EA201171168A1 - Пиразольное соединение - Google Patents

Пиразольное соединение

Info

Publication number
EA201171168A1
EA201171168A1 EA201171168A EA201171168A EA201171168A1 EA 201171168 A1 EA201171168 A1 EA 201171168A1 EA 201171168 A EA201171168 A EA 201171168A EA 201171168 A EA201171168 A EA 201171168A EA 201171168 A1 EA201171168 A1 EA 201171168A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrogen atom
halogen atom
optionally containing
pyrazolic
connection
Prior art date
Application number
EA201171168A
Other languages
English (en)
Other versions
EA019853B1 (ru
Inventor
Харуюки Нисида
Икуо Фудзимори
Original Assignee
Такеда Фармасьютикал Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA201171168A1 publication Critical patent/EA201171168A1/ru
Publication of EA019853B1 publication Critical patent/EA019853B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Предлагается соединение, обладающее превосходным действием, подавляющим секрецию кислоты, противоязвенной активностью и т.п. Соединение представлено формулойгде Rпредставляет собой заместитель, Rпредставляет собой атом водорода, C-алкильную группу, необязательно содержащую атом галогена, или цианогруппу, Rпредставляет собой атом водорода, атом галогена, цианогруппу, C-алкильную группу, необязательно содержащую атом галогена, или C-алкоксигруппу, необязательно содержащую атом галогена, один из Rи Rпредставляет собой атом водорода, а другой представляет собой заместитель, отличающийся от атома водорода, или его соль.
EA201171168A 2009-03-26 2010-03-25 Производные 1-(пиридин-3-ил)-3-метиламинометил-5-фенилсульфонилпиразола EA019853B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009077078 2009-03-26
PCT/JP2010/055257 WO2010110378A1 (ja) 2009-03-26 2010-03-25 ピラゾール化合物

Publications (2)

Publication Number Publication Date
EA201171168A1 true EA201171168A1 (ru) 2012-05-30
EA019853B1 EA019853B1 (ru) 2014-06-30

Family

ID=42781069

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171168A EA019853B1 (ru) 2009-03-26 2010-03-25 Производные 1-(пиридин-3-ил)-3-метиламинометил-5-фенилсульфонилпиразола

Country Status (25)

Country Link
US (1) US8895588B2 (ru)
EP (1) EP2412713B1 (ru)
JP (1) JP5552481B2 (ru)
KR (1) KR101656906B1 (ru)
CN (1) CN102448953B (ru)
AU (1) AU2010228220B2 (ru)
BR (1) BRPI1009090A2 (ru)
CA (1) CA2756086A1 (ru)
CL (1) CL2011002351A1 (ru)
CO (1) CO6460700A2 (ru)
CR (1) CR20110533A (ru)
DO (1) DOP2011000296A (ru)
EA (1) EA019853B1 (ru)
EC (1) ECSP11011419A (ru)
GE (1) GEP20156222B (ru)
IL (1) IL215235A (ru)
MA (1) MA33214B1 (ru)
MX (1) MX2011009943A (ru)
NZ (1) NZ595890A (ru)
PE (1) PE20120618A1 (ru)
SG (1) SG174476A1 (ru)
TN (1) TN2011000474A1 (ru)
UA (1) UA107457C2 (ru)
WO (1) WO2010110378A1 (ru)
ZA (1) ZA201107435B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201408511QA (en) 2012-06-27 2015-01-29 Takeda Pharmaceutical Liquid preparations of amines and organic acids stabilized by salts
NZ746394A (en) * 2012-09-27 2019-01-25 Aratana Therapeutics Inc Compositions and methods of use of an inappetance-controlling compound
KR20180108916A (ko) 2015-01-28 2018-10-04 아라타나 세라퓨틱스, 인크. 체중-증량 화합물의 장기 사용을 위한 조성물 및 방법
CN105067814A (zh) * 2015-07-24 2015-11-18 中国科学院成都生物研究所 解旋酶水解atp活性测定方法
JP7404561B2 (ja) * 2020-06-17 2023-12-25 イルドン ファーマシューティカル カンパニー リミテッド 新規な酸分泌抑制剤及びその用途

