EA201000971A1 - Модуляторы каннабиноидного рецептора - Google Patents
Модуляторы каннабиноидного рецептораInfo
- Publication number
- EA201000971A1 EA201000971A1 EA201000971A EA201000971A EA201000971A1 EA 201000971 A1 EA201000971 A1 EA 201000971A1 EA 201000971 A EA201000971 A EA 201000971A EA 201000971 A EA201000971 A EA 201000971A EA 201000971 A1 EA201000971 A1 EA 201000971A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- hydrogen
- formula
- radical
- ring
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Соединения формулы (I) являются модуляторами каннабиноидного рецептора СВ1, применяемого наряду с прочим для лечения ожирениягде Х означает связь или двухвалентный радикал, выбранный из -C(R)(R)-*, -C(R)(R)-O-*, -C(R)(R)CH-*, -C(R)(R)CH-O-*, -CHC(R)(R))-*, -CHC(R)(R)-O-* и -CH-O-C(R)(R)-*, где связь, обозначенная звёздочкой, присоединена к пиразольному кольцу; Z обозначает карбоксильный изостерный радикал, выбранный из определённой группы; Rобозначает водород, (C-С)алкил или (C-С)фторалкил; Rобозначает радикал формулы -(Alk)-(Q)-(L)-Q, где р, r, s, Alk, L, Qи Qимеют указанные значения; или Rи R, взятые вместе с атомом азота, к которому они присоединены, образуют циклическое аминное кольцо, содержащее в кольце 4-7 атомов, которое может быть замещено радикалом формулы -(L)-Q, где s, L и Qопределены выше, или заместителем, выбранным из гидрокси, метокси, -NH- или моно- или ди-(С-С)алкиламино;R, R, Rи Rкаждый независимо выбраны из водорода, -F, -Cl, -Br -CN, (C-С)алкила, (C-С) фторалкила, циклопропила и -OR; Rобозначает водород, (C-С)алкил, гидроксил или NHи Rобозначает водород или (C-С)алкил; или Rи R, взятые вместе с атомом углерода, к которому они присоединены, образуют (С-С)циклоалкильное кольцо.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0724096A GB0724096D0 (en) | 2007-12-10 | 2007-12-10 | Cannabinoid receptor modulators |
GB0813350A GB0813350D0 (en) | 2008-07-21 | 2008-07-21 | Cannabinoid receptor modulators |
PCT/GB2008/004051 WO2009074782A1 (en) | 2007-12-10 | 2008-12-08 | Cannabinoid receptor modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201000971A1 true EA201000971A1 (ru) | 2011-02-28 |
EA018900B1 EA018900B1 (ru) | 2013-11-29 |
Family
ID=40344724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000971A EA018900B1 (ru) | 2007-12-10 | 2008-12-08 | Соединения, модулирующие активность каннабиноидного рецептора св1, композиции на их основе и их применение |
Country Status (14)
Country | Link |
---|---|
US (1) | US8173680B2 (ru) |
EP (1) | EP2231615A1 (ru) |
JP (1) | JP2011506410A (ru) |
KR (1) | KR20100091255A (ru) |
CN (1) | CN101896465A (ru) |
AU (1) | AU2008334489A1 (ru) |
BR (1) | BRPI0822061A2 (ru) |
CA (1) | CA2708706A1 (ru) |
EA (1) | EA018900B1 (ru) |
IL (1) | IL205980A0 (ru) |
MX (1) | MX2010006109A (ru) |
NZ (1) | NZ585704A (ru) |
WO (1) | WO2009074782A1 (ru) |
ZA (1) | ZA201004828B (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR079967A1 (es) * | 2010-01-26 | 2012-02-29 | Sanofi Aventis | Derivados de acido 3-heteroaroilamino-propionico sustituidos con oxigeno y su uso como productos farmaceuticos |
BR112013013490B1 (pt) * | 2011-09-30 | 2019-10-22 | National Health Research Institutes | compostos e composição farmacêutica |
US9505728B2 (en) | 2012-03-09 | 2016-11-29 | Inception 2, Inc. | Triazolone compounds and uses thereof |
EP2919779B1 (en) | 2012-11-13 | 2021-01-06 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Cannabinoid receptor mediating compounds |
US11155521B2 (en) * | 2012-11-13 | 2021-10-26 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Cannabinoid receptor mediating compounds |
