EA201200322A1 - Метилпирролопиримидинкарбоксамиды - Google Patents

Метилпирролопиримидинкарбоксамиды

Info

Publication number
EA201200322A1
EA201200322A1 EA201200322A EA201200322A EA201200322A1 EA 201200322 A1 EA201200322 A1 EA 201200322A1 EA 201200322 A EA201200322 A EA 201200322A EA 201200322 A EA201200322 A EA 201200322A EA 201200322 A1 EA201200322 A1 EA 201200322A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methylpyrrolopyrimidine
carboxamide
salts
compounds
phosphodiesterase
Prior art date
Application number
EA201200322A
Other languages
English (en)
Other versions
EA021103B1 (ru
Inventor
Йозеф Штадльвизер
Беате Шмидт
Хайко Бернсманн
Торстен Дункерн
Эвальд Бенедиктус
Андреас Паль
Рагна Хуссонг
Олаф Нимц
Маттиас МЮЛЛЕР
Мартин Фиртельхаус
Original Assignee
Никомед Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41698276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201200322(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Никомед Гмбх filed Critical Никомед Гмбх
Publication of EA201200322A1 publication Critical patent/EA201200322A1/ru
Publication of EA021103B1 publication Critical patent/EA021103B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описаны соединения формулы (I)в которой R1, R2, R21, R22, R23, R24, Y и R3 обладают значениями, приведенными в описании, их соли и стереоизомеры соединений и их соли, являющиеся эффективными ингибиторами фосфодиэстеразы типа 5.
EA201200322A 2009-08-26 2010-08-24 Метилпирролопиримидинкарбоксамиды EA021103B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09168685 2009-08-26
PCT/EP2010/062329 WO2011023693A1 (en) 2009-08-26 2010-08-24 Methylpyrrolopyrimidinecarboxamides

Publications (2)

Publication Number Publication Date
EA201200322A1 true EA201200322A1 (ru) 2012-09-28
EA021103B1 EA021103B1 (ru) 2015-04-30

Family

ID=41698276

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200322A EA021103B1 (ru) 2009-08-26 2010-08-24 Метилпирролопиримидинкарбоксамиды

Country Status (26)

Country Link
US (2) US8927557B2 (ru)
EP (1) EP2470536B1 (ru)
JP (1) JP5791606B2 (ru)
KR (1) KR101762884B1 (ru)
CN (1) CN102574861B (ru)
AR (1) AR077898A1 (ru)
AU (1) AU2010288550B2 (ru)
BR (1) BR112012003616A8 (ru)
CA (1) CA2771938A1 (ru)
CL (1) CL2012000271A1 (ru)
CO (1) CO6491110A2 (ru)
EA (1) EA021103B1 (ru)
EC (1) ECSP12011678A (ru)
ES (1) ES2529563T3 (ru)
HK (1) HK1169411A1 (ru)
IL (1) IL218126A (ru)
MX (1) MX2012002432A (ru)
MY (1) MY159031A (ru)
NZ (1) NZ598777A (ru)
PE (1) PE20121133A1 (ru)
SG (1) SG178481A1 (ru)
TN (1) TN2012000034A1 (ru)
TW (1) TWI471327B (ru)
UA (1) UA106628C2 (ru)
WO (1) WO2011023693A1 (ru)
ZA (1) ZA201200616B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
CA2837248A1 (en) 2011-06-17 2012-12-20 Takeda Gmbh Novel phthalazinone -pyrrolopyrimidinecarboxamide derivatives
MX2015010725A (es) * 2013-02-21 2016-05-31 Adverio Pharma Gmbh Formas de metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato.
JP2020097527A (ja) * 2017-03-31 2020-06-25 武田薬品工業株式会社 複素環化合物
CN107286160A (zh) * 2017-06-05 2017-10-24 毛佳婧 一种抗肝炎药物的哌啶并吡啶并吡唑‑锌配合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754260B1 (fr) * 1996-10-04 1998-10-30 Adir Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6187777B1 (en) * 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
DE60105020T2 (de) * 2000-06-07 2005-08-18 Almirall-Prodesfarma S.A. 6-phenylpyrrolopyrimidindion derivate
MXPA03004926A (es) 2001-02-14 2005-02-14 Warner Lambert Co Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas.
CN100374441C (zh) * 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
US20050124623A1 (en) * 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
ATE419848T1 (de) 2004-10-29 2009-01-15 Lilly Co Eli Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1
AU2006221957A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
AU2007293774C1 (en) 2006-09-07 2014-12-18 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
JP4837701B2 (ja) * 2007-04-20 2011-12-14 田辺三菱製薬株式会社 医薬組成物
AR070454A1 (es) 2008-02-27 2010-04-07 Nycomed Gmbh Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden

Also Published As

Publication number Publication date
CN102574861A (zh) 2012-07-11
KR20120107458A (ko) 2012-10-02
EP2470536B1 (en) 2014-11-12
EA021103B1 (ru) 2015-04-30
US9376442B2 (en) 2016-06-28
JP2013503131A (ja) 2013-01-31
ZA201200616B (en) 2012-10-31
BR112012003616A8 (pt) 2018-02-06
NZ598777A (en) 2013-10-25
ES2529563T3 (es) 2015-02-23
IL218126A (en) 2015-08-31
US8927557B2 (en) 2015-01-06
AU2010288550A1 (en) 2012-04-12
CN102574861B (zh) 2015-08-05
TN2012000034A1 (en) 2013-09-19
KR101762884B1 (ko) 2017-07-28
CA2771938A1 (en) 2011-03-03
UA106628C2 (ru) 2014-09-25
US20120149721A1 (en) 2012-06-14
MY159031A (en) 2016-12-15
IL218126A0 (en) 2012-06-28
AU2010288550B2 (en) 2015-01-29
SG178481A1 (en) 2012-03-29
AR077898A1 (es) 2011-09-28
PE20121133A1 (es) 2012-08-30
TWI471327B (zh) 2015-02-01
MX2012002432A (es) 2012-04-11
TW201111384A (en) 2011-04-01
BR112012003616A2 (pt) 2016-02-23
ECSP12011678A (es) 2012-03-30
WO2011023693A1 (en) 2011-03-03
EP2470536A1 (en) 2012-07-04
CL2012000271A1 (es) 2012-08-31
HK1169411A1 (zh) 2013-01-25
CO6491110A2 (es) 2012-07-31
JP5791606B2 (ja) 2015-10-07
US20150073001A1 (en) 2015-03-12

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

TC4A Change in name of a patent proprietor in a eurasian patent
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU