EA200970817A1 - Лекарственная форма, содержащая 1{6-[(3-циклобутил-2,3,4,5-тетрагидро-1н-3-бензазепин-7-ил)окси]-3-пиридинил}-2-пирролидинон или его соль и стабилизатор, который уменьшает его деградацию - Google Patents
Лекарственная форма, содержащая 1{6-[(3-циклобутил-2,3,4,5-тетрагидро-1н-3-бензазепин-7-ил)окси]-3-пиридинил}-2-пирролидинон или его соль и стабилизатор, который уменьшает его деградациюInfo
- Publication number
- EA200970817A1 EA200970817A1 EA200970817A EA200970817A EA200970817A1 EA 200970817 A1 EA200970817 A1 EA 200970817A1 EA 200970817 A EA200970817 A EA 200970817A EA 200970817 A EA200970817 A EA 200970817A EA 200970817 A1 EA200970817 A1 EA 200970817A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dosage form
- benzazepin
- pyrrolidinone
- pyridinyl
- cyclobutyl
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title abstract 4
- YFRBKEVUUCQYOW-UHFFFAOYSA-N 1-[6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]pyridin-3-yl]pyrrolidin-2-one Chemical compound O=C1CCCN1C(C=N1)=CC=C1OC1=CC=C(CCN(CC2)C3CCC3)C2=C1 YFRBKEVUUCQYOW-UHFFFAOYSA-N 0.000 title 1
- 230000015556 catabolic process Effects 0.000 title 1
- 238000006731 degradation reaction Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000003381 stabilizer Substances 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A61K9/2806—Coating materials
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
Abstract
Настоящее изобретение относится к новой лекарственной форме, к способу получения лекарственной формы и к применению лекарственной формы в лечении неврологических и психиатрических расстройств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89226707P | 2007-03-01 | 2007-03-01 | |
PCT/EP2008/052430 WO2008104590A2 (en) | 2007-03-01 | 2008-02-28 | Novel dosage form |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970817A1 true EA200970817A1 (ru) | 2010-06-30 |
EA019865B1 EA019865B1 (ru) | 2014-06-30 |
Family
ID=39248198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970817A EA019865B1 (ru) | 2007-03-01 | 2008-02-28 | Лекарственная форма, содержащая 1{6-[(3-циклобутил-2,3,4,5-тетрагидро-1н-3-бензазепин-7-ил)окси]-3-пиридинил}-2-пирролидинон или его соль и стабилизатор, который уменьшает его деградацию |
Country Status (30)
Country | Link |
---|---|
US (1) | US20110014283A1 (ru) |
EP (1) | EP2131818B1 (ru) |
JP (2) | JP5743177B2 (ru) |
KR (1) | KR101504371B1 (ru) |
CN (1) | CN101674806B (ru) |
AR (1) | AR065529A1 (ru) |
AU (1) | AU2008220795B2 (ru) |
BR (1) | BRPI0807882A2 (ru) |
CA (1) | CA2679529A1 (ru) |
CL (1) | CL2008000596A1 (ru) |
CO (1) | CO6220900A2 (ru) |
CR (1) | CR11013A (ru) |
DK (1) | DK2131818T3 (ru) |
DO (1) | DOP2009000207A (ru) |
EA (1) | EA019865B1 (ru) |
ES (1) | ES2463468T3 (ru) |
HK (1) | HK1137363A1 (ru) |
HR (1) | HRP20140390T1 (ru) |
IL (1) | IL200619A (ru) |
MA (1) | MA31198B1 (ru) |
MX (1) | MX2009009362A (ru) |
NZ (1) | NZ579374A (ru) |
PE (1) | PE20090114A1 (ru) |
PL (1) | PL2131818T3 (ru) |
PT (1) | PT2131818E (ru) |
SI (1) | SI2131818T1 (ru) |
TW (1) | TWI424856B (ru) |
UA (1) | UA102515C2 (ru) |
WO (1) | WO2008104590A2 (ru) |
ZA (1) | ZA200905866B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200808773A (en) | 2006-06-23 | 2008-02-16 | Abbott Lab | Cyclopropyl amine derivatives |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
EP2328587A1 (en) * | 2008-08-29 | 2011-06-08 | Glaxo Group Limited | Dosage form comprising 1-isopropyl-4-{ [4-(tetrahydro-2h-pyran- 4-yloxy)phenyl]carbonyl}hexahydro-1h-1,4-diazepine or a salt thereof |
US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
WO2011051423A1 (en) | 2009-11-02 | 2011-05-05 | Glaxo Group Limited | Treatment or prophylaxis of dementia, neurodegenerative disorders, schizophrenia, adhd, somnolence or epilepsy |
