EA200501064A1 - Гидрофильные, реакционные в отношении тиолгруппы цианиновые красители и их конъюгаты с биомолекулами для флюоресцентной диагностики - Google Patents

Гидрофильные, реакционные в отношении тиолгруппы цианиновые красители и их конъюгаты с биомолекулами для флюоресцентной диагностики

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Publication number
EA200501064A1
EA200501064A1 EA200501064A EA200501064A EA200501064A1 EA 200501064 A1 EA200501064 A1 EA 200501064A1 EA 200501064 A EA200501064 A EA 200501064A EA 200501064 A EA200501064 A EA 200501064A EA 200501064 A1 EA200501064 A1 EA 200501064A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dyes
biomolecules
conjugates
thiolgrupths
cyaninic
Prior art date
Application number
EA200501064A
Other languages
English (en)
Other versions
EA009386B1 (ru
Inventor
Кай Лиха
Кристин Перлитц
Original Assignee
Шеринг Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2003102787 external-priority patent/DE10302787A1/de
Application filed by Шеринг Акциенгезельшафт filed Critical Шеринг Акциенгезельшафт
Publication of EA200501064A1 publication Critical patent/EA200501064A1/ru
Publication of EA009386B1 publication Critical patent/EA009386B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/005—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a COOH and/or a functional derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к новым флюоресцентным красителям из класса цианиновых красителей, в частности индотрикарбоцианинам, с абсорбционным и флюоресцентным максимумом в спектральной области от 700 до 900 нм, со специфической в отношении тиольной группы реакционной группой и тремя, предпочтительно четырьмя, сульфонатными группами, к увеличению растворимости в воде, а также получению красителей. Настоящее изобретение относится также к конъюгатам этих красителей с биомолекулами и их применению.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200501064A 2003-01-24 2003-11-14 Гидрофильные, реакционные в отношении тиол-группы цианиновые красители, и их конъюгаты с биомолекулами для флюоресцентной диагностики EA009386B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2003102787 DE10302787A1 (de) 2003-01-24 2003-01-24 Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
US44319703P 2003-01-29 2003-01-29
PCT/EP2003/012735 WO2004065491A1 (en) 2003-01-24 2003-11-14 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis

Publications (2)

Publication Number Publication Date
EA200501064A1 true EA200501064A1 (ru) 2006-02-24
EA009386B1 EA009386B1 (ru) 2007-12-28

Family

ID=32773159

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501064A EA009386B1 (ru) 2003-01-24 2003-11-14 Гидрофильные, реакционные в отношении тиол-группы цианиновые красители, и их конъюгаты с биомолекулами для флюоресцентной диагностики

Country Status (17)

Country Link
US (1) US20040260072A1 (ru)
EP (1) EP1585791B1 (ru)
JP (1) JP2006513293A (ru)
KR (1) KR20050103907A (ru)
AT (1) ATE409209T1 (ru)
AU (1) AU2003292019A1 (ru)
BR (1) BR0318028A (ru)
CA (1) CA2514131A1 (ru)
CR (1) CR7925A (ru)
DE (1) DE60323766D1 (ru)
EA (1) EA009386B1 (ru)
EC (1) ECSP055975A (ru)
ES (1) ES2311736T3 (ru)
MX (1) MXPA05007668A (ru)
NZ (1) NZ541414A (ru)
PL (1) PL376459A1 (ru)
WO (1) WO2004065491A1 (ru)

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JP2011046663A (ja) * 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
KR101228147B1 (ko) * 2010-08-13 2013-01-31 국립암센터 방사성 동위원소가 표지되고 근적외선 영역의 형광색소 및 가시광선 영역의 색소가 결합된 알부민을 포함하는 감시림프절 표지자
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AU2015314954B2 (en) 2014-09-12 2021-05-13 Genentech, Inc. Anti-HER2 antibodies and immunoconjugates
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JP6752582B2 (ja) * 2016-02-08 2020-09-09 キヤノン株式会社 光音響イメージング用造影剤
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Also Published As

Publication number Publication date
PL376459A1 (en) 2005-12-27
EP1585791A1 (en) 2005-10-19
BR0318028A (pt) 2005-12-06
CR7925A (es) 2006-02-06
WO2004065491A1 (en) 2004-08-05
ES2311736T3 (es) 2009-02-16
CA2514131A1 (en) 2004-08-05
KR20050103907A (ko) 2005-11-01
EA009386B1 (ru) 2007-12-28
EP1585791B1 (en) 2008-09-24
DE60323766D1 (de) 2008-11-06
MXPA05007668A (es) 2005-09-30
ECSP055975A (es) 2006-01-16
AU2003292019A1 (en) 2004-08-13
US20040260072A1 (en) 2004-12-23
JP2006513293A (ja) 2006-04-20
ATE409209T1 (de) 2008-10-15
NZ541414A (en) 2007-12-21

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