EA200501260A1 - Многофункциональные дендримеры и сверхразветвленные полимеры и их применение в качестве систем для доставки лекарств и генетического материала - Google Patents

Многофункциональные дендримеры и сверхразветвленные полимеры и их применение в качестве систем для доставки лекарств и генетического материала

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Publication number
EA200501260A1
EA200501260A1 EA200501260A EA200501260A EA200501260A1 EA 200501260 A1 EA200501260 A1 EA 200501260A1 EA 200501260 A EA200501260 A EA 200501260A EA 200501260 A EA200501260 A EA 200501260A EA 200501260 A1 EA200501260 A1 EA 200501260A1
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EA
Eurasian Patent Office
Prior art keywords
genetic material
multifunctional
systems
polymers
delivery systems
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Application number
EA200501260A
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English (en)
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Константинос Палеос
Димитриос Циоурвас
Ореоцили Сидератоу
Original Assignee
Нэйшнел Сентер Фо Сайнтифик Рисёч "Демокритос"
Константинос Палеос
Димитриос Циоурвас
Ореоцили Сидератоу
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Priority claimed from GR20030100194A external-priority patent/GR1004523B/el
Application filed by Нэйшнел Сентер Фо Сайнтифик Рисёч "Демокритос", Константинос Палеос, Димитриос Циоурвас, Ореоцили Сидератоу filed Critical Нэйшнел Сентер Фо Сайнтифик Рисёч "Демокритос"
Publication of EA200501260A1 publication Critical patent/EA200501260A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/005—Hyperbranched macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

Настоящее изобретение относится к синтезу многофункциональных дендримерных и сверхразветвленных полимеров, которые могут применяться в качестве систем доставки лекарственных средств, биологически активных фармацевтических соединений и в качестве систем доставки генов (носителей генетического материала), получаемых посредством конденсации с генетическим материалом. В частности, настоящее изобретение относится к синтезу многофункциональных соединений на основе подходящих дендримерных и сверхразветвленных полимеров, на терминальную поверхность которых вводятся функциональные группы X, Y и Z. Кроме того, для доставки генов в клетки эти многофункциональные системы катионизируют для образования комплексов с отрицательно заряженным генетическим материалом. Функциональные группы обеспечивают распознавание систем доставки комплементарными рецепторами клеток. Кроме того, они обеспечивают стабильность этих систем в биологической среде и способствуют их транспортировке через клеточные мембраны.
EA200501260A 2003-02-13 2004-02-13 Многофункциональные дендримеры и сверхразветвленные полимеры и их применение в качестве систем для доставки лекарств и генетического материала EA200501260A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GR20030100069 2003-02-13
GR20030100194A GR1004523B (el) 2003-05-02 2003-05-02 Πολυ-λειτουργικα δενδριμερικα και υπερδιακλαδισμενα πολυμερη ως φορεις γονιδιακου υλικου.
PCT/GR2004/000009 WO2004072153A1 (en) 2003-02-13 2004-02-13 Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems

Publications (1)

Publication Number Publication Date
EA200501260A1 true EA200501260A1 (ru) 2006-06-30

Family

ID=36968219

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501260A EA200501260A1 (ru) 2003-02-13 2004-02-13 Многофункциональные дендримеры и сверхразветвленные полимеры и их применение в качестве систем для доставки лекарств и генетического материала

Country Status (12)

Country Link
US (1) US20060204472A1 (ru)
EP (1) EP1603967A1 (ru)
JP (1) JP4808610B2 (ru)
KR (1) KR20050111586A (ru)
AU (1) AU2004211522B2 (ru)
BR (1) BRPI0407420A (ru)
CA (1) CA2516548A1 (ru)
EA (1) EA200501260A1 (ru)
IL (1) IL170060A (ru)
MX (1) MXPA05008579A (ru)
NZ (1) NZ574134A (ru)
WO (1) WO2004072153A1 (ru)