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US3285991A (en) 1963-03-26 1966-11-15 Union Carbide Corp Polyepoxides cured with the reaction product of a dihydroxydiphenylsul-fone, an amine, and an aldehyde
US4847289A (en) 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
ZA927272B (en) 1991-10-29 1994-03-23 Du Pont Herbicidal triazolecarboxamides
DK0786455T3 (da) 1994-09-26 2004-03-29 Shionogi & Co Imidazolderivater
JPH0948778A (ja) 1995-08-04 1997-02-18 Sagami Chem Res Center ２−置換−３−アルコキシ−５−（ピロール−２−イル）フラン誘導体
DE69627377T2 (de) 1995-11-06 2004-02-05 University Of Pittsburgh Inhibitoren der protein-isoprenyl-transferase
CZ225699A3 (cs) 1996-12-23 2000-09-13 Du Pont Pharmaceuticals Company Dusíkaté heteroaromatické sloučeniny jako inhibitory faktoru Xa
AU1918299A (en) 1998-02-23 1999-09-06 Warner-Lambert Company Substituted quinoxaline derivatives as interleukin-8 receptor antagonists
JP4634144B2 (ja) 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
ES2314418T3 (es) 2003-05-02 2009-03-16 Elan Pharmaceuticals, Inc. Derivados de amidas del acido 4-bromo-5-(2-clorobenzoilamino)-1h-pirazol-3-carboxicilico y compuestos relacionados como antagonistas del receptor b1 de bradiquinina para el tratamiento de enfermedades inflamatorias.
JP4716996B2 (ja) 2003-05-26 2011-07-06 武田薬品工業株式会社 スルホピロール
AU2004259012C1 (en) 2003-07-23 2012-08-02 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
JP5173192B2 (ja) 2004-09-30 2013-03-27 武田薬品工業株式会社 プロトンポンプ阻害薬
US7977488B2 (en) * 2005-08-30 2011-07-12 Takeda Pharmaceutical Company Limited 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
CA2647862A1 (en) 2006-03-31 2007-10-11 Takeda Pharmaceutical Company Limited Acid secretion inhibitor
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JP2009077078A (ja) 2007-09-19 2009-04-09 Brother Ind Ltd 位置検出システム
EP3162798B1 (en) 2007-09-28 2021-04-14 Takeda Pharmaceutical Company Limited 5-membered heterocyclic compound
CL2008002834A1 (es) * 2007-09-28 2009-09-11 Takeda Pharmaceuticals Co Compuestos heterociclicos de 5 miembros, composicion farmaceutica, util para el tratamiento de la ulcera peptidica, sindrome de zollinger-ellison, gastritis, esofagitis por reflujo, enfermedad sintomatica por reflujo gastroesofagico, esofago de barrett, cancer gastrico, hiperacidez gastrica o ulcera debido a estres posquirurgico.
PE20091846A1 (es) 2008-05-19 2009-12-16 Plexxikon Inc DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
CN102099339A (zh) 2008-07-18 2011-06-15 武田药品工业株式会社 苯并氮杂衍生物及其作为组胺h3拮抗剂的用途

Also Published As

Publication number Publication date
GEP20156222B (en) 2015-01-26
SG174476A1 (en) 2011-10-28
PE20120618A1 (es) 2012-06-05
CN102448953B (zh) 2014-05-07
KR20110130483A (ko) 2011-12-05
EP2412713A1 (en) 2012-02-01
US20120095057A1 (en) 2012-04-19
UA107457C2 (ru) 2015-01-12
EP2412713A4 (en) 2014-04-02
KR101656906B1 (ko) 2016-09-12
CO6460700A2 (es) 2012-06-15
WO2010110378A1 (ja) 2010-09-30
ECSP11011419A (es) 2011-11-30
JP5552481B2 (ja) 2014-07-16
AU2010228220A2 (en) 2011-11-24
EA019853B1 (ru) 2014-06-30
BRPI1009090A2 (pt) 2016-03-01
CN102448953A (zh) 2012-05-09
CR20110533A (es) 2012-02-13
CL2011002351A1 (es) 2012-07-13
CA2756086A1 (en) 2010-09-30
IL215235A0 (en) 2011-12-29
NZ595890A (en) 2013-09-27
DOP2011000296A (es) 2011-10-15
AU2010228220A1 (en) 2011-11-17
IL215235A (en) 2014-07-31
AU2010228220B2 (en) 2015-05-21
EP2412713B1 (en) 2016-11-30
ZA201107435B (en) 2012-08-29
JPWO2010110378A1 (ja) 2012-10-04
MA33214B1 (fr) 2012-04-02
US8895588B2 (en) 2014-11-25
MX2011009943A (es) 2011-10-06
TN2011000474A1 (en) 2013-03-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU