EA200602273A1 - Замещённые гетероарильные и фенилсульфамоильные соединения - Google Patents
Замещённые гетероарильные и фенилсульфамоильные соединенияInfo
- Publication number
- EA200602273A1 EA200602273A1 EA200602273A EA200602273A EA200602273A1 EA 200602273 A1 EA200602273 A1 EA 200602273A1 EA 200602273 A EA200602273 A EA 200602273A EA 200602273 A EA200602273 A EA 200602273A EA 200602273 A1 EA200602273 A1 EA 200602273A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- substituted heteroaryl
- cholesterol
- diseases
- ppar
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract
Настоящее изобретение относится к замещенным гетероарильным и фенилсульфамоильным соединениям, фармацевтическим композициям, содержащим такие соединения, и к применению таких соединений в качестве агонистов рецептора, активируемого пролифератором пероксисом (PPAR). Предлагаются активаторы PPAR-альфа, фармацевтические композиции, содержащие такие соединения, и применение таких соединений для повышения уровней некоторых липидов в плазме, включая холестерин липопротеидов высокой плотности, и для снижения уровней некоторых других липидов в плазме, таких как холестерин ЛНП и триглицериды, и соответственно для лечения заболеваний, которые обостряются низкими уровнями холестерина ЛВП и/или высокими уровнями холестерина ЛНП и триглицеридов, таких как атеросклероз и сердечно-сосудистые заболевания, у млекопитающих, включая человека. Соединения также применимы для лечения отрицательного баланса энергии (NEB) и связанных заболеваний у жвачных животных.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US58372104P | 2004-06-29 | 2004-06-29 | |
PCT/IB2005/002007 WO2006003495A1 (en) | 2004-06-29 | 2005-06-17 | Substituted heteroaryl- and phenylsulfamoyl compounds |
Publications (1)
Publication Number | Publication Date |
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EA200602273A1 true EA200602273A1 (ru) | 2007-06-29 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA200602273A EA200602273A1 (ru) | 2004-06-29 | 2005-06-17 | Замещённые гетероарильные и фенилсульфамоильные соединения |
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US (3) | US20050288340A1 (ru) |
EP (1) | EP1765796A1 (ru) |
JP (1) | JP2008505170A (ru) |
KR (1) | KR20070030287A (ru) |
CN (1) | CN101287718A (ru) |
AP (1) | AP2007003889A0 (ru) |
AR (1) | AR054665A1 (ru) |
AU (1) | AU2005258906A1 (ru) |
BR (1) | BRPI0512624A (ru) |
CA (1) | CA2573193A1 (ru) |
CR (1) | CR8881A (ru) |
EA (1) | EA200602273A1 (ru) |
EC (1) | ECSP067125A (ru) |
GT (1) | GT200500173A (ru) |
IL (1) | IL180426A0 (ru) |
MA (1) | MA28703B1 (ru) |
MX (1) | MX2007000289A (ru) |
NL (1) | NL1029360C2 (ru) |
NO (1) | NO20070511L (ru) |
PA (1) | PA8638001A1 (ru) |
PE (1) | PE20060415A1 (ru) |
SV (1) | SV2006002158A (ru) |
TN (1) | TNSN06447A1 (ru) |
TW (1) | TW200611690A (ru) |
UY (1) | UY28988A1 (ru) |
WO (1) | WO2006003495A1 (ru) |
ZA (1) | ZA200610783B (ru) |
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CA2883306C (en) | 2012-08-27 | 2021-10-19 | University Of Tennessee Research Foundation | Lpa2 receptor-specific benzoic acid derivatives |
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BR112015023294A2 (pt) * | 2013-03-15 | 2017-07-18 | Shifa Biomedical Corp | método para tratamento ou prevenção de uma doença |
AU2014237198A1 (en) | 2013-03-15 | 2015-11-05 | Shifa Biomedical Corporation | Anti-PCSK9 compounds and methods for the treatment and/or prevention of cardiovascular diseases |