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DK1567195T3 (da) * 2002-11-26 2011-02-14 Upfront Chromatography As Dendrimerkonjugater til selektiv opløsning af proteinaggregater
JP4604220B2 (ja) * 2004-08-31 2011-01-05 学校法人慶應義塾 有機・有機金属化合物内包デンドリマー
CA2622021C (en) * 2005-09-14 2014-07-15 Wisconsin Alumni Research Foundation Composition comprising a dendrimer and the use thereof for binding phosphate
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
EP1940905B1 (de) 2005-10-25 2010-08-11 Evonik Degussa GmbH Präparate umfassend hyperverzweigte polymere
GR1006666B (el) * 2006-07-21 2010-01-19 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος" Μοριακοι δενδριτικοι φορεις με προσαρμοζομενη/μεταβαλλομενη διαλυτοτητα και συμπληρωματικοτητα προς μεμβρανικους υποδοχεις
CN100422228C (zh) * 2006-08-01 2008-10-01 苏州大学 含氟超支化-接枝嵌段聚合物及其制备
WO2008024435A2 (en) * 2006-08-23 2008-02-28 Vanderbilt University Dendritic molecular intracellular transporters and methods of making and using same
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MX2007013267A (es) * 2007-10-24 2009-05-11 Itesm Dendrimeros y dendrones multifuncionales con alta capacidad de carga.
US11254786B2 (en) 2007-11-05 2022-02-22 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
US20130142733A1 (en) 2007-11-05 2013-06-06 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
ES2744834T3 (es) 2007-11-05 2020-02-26 Univ Vanderbilt Nanopartículas degradables multifuncionales con control sobre el tamaño y las funcionalidades
DE102008000290A1 (de) 2008-02-13 2009-08-20 Evonik Degussa Gmbh Lagerstabile Produktsyteme für Prämixformulierungen
DE102008042923A1 (de) 2008-10-17 2010-04-22 Evonik Goldschmidt Gmbh Präparate zur gesteuerten Freisetzung von Wirkstoffen
DE102009028255A1 (de) 2009-08-05 2011-02-10 Evonik Degussa Gmbh Mikrostrukturierte multifunktionale anorganische Coating-Additive zur Vermeidung von Fouling (Biofilmbewuchs) bei aquatischen Anwendungen
DE102009036767A1 (de) 2009-08-08 2011-02-10 Evonik Degussa Gmbh Kompositpartikel für den Einsatz in der Mundhygiene
EP2311435A1 (en) 2009-10-07 2011-04-20 LEK Pharmaceuticals d.d. Pharmaceutical composition comprising poorly soluble active ingredient and hyperbranched polymer
EP2485716A2 (en) 2009-10-07 2012-08-15 LEK Pharmaceuticals d.d. Pharmaceutical composition comprising poorly soluble active ingredient and hyperbranched polymer
US8211450B2 (en) * 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
US8821630B2 (en) 2011-05-06 2014-09-02 W. R. Grace & Co.-Conn. Carboxylated-carboxylic polyglycerol compositions for use in cementitious compositions
US8519189B2 (en) 2011-06-01 2013-08-27 University Of British Columbia Polymers for reversing heparin-based anticoagulation
EP2804633A4 (en) 2012-01-18 2015-10-14 Univ Utah Res Found ARGININE-PREPARED BIODEGRADABLE POLYMERS WITH HIGH MOLECULAR WEIGHT
US10668161B2 (en) 2014-02-24 2020-06-02 The Regents Of The University Of California Therapeutic hyperbranched polyglycerol encapsulated biomolecules
US10208104B2 (en) * 2015-12-11 2019-02-19 The Chinese University Of Hong Kong Fast and efficient conjugation method based on thiourea-catechol coupling
CN111909364B (zh) * 2020-08-11 2022-05-17 常州美胜生物材料有限公司 一种银系抗菌母粒的制备方法
CN113230415B (zh) * 2021-05-18 2022-04-12 南华大学 岩藻糖与环糊精修饰多肽靶向动脉粥样硬化相关巨噬细胞纳米载体系统及其制备方法和应用
KR20230126566A (ko) 2022-02-23 2023-08-30 충남대학교산학협력단 핵수송 신호 펩타이드가 접합된 핵산 전달용 2세대 폴리아미도아민 덴드리머 고분자 유도체
CN115068697B (zh) * 2022-04-27 2023-05-16 浙江大学 一种基于超支化聚季铵盐的抗菌复合材料
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AU2004211522A1 (en) 2004-08-26
MXPA05008579A (es) 2007-11-21
US20060204472A1 (en) 2006-09-14
IL170060A (en) 2010-11-30
KR20050111586A (ko) 2005-11-25
AU2004211522B2 (en) 2010-01-28
EP1603967A1 (en) 2005-12-14
BRPI0407420A (pt) 2006-01-10
JP4808610B2 (ja) 2011-11-02
WO2004072153A1 (en) 2004-08-26
CA2516548A1 (en) 2004-08-26
JP2006518406A (ja) 2006-08-10
NZ574134A (en) 2011-03-31

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