EA200900681A1 - Композиция для лечения респираторных синцитиальных вирусов - Google Patents

Композиция для лечения респираторных синцитиальных вирусов

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Publication number
EA200900681A1
EA200900681A1 EA200900681A EA200900681A EA200900681A1 EA 200900681 A1 EA200900681 A1 EA 200900681A1 EA 200900681 A EA200900681 A EA 200900681A EA 200900681 A EA200900681 A EA 200900681A EA 200900681 A1 EA200900681 A1 EA 200900681A1
Authority
EA
Eurasian Patent Office
Prior art keywords
viruses
treatment
composition
gene
respiratory synctial
Prior art date
Application number
EA200900681A
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English (en)
Other versions
EA017847B1 (ru
Inventor
Рэйчел Мейерз
Original Assignee
Элнилэм Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Publication of EA200900681A1 publication Critical patent/EA200900681A1/ru
Publication of EA017847B1 publication Critical patent/EA017847B1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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Abstract

Настоящее изобретение относится к специфическим композициям, которые являются эффективными для снижения уровней мРНК RSV, уровней белка RSV и титров вируса у пациента, например, млекопитающего, такого как человек.
EA200900681A 2005-01-07 2006-01-06 Композиция для лечения респираторных синцитиальных вирусов EA017847B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64236405P 2005-01-07 2005-01-07
US65982805P 2005-03-09 2005-03-09

Publications (2)

Publication Number Publication Date
EA200900681A1 true EA200900681A1 (ru) 2009-12-30
EA017847B1 EA017847B1 (ru) 2013-03-29

Family

ID=36648197

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200701450A EA012573B1 (ru) 2005-01-07 2006-01-06 РНКi МОДУЛЯЦИЯ RSV И ЕЁ ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ
EA201201356A EA201201356A1 (ru) 2005-01-07 2006-01-06 Композиция для лечения респираторных синцитиальных вирусов
EA200900681A EA017847B1 (ru) 2005-01-07 2006-01-06 Композиция для лечения респираторных синцитиальных вирусов

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EA200701450A EA012573B1 (ru) 2005-01-07 2006-01-06 РНКi МОДУЛЯЦИЯ RSV И ЕЁ ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ
EA201201356A EA201201356A1 (ru) 2005-01-07 2006-01-06 Композиция для лечения респираторных синцитиальных вирусов

Country Status (14)

Country Link
US (8) US7507809B2 (ru)
EP (4) EP1833490A4 (ru)
JP (3) JP5081630B2 (ru)
KR (1) KR101169668B1 (ru)
CN (2) CN102600480B (ru)
AT (1) ATE551421T1 (ru)
AU (2) AU2006203934B2 (ru)
CA (1) CA2594334A1 (ru)
DK (1) DK2230304T3 (ru)
EA (3) EA012573B1 (ru)
ES (1) ES2385811T3 (ru)
IL (2) IL184162A (ru)
NZ (1) NZ556097A (ru)
WO (1) WO2006074346A2 (ru)

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IL184162A (en) 2013-07-31
EP2230304A1 (en) 2010-09-22
EA200701450A1 (ru) 2008-02-28
KR101169668B1 (ko) 2012-08-07
JP2012006980A (ja) 2012-01-12
US20090240043A1 (en) 2009-09-24
JP5081630B2 (ja) 2012-11-28
US8263572B2 (en) 2012-09-11
EA017847B1 (ru) 2013-03-29
KR20070110019A (ko) 2007-11-15
AU2010224450B2 (en) 2014-04-10
US20060166921A1 (en) 2006-07-27
US20130030037A1 (en) 2013-01-31
US20060258608A1 (en) 2006-11-16
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CA2594334A1 (en) 2006-07-13
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IL217332A0 (en) 2012-02-29
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