AU2013363398B2 (en) | 2012-12-20 | 2017-06-01 | Tempest Therapeutics, Inc. | Triazolone compounds and uses thereof |
EA201690230A1 (ru) | 2013-09-06 | 2016-07-29 | Инсепшн 2, Инк. | Соединения триазолона и их применения |
US10329259B2 (en) | 2014-05-09 | 2019-06-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Pyrazole derivatives and their use as cannabinoid receptor mediators |
US11091447B2 (en) | 2020-01-03 | 2021-08-17 | Berg Llc | UBE2K modulators and methods for their use |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2741621B1 (fr) * | 1995-11-23 | 1998-02-13 | Sanofi Sa | Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant |
FR2856683A1 (fr) * | 2003-06-25 | 2004-12-31 | Sanofi Synthelabo | Derives de 4-cyanopyrazole-3-carboxamide, leur preparation et leur application en therapeutique |
RU2007119315A (ru) * | 2004-10-25 | 2008-11-27 | Зольвай Фармасьютиклз Гмбх (De) | Фармацевтические композиции, содержащие антагонисты каннабиноидного рецептора св1 и открыватели калиевых каналов, предназначенные для лечения сахарного диабета типа i, ожирения и связанных с ними состояний |
US20080146614A1 (en) * | 2004-12-23 | 2008-06-19 | Leifeng Cheng | Therapeutic Agents |
EP1928859A1 (en) * | 2005-06-17 | 2008-06-11 | Carex SA | Pyrazole derivates as cannabinoid receptor modulators |
JP5069894B2 (ja) * | 2005-10-21 | 2012-11-07 | 田辺三菱製薬株式会社 | ピラゾール化合物 |
CN101437398A (zh) * | 2006-03-10 | 2009-05-20 | 詹里恩探索公司 | 用于治疗肥胖症的大麻素受体拮抗剂/反向激动剂 |
WO2007138050A1 (en) * | 2006-05-31 | 2007-12-06 | Solvay Pharmaceuticals B.V. | Sulphur containing pyrazole derivatives as selective cannabinoid cb1 receptor antagonists |
GB0622569D0 (en) * | 2006-11-11 | 2006-12-20 | 7Tm Pharma As | Cannabinoid receptor modulators |
CA2673359A1 (en) * | 2006-12-18 | 2008-06-26 | 7Tm Pharma A/S | Cb1 receptor modulators |
-
2008
- 2008-12-08 KR KR1020107015316A patent/KR20100091255A/ko not_active Application Discontinuation
- 2008-12-08 US US12/745,708 patent/US8173680B2/en not_active Expired - Fee Related
- 2008-12-08 CN CN200880120649XA patent/CN101896465A/zh active Pending
- 2008-12-08 EP EP08860004A patent/EP2231615A1/en not_active Withdrawn
- 2008-12-08 CA CA2708706A patent/CA2708706A1/en not_active Abandoned
- 2008-12-08 JP JP2010537504A patent/JP2011506410A/ja active Pending
- 2008-12-08 WO PCT/GB2008/004051 patent/WO2009074782A1/en active Application Filing
- 2008-12-08 MX MX2010006109A patent/MX2010006109A/es not_active Application Discontinuation
- 2008-12-08 AU AU2008334489A patent/AU2008334489A1/en not_active Abandoned
- 2008-12-08 NZ NZ585704A patent/NZ585704A/xx not_active IP Right Cessation
- 2008-12-08 EA EA201000971A patent/EA018900B1/ru not_active IP Right Cessation
- 2008-12-08 BR BRPI0822061-1A patent/BRPI0822061A2/pt not_active IP Right Cessation
-
2010
- 2010-05-26 IL IL205980A patent/IL205980A0/en unknown
- 2010-07-08 ZA ZA2010/04828A patent/ZA201004828B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA018900B1 (ru) | 2013-11-29 |
US8173680B2 (en) | 2012-05-08 |
US20100292273A1 (en) | 2010-11-18 |
NZ585704A (en) | 2012-08-31 |
MX2010006109A (es) | 2010-09-10 |
CN101896465A (zh) | 2010-11-24 |
IL205980A0 (en) | 2010-11-30 |
JP2011506410A (ja) | 2011-03-03 |
WO2009074782A1 (en) | 2009-06-18 |
AU2008334489A1 (en) | 2009-06-18 |
EP2231615A1 (en) | 2010-09-29 |
KR20100091255A (ko) | 2010-08-18 |
BRPI0822061A2 (pt) | 2015-06-23 |
ZA201004828B (en) | 2011-03-30 |
CA2708706A1 (en) | 2009-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |