BRPI0407420A - Dendrìmeros multifuncionais e polìmeros hiper-ramificados como sistemas de entrega de droga e gene - Google Patents

Dendrìmeros multifuncionais e polìmeros hiper-ramificados como sistemas de entrega de droga e gene

Info

Publication number
BRPI0407420A
BRPI0407420A BR0407420-3A BRPI0407420A BRPI0407420A BR PI0407420 A BRPI0407420 A BR PI0407420A BR PI0407420 A BRPI0407420 A BR PI0407420A BR PI0407420 A BRPI0407420 A BR PI0407420A
Authority
BR
Brazil
Prior art keywords
multifunctional
delivery systems
gene delivery
drug
systems
Prior art date
Application number
BR0407420-3A
Other languages
English (en)
Inventor
Constantinos Paleos
Dimitrios Tsiourvas
Oreozili Sideratou
Original Assignee
Nat Ct Scient Res Demokritos
Constantinos Paleos
Dimitrios Tsiourvas
Oreozili Sideratou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GR20030100194A external-priority patent/GR1004523B/el
Application filed by Nat Ct Scient Res Demokritos, Constantinos Paleos, Dimitrios Tsiourvas, Oreozili Sideratou filed Critical Nat Ct Scient Res Demokritos
Publication of BRPI0407420A publication Critical patent/BRPI0407420A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/005—Hyperbranched macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

"DENDRìMEROS MULTIFUNCIONAIS E POLìMEROS HIPER-RAMIFICADOS COMO SISTEMAS DE ENTREGA DE DROGA E GENE". A presente invenção se refere à síntese de polímeros dendriméricos multifuncionais e hiper-ramificados para aplicações como sistemas de entrega de droga de compostos farmacêuticos bioativos e como sistemas de entrega de gene (carreadores de material genético), esses últimos através da condensação com material genético. Especificamente, a presente invenção se refere à síntese de compostos multifuncionais baseados em polímeros dendriméricos ou hiper-ramificados apropriados, na superfície terminal dos quais foram introduzidos grupos funcionais X, Y, Z. Além disso, para entrega de gene às células, esses sistemas multifuncionais tornar-se-ão catiónicos para a formação de complexos com material genético negativamente carregado. Os grupos funcionais tornam os sistemas de entrega reconhecíveis pelos receptores de célula complementares. Adicionalmente, eles tornam os sistemas estáveis no meio biológico e facilitam seu transporte através de membranas de célula.
BR0407420-3A 2003-02-13 2004-02-13 Dendrìmeros multifuncionais e polìmeros hiper-ramificados como sistemas de entrega de droga e gene BRPI0407420A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GR20030100069 2003-02-13
GR20030100194A GR1004523B (el) 2003-05-02 2003-05-02 Πολυ-λειτουργικα δενδριμερικα και υπερδιακλαδισμενα πολυμερη ως φορεις γονιδιακου υλικου.
PCT/GR2004/000009 WO2004072153A1 (en) 2003-02-13 2004-02-13 Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems

Publications (1)

Publication Number Publication Date
BRPI0407420A true BRPI0407420A (pt) 2006-01-10

Family

ID=36968219

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0407420-3A BRPI0407420A (pt) 2003-02-13 2004-02-13 Dendrìmeros multifuncionais e polìmeros hiper-ramificados como sistemas de entrega de droga e gene

Country Status (12)

