EA200501666A1 - Композиция для улучшения познавательной способности и памяти - Google Patents

Композиция для улучшения познавательной способности и памяти

Info

Publication number
EA200501666A1
EA200501666A1 EA200501666A EA200501666A EA200501666A1 EA 200501666 A1 EA200501666 A1 EA 200501666A1 EA 200501666 A EA200501666 A EA 200501666A EA 200501666 A EA200501666 A EA 200501666A EA 200501666 A1 EA200501666 A1 EA 200501666A1
Authority
EA
Eurasian Patent Office
Prior art keywords
deterioration
melatonin
memory
insomnia
composition
Prior art date
Application number
EA200501666A
Other languages
English (en)
Other versions
EA008768B1 (ru
Inventor
Нава Зисапел
Моше Лаудон
Original Assignee
Неурим Фармасьютикэлс (1991) Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Неурим Фармасьютикэлс (1991) Лтд. filed Critical Неурим Фармасьютикэлс (1991) Лтд.
Publication of EA200501666A1 publication Critical patent/EA200501666A1/ru
Publication of EA008768B1 publication Critical patent/EA008768B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Abstract

Изобретение относится к фармакологически активной комбинации, применяемой при лечении больных, страдающих бессонницей, которая включает: (а) по меньшей мере один первый активный ингредиент, выбираемый из мелатонина, других мелатонергических агентов, агонистов мелатонина и антагонистов мелатонина; и (б) по меньшей мере один второй активный ингредиент, выбираемый из никотина и агонистов никотиновых рецепторов; к применению медикамента, содержащего компонент (а) с компонентом (б) или без него, для облегчения по меньшей мере одного отрицательного действия, выбираемого из ухудшения качества сна, ухудшения познавательной функции и ухудшения запоминающей функции, которое имеет место у больного в присутствии или отсутствии никотиновой заместительной терапии, а также к комплекту, применяемому для лечения больных, страдающих бессонницей, который включает компоненты (а) и (б) в форме разовой дозы.
EA200501666A 2003-04-29 2004-04-15 Композиция для улучшения познавательной способности и памяти EA008768B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL155666A IL155666A (en) 2003-04-29 2003-04-29 Insomnia treatment
PCT/IL2004/000330 WO2004096118A2 (en) 2003-04-29 2004-04-15 Composition for improving cognition and memory

Publications (2)

Publication Number Publication Date
EA200501666A1 true EA200501666A1 (ru) 2006-06-30
EA008768B1 EA008768B1 (ru) 2007-08-31

Family

ID=33397641

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501666A EA008768B1 (ru) 2003-04-29 2004-04-15 Композиция для улучшения познавательной способности и памяти

Country Status (29)

Country Link
US (2) US8859593B2 (ru)
EP (1) EP1620058B1 (ru)
JP (2) JP4981440B2 (ru)
KR (1) KR101136885B1 (ru)
CN (1) CN1787820B (ru)
AR (1) AR048370A1 (ru)
AT (1) ATE539746T1 (ru)
BR (1) BRPI0409935A (ru)
CA (1) CA2521182C (ru)
CL (1) CL2004000877A1 (ru)
CY (1) CY1112689T1 (ru)
DK (1) DK1620058T3 (ru)
EA (1) EA008768B1 (ru)
ES (1) ES2380364T3 (ru)
HK (1) HK1087635A1 (ru)
IL (1) IL155666A (ru)
IS (1) IS8090A (ru)
MX (1) MXPA05011590A (ru)
NO (1) NO333015B1 (ru)
NZ (1) NZ542724A (ru)
PE (1) PE20050144A1 (ru)
PL (1) PL1620058T3 (ru)
PT (1) PT1620058E (ru)
SI (1) SI1620058T1 (ru)
TW (1) TWI340037B (ru)
UA (1) UA87980C2 (ru)
UY (1) UY28296A1 (ru)
WO (1) WO2004096118A2 (ru)
ZA (1) ZA200509508B (ru)

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KR102317399B1 (ko) 2012-01-26 2021-10-26 반다 파마슈티칼즈, 인코퍼레이티드. 일주기 리듬 장애의 치료
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US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
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EP3777842A1 (en) 2016-10-31 2021-02-17 Neurim Pharmaceuticals Ltd. Melatonin mini-tablets and method of manufacturing the same
KR102499141B1 (ko) * 2016-10-31 2023-02-13 신신제약 주식회사 수면장애 치료용 경피흡수제제

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Also Published As

Publication number Publication date
NO333015B1 (no) 2013-02-18
PE20050144A1 (es) 2005-05-12
KR101136885B1 (ko) 2012-04-20
SI1620058T1 (sl) 2012-05-31
TW200501948A (en) 2005-01-16
CN1787820A (zh) 2006-06-14
NZ542724A (en) 2007-05-31
AR048370A1 (es) 2006-04-26
EP1620058A2 (en) 2006-02-01
JP2006525317A (ja) 2006-11-09
IL155666A (en) 2013-12-31
IL155666A0 (en) 2004-09-27
CA2521182C (en) 2011-05-31
JP4981440B2 (ja) 2012-07-18
DK1620058T3 (da) 2012-05-07
EP1620058B1 (en) 2012-01-04
MXPA05011590A (es) 2006-03-08
ATE539746T1 (de) 2012-01-15
ES2380364T3 (es) 2012-05-11
CN1787820B (zh) 2010-05-05
NO20055531L (no) 2005-11-23
KR20060005402A (ko) 2006-01-17
HK1087635A1 (en) 2006-10-20
UY28296A1 (es) 2004-11-30
JP2012116859A (ja) 2012-06-21
EP1620058A4 (en) 2006-07-26
EA008768B1 (ru) 2007-08-31
UA87980C2 (ru) 2009-09-10
CY1112689T1 (el) 2016-02-10
IS8090A (is) 2005-10-25
US20060229340A1 (en) 2006-10-12
WO2004096118B1 (en) 2005-12-01
TWI340037B (en) 2011-04-11
US8859593B2 (en) 2014-10-14
US20140378512A1 (en) 2014-12-25
CL2004000877A1 (es) 2005-01-07
CA2521182A1 (en) 2004-11-11
PT1620058E (pt) 2012-04-13
BRPI0409935A (pt) 2006-04-25
WO2004096118A3 (en) 2005-10-13
ZA200509508B (en) 2006-11-29
PL1620058T3 (pl) 2012-07-31
WO2004096118A2 (en) 2004-11-11

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