EA201071421A1 - Анти-flt3 антитела - Google Patents
Анти-flt3 антителаInfo
- Publication number
- EA201071421A1 EA201071421A1 EA201071421A EA201071421A EA201071421A1 EA 201071421 A1 EA201071421 A1 EA 201071421A1 EA 201071421 A EA201071421 A EA 201071421A EA 201071421 A EA201071421 A EA 201071421A EA 201071421 A1 EA201071421 A1 EA 201071421A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- present
- flt3 antibodies
- flt3
- administering
- antibodies
- Prior art date
Links
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 abstract 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 102000049850 human FLT3 Human genes 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13039508P | 2008-05-30 | 2008-05-30 | |
| US13053908P | 2008-05-30 | 2008-05-30 | |
| US13039408P | 2008-05-30 | 2008-05-30 | |
| PCT/US2009/045365 WO2009155015A1 (en) | 2008-05-30 | 2009-05-28 | Anti-flt3 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201071421A1 true EA201071421A1 (ru) | 2011-08-30 |
Family
ID=41092183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201071421A EA201071421A1 (ru) | 2008-05-30 | 2009-05-28 | Анти-flt3 антитела |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20110091470A1 (enExample) |
| EP (1) | EP2300500A1 (enExample) |
| JP (1) | JP2011521647A (enExample) |
| KR (1) | KR20110004455A (enExample) |
| CN (1) | CN102046659A (enExample) |
| AR (1) | AR071891A1 (enExample) |
| AU (1) | AU2009260517B2 (enExample) |
| BR (1) | BRPI0912173A2 (enExample) |
| CA (1) | CA2726522A1 (enExample) |
| CL (1) | CL2009001277A1 (enExample) |
| EA (1) | EA201071421A1 (enExample) |
| IL (1) | IL209142A0 (enExample) |
| MX (1) | MX2010013144A (enExample) |
| NZ (1) | NZ588791A (enExample) |
| PE (1) | PE20091963A1 (enExample) |
| TW (1) | TWI374032B (enExample) |
| WO (1) | WO2009155015A1 (enExample) |
| ZA (1) | ZA201008024B (enExample) |
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| WO2011113041A2 (en) * | 2010-03-12 | 2011-09-15 | The Johns Hopkins University | Neutralization of flt3 ligand as a leukemia therapy |
| BR112014006822B1 (pt) * | 2011-09-22 | 2021-05-18 | Amgen Inc. | Proteína de ligação ao antígeno cd27l, composição compreendendo uma proteína de ligação ao antígeno cd27l, ácido nucleico isolado, vetor de expressão, célula hospedeira recombinante procariótica, método de preparação de um conjugado de droga e anticorpo cd27l e uso de uma proteína de ligação ao antígeno cd27l |
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| US12128069B2 (en) | 2015-04-23 | 2024-10-29 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
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| AU2002314495A1 (en) | 2001-06-20 | 2003-01-02 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| WO2005094823A1 (ja) | 2004-03-30 | 2005-10-13 | Kyowa Hakko Kogyo Co., Ltd. | Ｆｌｔ－３阻害剤 |
| US8227455B2 (en) | 2005-04-18 | 2012-07-24 | Rigel Pharmaceuticals, Inc. | Methods of treating cell proliferative disorders |
| US9273134B2 (en) | 2007-06-05 | 2016-03-01 | Yale University | Inhibitors of receptor tyrosine kinases and methods of use thereof |
| AR071891A1 (es) * | 2008-05-30 | 2010-07-21 | Imclone Llc | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
-
2009
- 2009-05-22 AR ARP090101855A patent/AR071891A1/es not_active Application Discontinuation
- 2009-05-25 CL CL2009001277A patent/CL2009001277A1/es unknown
- 2009-05-25 PE PE2009000733A patent/PE20091963A1/es not_active Application Discontinuation
- 2009-05-28 CN CN2009801189357A patent/CN102046659A/zh active Pending
- 2009-05-28 MX MX2010013144A patent/MX2010013144A/es active IP Right Grant
- 2009-05-28 US US12/994,956 patent/US20110091470A1/en not_active Abandoned
- 2009-05-28 WO PCT/US2009/045365 patent/WO2009155015A1/en not_active Ceased
- 2009-05-28 CA CA2726522A patent/CA2726522A1/en not_active Abandoned
- 2009-05-28 NZ NZ588791A patent/NZ588791A/en not_active IP Right Cessation
- 2009-05-28 KR KR1020107026790A patent/KR20110004455A/ko not_active Ceased
- 2009-05-28 US US12/473,295 patent/US20090297529A1/en not_active Abandoned
- 2009-05-28 JP JP2011511791A patent/JP2011521647A/ja not_active Withdrawn
- 2009-05-28 AU AU2009260517A patent/AU2009260517B2/en not_active Expired - Fee Related
- 2009-05-28 EA EA201071421A patent/EA201071421A1/ru unknown
- 2009-05-28 BR BRPI0912173A patent/BRPI0912173A2/pt not_active IP Right Cessation
- 2009-05-28 EP EP09767327A patent/EP2300500A1/en not_active Ceased
- 2009-06-01 TW TW098118092A patent/TWI374032B/zh not_active IP Right Cessation
-
2010
- 2010-09-27 US US12/890,793 patent/US8071099B2/en not_active Expired - Fee Related
- 2010-11-04 IL IL209142A patent/IL209142A0/en unknown
- 2010-11-09 ZA ZA2010/08024A patent/ZA201008024B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2300500A1 (en) | 2011-03-30 |
| TWI374032B (en) | 2012-10-11 |
| CL2009001277A1 (es) | 2010-10-08 |
| IL209142A0 (en) | 2011-01-31 |
| KR20110004455A (ko) | 2011-01-13 |
| WO2009155015A1 (en) | 2009-12-23 |
| US20110008355A1 (en) | 2011-01-13 |
| BRPI0912173A2 (pt) | 2016-07-26 |
| JP2011521647A (ja) | 2011-07-28 |
| TW201010722A (en) | 2010-03-16 |
| AU2009260517A1 (en) | 2009-12-23 |
| PE20091963A1 (es) | 2010-01-15 |
| ZA201008024B (en) | 2012-04-25 |
| US8071099B2 (en) | 2011-12-06 |
| US20110091470A1 (en) | 2011-04-21 |
| AU2009260517B2 (en) | 2012-12-06 |
| MX2010013144A (es) | 2010-12-21 |
| CN102046659A (zh) | 2011-05-04 |
| AR071891A1 (es) | 2010-07-21 |
| CA2726522A1 (en) | 2009-12-23 |
| NZ588791A (en) | 2012-05-25 |
| US20090297529A1 (en) | 2009-12-03 |
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