Country Link
US (1) US20060204472A1 (pt)
EP (1) EP1603967A1 (pt)
JP (1) JP4808610B2 (pt)
KR (1) KR20050111586A (pt)
AU (1) AU2004211522B2 (pt)
BR (1) BRPI0407420A (pt)
CA (1) CA2516548A1 (pt)
EA (1) EA200501260A1 (pt)
IL (1) IL170060A (pt)
MX (1) MXPA05008579A (pt)
NZ (1) NZ574134A (pt)
WO (1) WO2004072153A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60334726D1 (de) * 2002-11-26 2010-12-09 Upfront Chromatography As Kope Dendrimerkonjugate für selektive lösung von proteinaggregaten
JP4604220B2 (ja) * 2004-08-31 2011-01-05 学校法人慶應義塾 有機・有機金属化合物内包デンドリマー
CA2622021C (en) * 2005-09-14 2014-07-15 Wisconsin Alumni Research Foundation Composition comprising a dendrimer and the use thereof for binding phosphate
PL1940905T3 (pl) 2005-10-25 2011-02-28 Evonik Degussa Gmbh Preparaty zawierające hiperrozgałęzione polimery
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
GR1006666B (el) * 2006-07-21 2010-01-19 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος" Μοριακοι δενδριτικοι φορεις με προσαρμοζομενη/μεταβαλλομενη διαλυτοτητα και συμπληρωματικοτητα προς μεμβρανικους υποδοχεις
CN100422228C (zh) * 2006-08-01 2008-10-01 苏州大学 含氟超支化-接枝嵌段聚合物及其制备
US8969622B2 (en) * 2006-08-23 2015-03-03 Vanderbilt University Dendritic molecular intracellular transporters and methods of making and using same
WO2008071575A1 (en) * 2006-12-12 2008-06-19 Ciba Holding Inc. Flame retardant composition comprising dendritic polymers
MX2007013267A (es) 2007-10-24 2009-05-11 Itesm Dendrimeros y dendrones multifuncionales con alta capacidad de carga.
US20130142733A1 (en) 2007-11-05 2013-06-06 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
CA3007559C (en) 2007-11-05 2022-08-02 Vanderbilt University Methods of preparing epoxide-functionalized polymers
US11254786B2 (en) 2007-11-05 2022-02-22 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
DE102008000290A1 (de) 2008-02-13 2009-08-20 Evonik Degussa Gmbh Lagerstabile Produktsyteme für Prämixformulierungen
DE102008042923A1 (de) 2008-10-17 2010-04-22 Evonik Goldschmidt Gmbh Präparate zur gesteuerten Freisetzung von Wirkstoffen
DE102009028255A1 (de) 2009-08-05 2011-02-10 Evonik Degussa Gmbh Mikrostrukturierte multifunktionale anorganische Coating-Additive zur Vermeidung von Fouling (Biofilmbewuchs) bei aquatischen Anwendungen
DE102009036767A1 (de) 2009-08-08 2011-02-10 Evonik Degussa Gmbh Kompositpartikel für den Einsatz in der Mundhygiene
EP2311435A1 (en) 2009-10-07 2011-04-20 LEK Pharmaceuticals d.d. Pharmaceutical composition comprising poorly soluble active ingredient and hyperbranched polymer
CN102647978A (zh) 2009-10-07 2012-08-22 力奇制药公司 包含溶解性差的活性成分和高支化聚合物的药物组合物
US8211450B2 (en) * 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
US8821630B2 (en) 2011-05-06 2014-09-02 W. R. Grace & Co.-Conn. Carboxylated-carboxylic polyglycerol compositions for use in cementitious compositions
WO2012162789A1 (en) 2011-06-01 2012-12-06 University Of British Columbia Polymers for reversing heparin-based anticoagulation
US9907861B2 (en) 2012-01-18 2018-03-06 University Of Utah Research Foundation High molecular weight arginine-grafted bioreducible polymers
WO2015127347A1 (en) * 2014-02-24 2015-08-27 The Regents Of The University Of California Therapeutic hyperbranched polyglycerol encapsulated biomolecules
US10208104B2 (en) * 2015-12-11 2019-02-19 The Chinese University Of Hong Kong Fast and efficient conjugation method based on thiourea-catechol coupling
CN111909364B (zh) * 2020-08-11 2022-05-17 常州美胜生物材料有限公司 一种银系抗菌母粒的制备方法
CN113230415B (zh) * 2021-05-18 2022-04-12 南华大学 岩藻糖与环糊精修饰多肽靶向动脉粥样硬化相关巨噬细胞纳米载体系统及其制备方法和应用
KR20230126566A (ko) 2022-02-23 2023-08-30 충남대학교산학협력단 핵수송 신호 펩타이드가 접합된 핵산 전달용 2세대 폴리아미도아민 덴드리머 고분자 유도체
CN115068697B (zh) * 2022-04-27 2023-05-16 浙江大学 一种基于超支化聚季铵盐的抗菌复合材料
WO2023234837A1 (en) * 2022-05-31 2023-12-07 Polypeptide Laboratories Holding (Ppl) Ab Insoluble support for solid phase synthesis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163364C (en) * 1993-07-14 2009-10-27 Francis C. Szoka, Jr. Self-assembling polynucleotide delivery system comprising dendrimer polycations
AUPM623994A0 (en) * 1994-06-15 1994-07-07 Biomolecular Research Institute Limited Antiviral dendrimers
GB9718129D0 (en) * 1997-08-27 1997-10-29 Isis Innovation Branched structures
AUPP584398A0 (en) * 1998-09-14 1998-10-08 Starpharma Limited Inhibition of toxic materials or substances
US20040120979A1 (en) * 2000-06-02 2004-06-24 Roessler Blake J. Delivery systems comprising biocompatible and bioerodable membranes