US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
EP3623371A1 (en) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
RU2017145964A (ru) | 2015-06-10 | 2019-07-10 | Аксовант Сайенсиз Гмбх | Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов |
WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69431662T2 (de) * | 1993-09-03 | 2003-09-18 | Smithkline Beecham Corp | Stabilisierte tablettenformulierung |
BR9915835A (pt) * | 1998-12-01 | 2001-08-21 | Novo Nordisk As | Composição farmacêutica, e, processo para a preparação de uma composição |
US20040037869A1 (en) * | 2002-08-16 | 2004-02-26 | Douglas Cleverly | Non-animal product containing veterinary formulations |
CA2509413C (en) * | 2002-12-20 | 2012-05-01 | Glaxo Group Limited | Benzazepine derivatives for the treatment of neurological disorders |
CN1805938B (zh) * | 2003-06-17 | 2010-06-16 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
WO2005000354A1 (ja) * | 2003-06-30 | 2005-01-06 | Takeda Pharmaceutical Company Limited | 排尿障害予防・治療剤 |
WO2005042491A1 (en) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
US20060002986A1 (en) * | 2004-06-09 | 2006-01-05 | Smithkline Beecham Corporation | Pharmaceutical product |
JP2008502644A (ja) * | 2004-06-18 | 2008-01-31 | グラクソ グループ リミテッド | ヒスタミンh3アンタゴニストとしての3−シクロアルキルベンズアゼピン |
JP2006022039A (ja) * | 2004-07-08 | 2006-01-26 | Towa Yakuhin Kk | 高い安定性を有するシンバスタチン固形製剤 |
GB0418267D0 (en) * | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
-
2008
- 2008-02-27 CL CL200800596A patent/CL2008000596A1/es unknown
- 2008-02-28 AU AU2008220795A patent/AU2008220795B2/en not_active Ceased
- 2008-02-28 MX MX2009009362A patent/MX2009009362A/es active IP Right Grant
- 2008-02-28 SI SI200831205T patent/SI2131818T1/sl unknown
- 2008-02-28 CA CA002679529A patent/CA2679529A1/en not_active Abandoned
- 2008-02-28 EA EA200970817A patent/EA019865B1/ru not_active IP Right Cessation
- 2008-02-28 PL PL08717221T patent/PL2131818T3/pl unknown
- 2008-02-28 US US12/528,492 patent/US20110014283A1/en not_active Abandoned
- 2008-02-28 UA UAA200909976A patent/UA102515C2/ru unknown
- 2008-02-28 KR KR1020097020444A patent/KR101504371B1/ko not_active IP Right Cessation
- 2008-02-28 BR BRPI0807882-3A2A patent/BRPI0807882A2/pt not_active IP Right Cessation
- 2008-02-28 PT PT87172219T patent/PT2131818E/pt unknown
- 2008-02-28 EP EP08717221.9A patent/EP2131818B1/en not_active Not-in-force
- 2008-02-28 DK DK08717221.9T patent/DK2131818T3/da active
- 2008-02-28 ES ES08717221.9T patent/ES2463468T3/es active Active
- 2008-02-28 AR ARP080100842A patent/AR065529A1/es unknown
- 2008-02-28 NZ NZ579374A patent/NZ579374A/en not_active IP Right Cessation
- 2008-02-28 WO PCT/EP2008/052430 patent/WO2008104590A2/en active Application Filing
- 2008-02-28 JP JP2009551216A patent/JP5743177B2/ja not_active Expired - Fee Related
- 2008-02-28 PE PE2008000398A patent/PE20090114A1/es not_active Application Discontinuation
- 2008-02-28 CN CN2008800144640A patent/CN101674806B/zh not_active Expired - Fee Related
- 2008-02-29 TW TW097106936A patent/TWI424856B/zh not_active IP Right Cessation
-
2009
- 2009-08-24 ZA ZA200905866A patent/ZA200905866B/xx unknown
- 2009-08-27 IL IL200619A patent/IL200619A/en not_active IP Right Cessation
- 2009-08-28 DO DO2009000207A patent/DOP2009000207A/es unknown
- 2009-08-31 MA MA32184A patent/MA31198B1/fr unknown
- 2009-09-02 CR CR11013A patent/CR11013A/es unknown
- 2009-09-10 CO CO09097361A patent/CO6220900A2/es not_active Application Discontinuation
-
2010
- 2010-05-20 HK HK10104983.9A patent/HK1137363A1/xx not_active IP Right Cessation
-
2014
- 2014-04-29 HR HRP20140390AT patent/HRP20140390T1/hr unknown
- 2014-09-19 JP JP2014191832A patent/JP2015038098A/ja not_active Withdrawn
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