AU2015237788B2 (en) * | 2014-03-27 | 2021-03-11 | Piramal Enterprises Limited | ROR-gamma modulators and uses thereof |
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CN107531631B (zh) | 2014-12-31 | 2021-09-03 | 安吉昂生物医药公司 | 用于治疗疾病的方法和药剂 |
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-
2005
- 2005-02-24 US US11/065,774 patent/US20050288340A1/en not_active Abandoned
- 2005-06-17 KR KR1020077001570A patent/KR20070030287A/ko not_active Application Discontinuation
- 2005-06-17 MX MX2007000289A patent/MX2007000289A/es unknown
- 2005-06-17 EP EP05755422A patent/EP1765796A1/en not_active Withdrawn
- 2005-06-17 JP JP2007519911A patent/JP2008505170A/ja active Pending
- 2005-06-17 EA EA200602273A patent/EA200602273A1/ru unknown
- 2005-06-17 CA CA002573193A patent/CA2573193A1/en not_active Abandoned
- 2005-06-17 CN CNA2005800252961A patent/CN101287718A/zh active Pending
- 2005-06-17 WO PCT/IB2005/002007 patent/WO2006003495A1/en active Application Filing
- 2005-06-17 BR BRPI0512624-0A patent/BRPI0512624A/pt not_active IP Right Cessation
- 2005-06-17 AP AP2007003889A patent/AP2007003889A0/xx unknown
- 2005-06-17 AU AU2005258906A patent/AU2005258906A1/en not_active Abandoned
- 2005-06-24 PE PE2005000739A patent/PE20060415A1/es not_active Application Discontinuation
- 2005-06-24 TW TW094121240A patent/TW200611690A/zh unknown
- 2005-06-27 UY UY28988A patent/UY28988A1/es not_active Application Discontinuation
- 2005-06-27 AR ARP050102637A patent/AR054665A1/es unknown
- 2005-06-27 GT GT200500173A patent/GT200500173A/es unknown
- 2005-06-28 NL NL1029360A patent/NL1029360C2/nl not_active IP Right Cessation
- 2005-06-29 PA PA20058638001A patent/PA8638001A1/es unknown
- 2005-06-29 SV SV2005002158A patent/SV2006002158A/es not_active Application Discontinuation
-
2006
- 2006-06-16 US US11/424,623 patent/US20060229363A1/en not_active Abandoned
- 2006-12-20 ZA ZA200610783A patent/ZA200610783B/en unknown
- 2006-12-28 IL IL180426A patent/IL180426A0/en unknown
- 2006-12-28 TN TNP2006000447A patent/TNSN06447A1/fr unknown
- 2006-12-28 EC EC2006007125A patent/ECSP067125A/es unknown
- 2006-12-29 MA MA29590A patent/MA28703B1/fr unknown
-
2007
- 2007-01-26 NO NO20070511A patent/NO20070511L/no not_active Application Discontinuation
- 2007-01-26 CR CR8881A patent/CR8881A/es not_active Application Discontinuation
- 2007-12-07 US US11/952,608 patent/US20080090829A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MA28703B1 (fr) | 2007-06-01 |
TNSN06447A1 (fr) | 2008-02-22 |
BRPI0512624A (pt) | 2008-03-25 |
UY28988A1 (es) | 2006-01-31 |
US20050288340A1 (en) | 2005-12-29 |
EP1765796A1 (en) | 2007-03-28 |
AU2005258906A1 (en) | 2006-01-12 |
NL1029360A1 (nl) | 2005-12-30 |
NO20070511L (no) | 2007-03-22 |
TW200611690A (en) | 2006-04-16 |
CR8881A (es) | 2007-03-19 |
MX2007000289A (es) | 2007-04-10 |
PA8638001A1 (es) | 2006-06-02 |
AP2007003889A0 (en) | 2007-02-28 |
GT200500173A (es) | 2006-03-02 |
JP2008505170A (ja) | 2008-02-21 |
US20060229363A1 (en) | 2006-10-12 |
CA2573193A1 (en) | 2006-01-12 |
KR20070030287A (ko) | 2007-03-15 |
SV2006002158A (es) | 2006-05-09 |
ZA200610783B (en) | 2008-06-25 |
ECSP067125A (es) | 2007-03-29 |
AR054665A1 (es) | 2007-07-11 |
US20080090829A1 (en) | 2008-04-17 |
IL180426A0 (en) | 2007-06-03 |
PE20060415A1 (es) | 2006-06-02 |
CN101287718A (zh) | 2008-10-15 |
WO2006003495A1 (en) | 2006-01-12 |
NL1029360C2 (nl) | 2006-07-12 |
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