical substances
mitochondrial
basis
substances
mitochondria
Prior art date
Application number
EA201200604A
Other languages
English (en)
Other versions
EA023248B1 (ru
Inventor
Максим Владимирович СКУЛАЧЕВ
Владимир Петрович СКУЛАЧЕВ
Андрей Александрович ЗАМЯТИН
Евгений Степанович ЕФРЕМОВ
Вадим Неронович ТАШЛИЦКИЙ
Лев Сергеевич ЯГУЖИНСКИЙ
Галина Анатольевна КОРШУНОВА
Наталья Владимировна СУМБАТЯН
Юрий Николаевич Антоненко
Инна Исааковна СЕВЕРИНА
Борис Викторович ЧЕРНЯК
Original Assignee
Общество С Ограниченной Ответственностью "Митотех"
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Publication date
Application filed by Общество С Ограниченной Ответственностью "Митотех" filed Critical Общество С Ограниченной Ответственностью "Митотех"
Publication of EA201200604A1 publication Critical patent/EA201200604A1/ru
Publication of EA023248B1 publication Critical patent/EA023248B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/02—Quinones with monocyclic quinoid structure
    • C07C50/04—Benzoquinones, i.e. C6H4O2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/12—Naphthoquinones, i.e. C10H6O2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G01N33/5079—Mitochondria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)

Abstract

Данное изобретение относится к области фармацевтики, медицины и, в частности, касается получения и использования фармацевтических субстанций на основе митохондриальноадресованных соединений. Изобретение раскрывает способы синтеза, очистки и хранения митохондриальноадресованных антиоксидантов, позволяющих получать эти вещества в виде и качестве, соответствующим требованиям, предъявляемым к действующим веществам лекарственных препаратов - фармацевтическим субстанциям. Также изобретение раскрывает методы конструирования и отбора новых митохондриальноадресованных антиоксидантов с заданными свойствами.
EA201200604A 2009-11-13 2009-11-13 Фармацевтические субстанции на основе митохондриально-адресованных антиоксидантов EA023248B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2009/000621 WO2011059355A1 (ru) 2009-11-13 2009-11-13 Фармацевтические субстанции на основе митохондриально-адресованных антиоксидантов

Publications (2)

Publication Number Publication Date
EA201200604A1 true EA201200604A1 (ru) 2012-09-28
EA023248B1 EA023248B1 (ru) 2016-05-31

Family

ID=43991821

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200604A EA023248B1 (ru) 2009-11-13 2009-11-13 Фармацевтические субстанции на основе митохондриально-адресованных антиоксидантов

Country Status (14)

Country Link
US (1) US9233903B2 (ru)
EP (1) EP2500336A1 (ru)
JP (1) JP2013510849A (ru)
KR (1) KR20120125980A (ru)
CN (1) CN102791670A (ru)
AU (1) AU2009355359B2 (ru)
BR (1) BR112012011197A2 (ru)
CA (2) CA2789846C (ru)
EA (1) EA023248B1 (ru)
IL (1) IL219533A (ru)
MX (1) MX2012005356A (ru)
UA (1) UA107476C2 (ru)
WO (1) WO2011059355A1 (ru)
ZA (1) ZA201203345B (ru)

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JP6448366B2 (ja) * 2011-06-03 2019-01-09 ミトテック ソシエテ アノニム ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用
WO2015063553A2 (en) 2013-04-11 2015-05-07 Mitotech S.A. Mitochondrially-targeted timoquinones and toluquinones
WO2019002936A2 (en) 2017-06-26 2019-01-03 Mitotech S.A. SET OF COMPOUNDS TARGETING MITOCHONDRIA
CN109232219A (zh) * 2018-11-11 2019-01-18 苏州怡彼得生物技术有限公司 一种线粒体靶向抗氧化剂skq1中间体2,3-二甲基-对苯醌的合成方法
CN109232216A (zh) * 2018-11-11 2019-01-18 苏州怡彼得生物技术有限公司 一种线粒体靶向抗氧化剂skq1二季膦盐衍生物的合成方法
CN109900652B (zh) * 2019-04-29 2021-06-04 北京普赞生物技术有限公司 一种食品中双乙酸钠的快速检测方法
KR102527406B1 (ko) 2021-01-15 2023-04-28 아주대학교산학협력단 미토콘드리아 기능 장애 관련 질환 예방 또는 치료용 조성물
KR102410556B1 (ko) 2020-01-16 2022-06-20 아주대학교산학협력단 미토콘드리아 타겟팅용 펩타이드
EP4210695A1 (en) 2020-09-09 2023-07-19 Social Profit Network Methods and compositions for delivery of biotin to mitochondria
WO2023220365A1 (en) * 2022-05-13 2023-11-16 Virginia Tech Intellectual Properties, Inc. Mitochondrial antioxidant treatment for cask-linked neurodevelopmental disorders

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US5538974A (en) 1994-01-27 1996-07-23 Senju Pharamceutical Co., Ltd. Ophthalmic composition for lowering intraocular pressure
US6331532B1 (en) 1998-11-25 2001-12-18 University Of Otago Mitochondrially targeted antioxidants
JP4590523B2 (ja) 1997-11-25 2010-12-01 アンティポディーン ファーマシューティカルズ インコーポレイテッド ミトコンドリアを標的とする抗酸化剤
US20080275005A1 (en) 1998-11-25 2008-11-06 Murphy Michael P Mitochondrially targeted antioxidants
US20070270381A1 (en) 2000-05-25 2007-11-22 Antipodean Pharmaceuticals, Inc. Mitochondrially targeted antioxidants
US20020044913A1 (en) 2000-02-11 2002-04-18 Hamilton Nathan D. Cosmetics to support skin metabolism
ITRM20010755A1 (it) 2001-12-20 2003-06-20 Simonelli Giuseppe Uso del chinone q10 per il trattamento delle malattie oculari.
CA2397684A1 (en) 2002-08-12 2004-02-12 Michael P. Murphy Mitochondrially targeted antioxidants
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WO2006005759A2 (en) 2004-07-13 2006-01-19 Oridis Biomed Forschungs- Und Entwicklungs Gmbh Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers
RU2007111720A (ru) 2004-08-30 2008-10-10 Канека Корпорейшн (Jp) Активаторы митохондрий
RU2318500C2 (ru) 2005-10-18 2008-03-10 Общество С Ограниченной Ответственностью "Митотехнология" Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели
EA200900582A1 (ru) 2006-10-20 2009-08-28 Общество С Ограниченной Ответственностью "Митотехнология" Фармацевтические композиции для профилактики и лечения глазных патологий
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Also Published As

Publication number Publication date
KR20120125980A (ko) 2012-11-19
EA023248B1 (ru) 2016-05-31
EP2500336A1 (en) 2012-09-19
US9233903B2 (en) 2016-01-12
JP2013510849A (ja) 2013-03-28
BR112012011197A2 (pt) 2020-10-20
US20120259110A1 (en) 2012-10-11
AU2009355359A1 (en) 2012-06-07
MX2012005356A (es) 2013-01-29
CA2789846A1 (en) 2011-05-19
CN102791670A (zh) 2012-11-21
AU2009355359B2 (en) 2016-11-10
ZA201203345B (en) 2013-01-30
IL219533A0 (en) 2012-06-28
CA2789846C (en) 2020-02-25
IL219533A (en) 2017-04-30
UA107476C2 (ru) 2015-01-12
CA3068007A1 (en) 2011-05-19
WO2011059355A1 (ru) 2011-05-19
CA3068007C (en) 2022-08-23

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KG MD TJ TM