EA200801945A1 - Пирролотриазинанилиновые пролекарственные соединения, полезные в качестве ингибиторов киназы - Google Patents

Пирролотриазинанилиновые пролекарственные соединения, полезные в качестве ингибиторов киназы

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Publication number
EA200801945A1
EA200801945A1 EA200801945A EA200801945A EA200801945A1 EA 200801945 A1 EA200801945 A1 EA 200801945A1 EA 200801945 A EA200801945 A EA 200801945A EA 200801945 A EA200801945 A EA 200801945A EA 200801945 A1 EA200801945 A1 EA 200801945A1
Authority
EA
Eurasian Patent Office
Prior art keywords
useful
kinase inhibitors
pyrrolotriazinanilinum
medical
medicinal compounds
Prior art date
Application number
EA200801945A
Other languages
English (en)
Russian (ru)
Inventor
Чунджиан Лиу
Катерина Лефтерис
Вивекананда М. Врудхула
Джеймс Лин
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA200801945A1 publication Critical patent/EA200801945A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurology (AREA)
  • Communicable Diseases (AREA)
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  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
EA200801945A 2006-03-07 2007-03-05 Пирролотриазинанилиновые пролекарственные соединения, полезные в качестве ингибиторов киназы EA200801945A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77985106P 2006-03-07 2006-03-07
PCT/US2007/063250 WO2007103839A2 (en) 2006-03-07 2007-03-05 Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
EA200801945A1 true EA200801945A1 (ru) 2009-02-27

Family

ID=38475749

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801945A EA200801945A1 (ru) 2006-03-07 2007-03-05 Пирролотриазинанилиновые пролекарственные соединения, полезные в качестве ингибиторов киназы

Country Status (17)

Country Link
US (2) US7572795B2 (OSRAM)
EP (1) EP2001886A2 (OSRAM)
JP (1) JP2009535295A (OSRAM)
KR (1) KR20080107408A (OSRAM)
CN (1) CN101395158A (OSRAM)
AR (1) AR059778A1 (OSRAM)
AU (1) AU2007223342A1 (OSRAM)
BR (1) BRPI0708644A2 (OSRAM)
CA (1) CA2645031A1 (OSRAM)
EA (1) EA200801945A1 (OSRAM)
IL (1) IL193653A0 (OSRAM)
MX (1) MX2008011136A (OSRAM)
NO (1) NO20083717L (OSRAM)
PE (1) PE20080139A1 (OSRAM)
TW (1) TW200804390A (OSRAM)
WO (1) WO2007103839A2 (OSRAM)
ZA (1) ZA200807459B (OSRAM)

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WO2009158450A1 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, preparation and use thereof
WO2009158446A2 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, method of preparation and use thereof
DK2334378T3 (da) 2008-08-19 2014-07-07 Xenoport Inc Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse
EP2376491B1 (en) 2008-12-19 2015-03-04 Cephalon, Inc. Pyrrolotriazines as alk and jak2 inhibitors
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JP5752232B2 (ja) 2010-03-31 2015-07-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ プロテインキナーゼ阻害剤としての置換ピロロトリアジン化合物
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CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
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