EA200601215A1 - Фармацевтические композиции, содержащие метформин и фибрат, и способы их получения - Google Patents

Фармацевтические композиции, содержащие метформин и фибрат, и способы их получения

Info

Publication number
EA200601215A1
EA200601215A1 EA200601215A EA200601215A EA200601215A1 EA 200601215 A1 EA200601215 A1 EA 200601215A1 EA 200601215 A EA200601215 A EA 200601215A EA 200601215 A EA200601215 A EA 200601215A EA 200601215 A1 EA200601215 A1 EA 200601215A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
methormen
fibrat
methods
receiving
Prior art date
Application number
EA200601215A
Other languages
English (en)
Other versions
EA009773B1 (ru
Inventor
Гордон Даусон
Леонард Маккарти
Original Assignee
Фурнье Лабораториз Аеленд Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фурнье Лабораториз Аеленд Лимитед filed Critical Фурнье Лабораториз Аеленд Лимитед
Publication of EA200601215A1 publication Critical patent/EA200601215A1/ru
Publication of EA009773B1 publication Critical patent/EA009773B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к гранулятам, содержащим частицы метформина и частицы фибрата. Кроме того, данное изобретение относится к фармацевтическим композициям, содержащим такие грануляты. Изобретение также относится к способам получения гранулятов и фармацевтических композиций.
EA200601215A 2004-01-23 2005-01-24 Фармацевтические композиции, содержащие метформин и фибрат, и способы их получения EA009773B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04001499A EP1559419A1 (en) 2004-01-23 2004-01-23 Pharmaceutical formulations comprising metformin and a fibrate, and processes for their obtention
PCT/EP2005/001524 WO2005070396A1 (en) 2004-01-23 2005-01-24 Pharmaceutical formulations comprising metformin and a fibrate, and processes for obtaining them

Publications (2)

Publication Number Publication Date
EA200601215A1 true EA200601215A1 (ru) 2007-02-27
EA009773B1 EA009773B1 (ru) 2008-04-28

Family

ID=34639372

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601215A EA009773B1 (ru) 2004-01-23 2005-01-24 Фармацевтические композиции, содержащие метформин и фибрат, и способы их получения

Country Status (21)

Country Link
US (2) US20080020046A1 (ru)
EP (2) EP1559419A1 (ru)
JP (1) JP4740881B2 (ru)
CN (1) CN100531722C (ru)
AT (1) ATE521338T1 (ru)
AU (1) AU2005205930B2 (ru)
BR (1) BRPI0507022A (ru)
CA (1) CA2553967A1 (ru)
CY (1) CY1111961T1 (ru)
DK (1) DK1706102T3 (ru)
EA (1) EA009773B1 (ru)
ES (1) ES2370948T3 (ru)
IL (1) IL176903A0 (ru)
MA (1) MA28353A1 (ru)
NO (1) NO20062792L (ru)
PL (1) PL1706102T3 (ru)
PT (1) PT1706102E (ru)
SI (1) SI1706102T1 (ru)
TN (1) TNSN06222A1 (ru)
WO (1) WO2005070396A1 (ru)
ZA (1) ZA200605882B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600371A (es) * 2005-08-17 2007-03-21 Formas de dosis sólidas de valsartan y amlodipina y método para hacer las mismas
EP2026833A4 (en) * 2006-06-01 2012-05-30 Univ Vermont METHODS FOR INHIBITING CARDIAC PAI-1
CA2672686A1 (en) * 2006-10-12 2008-04-17 Abbott Laboratories Pharmaceutical formulations
CA2638240C (en) * 2008-08-29 2010-02-02 Alexander Macgregor Method of treating dysglycemia and glucose excursions
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
US10610489B2 (en) 2009-10-02 2020-04-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof
WO2011154013A1 (en) * 2010-06-10 2011-12-15 Lifecycle Pharma A/S Pharmaceutical composition comprising fenofibric acid
EA024925B1 (ru) * 2010-09-21 2016-11-30 Интекрин Терапьютикс, Инк. Антидиабетические твердые фармацевтические композиции
WO2013064853A1 (en) * 2011-11-05 2013-05-10 Lupin Atlantis Holdings, S.A. Reduced dose oral pharmaceutical compositions of fenofibrate
WO2013077821A1 (en) * 2011-11-23 2013-05-30 Mahmut Bilgic Homogeneous biguanide composition
WO2014091318A1 (en) * 2012-12-11 2014-06-19 Lupin Atlantis Holdings, S.A. Reduced dose pharmaceutical compositions of fenofibrate
MA41202A (fr) * 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
US10426745B2 (en) * 2015-03-06 2019-10-01 The University Of North Carolina At Chapel Hill Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle
EA201791982A1 (ru) 2015-03-09 2020-02-17 Интекрин Терапьютикс, Инк. Способы лечения неалкогольной жировой болезни печени и/или липодистрофии
CA3058806A1 (en) 2017-04-03 2018-10-11 Coherus Biosciences Inc. Ppar.gamma. agonist for treatment of progressive supranuclear palsy
EP4188352A1 (en) * 2020-07-31 2023-06-07 KRKA, d.d., Novo mesto Pharmaceutical formulation of metformin having low content of dimethylamine
WO2023234935A1 (en) * 2022-05-31 2023-12-07 Venkor Corporation Bonded microparticulates preparation and applications thereof

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US3907792A (en) * 1969-01-31 1975-09-23 Andre Mieville Phenoxy-alkyl-carboxylic acid derivatives and the preparation thereof
US4250191A (en) * 1978-11-30 1981-02-10 Edwards K David Preventing renal failure
US4499289A (en) * 1982-12-03 1985-02-12 G. D. Searle & Co. Octahydronapthalenes
US4686237A (en) * 1984-07-24 1987-08-11 Sandoz Pharmaceuticals Corp. Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
US5177080A (en) * 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
AU660852B2 (en) * 1992-11-25 1995-07-06 Elan Pharma International Limited Method of grinding pharmaceutical substances
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US5718388A (en) * 1994-05-25 1998-02-17 Eastman Kodak Continuous method of grinding pharmaceutical substances
TW384224B (en) * 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
US5662883A (en) * 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5560932A (en) * 1995-01-10 1996-10-01 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents
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Also Published As

Publication number Publication date
JP4740881B2 (ja) 2011-08-03
JP2007518773A (ja) 2007-07-12
US20080020046A1 (en) 2008-01-24
EP1706102B1 (en) 2011-08-24
PL1706102T3 (pl) 2012-01-31
CN1909890A (zh) 2007-02-07
ATE521338T1 (de) 2011-09-15
EP1706102A1 (en) 2006-10-04
CA2553967A1 (en) 2005-08-04
AU2005205930A1 (en) 2005-08-04
DK1706102T3 (da) 2011-12-19
IL176903A0 (en) 2006-12-10
EP1559419A1 (en) 2005-08-03
EA009773B1 (ru) 2008-04-28
TNSN06222A1 (en) 2007-12-03
CY1111961T1 (el) 2015-11-04
ZA200605882B (en) 2009-03-25
ES2370948T3 (es) 2011-12-26
US20110305733A1 (en) 2011-12-15
SI1706102T1 (sl) 2011-12-30
AU2005205930B2 (en) 2007-09-20
PT1706102E (pt) 2011-12-16
CN100531722C (zh) 2009-08-26
WO2005070396A1 (en) 2005-08-04
NO20062792L (no) 2006-09-25
MA28353A1 (fr) 2006-12-01
BRPI0507022A (pt) 2007-06-05

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ RU