Also Published As

Publication number Publication date
KR20050111586A (ko) 2005-11-25
EP1603967A1 (en) 2005-12-14
JP2006518406A (ja) 2006-08-10
US20060204472A1 (en) 2006-09-14
JP4808610B2 (ja) 2011-11-02
CA2516548A1 (en) 2004-08-26
AU2004211522B2 (en) 2010-01-28
EA200501260A1 (ru) 2006-06-30
IL170060A (en) 2010-11-30
WO2004072153A1 (en) 2004-08-26
AU2004211522A1 (en) 2004-08-26
MXPA05008579A (es) 2007-11-21
NZ574134A (en) 2011-03-31

Similar Documents

Publication Publication Date Title
BRPI0407420A (pt) Dendrìmeros multifuncionais e polìmeros hiper-ramificados como sistemas de entrega de droga e gene
Parsons et al. Guanidinium-functionalized interpolyelectrolyte complexes enabling RNAi in resistant insect pests
Latorre‐Sánchez et al. Recent bioinspired applications of single‐chain nanoparticles
Sideratou et al. Quaternized poly (propylene imine) dendrimers as novel pH-sensitive controlled-release systems
Hamidi et al. Novel aldehyde-terminated dendrimers; synthesis and cytotoxicity assay
Li et al. A novel 3D in vitro tumor model based on silk fibroin/chitosan scaffolds to mimic the tumor microenvironment
Kanayama et al. A PEG‐based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells
Kang et al. Design of polydiacetylene-phospholipid supramolecules for enhanced stability and sensitivity
Bermejo et al. Water‐soluble carbosilane dendrimers: synthesis biocompatibility and complexation with oligonucleotides; evaluation for medical applications
Chouai et al. Kilogram-scale synthesis of a second-generation dendrimer based on 1, 3, 5-triazine using green and industrially compatible methods with a single chromatographic step
Alamri et al. Biocidal polymers: synthesis and antimicrobial properties of benzaldehyde derivatives immobilized onto amine-terminated polyacrylonitrile
Zheng et al. High throughput screening of glycopolymers: balance between cytotoxicity and antibacterial property
Chen et al. Revisiting cationic phosphorus dendrimers as a nonviral vector for optimized gene delivery toward cancer therapy applications
Kuhlman et al. Interplay between PEO tether length and ligand spacing governs cell spreading on RGD-modified PMMA-g-PEO comb copolymers
Karthikeyan et al. Fabrication of electrospun zein nanofibers for the sustained delivery of siRNA
CN101939329A (zh) 以氨基酸配对为基础的自组装肽和方法
deRonde et al. Optimal hydrophobicity in ring-opening metathesis polymerization-based protein mimics required for siRNA internalization
Ismail et al. Mechanisms and regulation underlying membraneless organelle plasticity control
CN104004196A (zh) 一种可降解超支化聚酰胺胺的制备方法及其应用
Gupta et al. Structural design and synthesis of bimodal PNA that simultaneously binds two complementary DNAs to form fused double duplexes
Nottelet et al. Nanoaggregates of biodegradable amphiphilic random polycations for delivering water-insoluble drugs
Nagpal et al. Dendritic platforms for biomimicry and biotechnological applications
Diaz-Dussan et al. Oncogenic epidermal growth factor receptor silencing in cervical carcinoma mediated by dynamic sugar-benzoxaborole polyplexes
Lai et al. Nanomaterials of triazine-based dendrons: Convergent synthesis and their physical studies
Kench et al. Dimeric metal-salphen complexes which target multimeric G-quadruplex DNA

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.

B15K Others concerning applications: alteration of classification

Ipc: C12N 15/88 (2006.01), A61K 47/69 (2017.01), B82Y 5