DK1045918T3 - G protein-relaterede kinasemutanter i essentiel hypertension - Google Patents
G protein-relaterede kinasemutanter i essentiel hypertensionInfo
- Publication number
- DK1045918T3 DK1045918T3 DK99902201T DK99902201T DK1045918T3 DK 1045918 T3 DK1045918 T3 DK 1045918T3 DK 99902201 T DK99902201 T DK 99902201T DK 99902201 T DK99902201 T DK 99902201T DK 1045918 T3 DK1045918 T3 DK 1045918T3
- Authority
- DK
- Denmark
- Prior art keywords
- essential hypertension
- present
- protein
- related kinase
- kinase mutants
- Prior art date
Links
- 208000007530 Essential hypertension Diseases 0.000 title abstract 3
- 108091006027 G proteins Proteins 0.000 title 1
- 102000030782 GTP binding Human genes 0.000 title 1
- 108091000058 GTP-Binding Proteins 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000007876 drug discovery Methods 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 210000003292 kidney cell Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/054—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
- A01K2217/056—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to mutation of coding region of the transgene (dominant negative)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7119998P | 1998-01-12 | 1998-01-12 | |
| US9827998P | 1998-08-28 | 1998-08-28 | |
| PCT/US1999/000663 WO1999035279A1 (en) | 1998-01-12 | 1999-01-12 | G protein-related kinase mutants in essential hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1045918T3 true DK1045918T3 (da) | 2008-12-08 |
Family
ID=26751950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99902201T DK1045918T3 (da) | 1998-01-12 | 1999-01-12 | G protein-relaterede kinasemutanter i essentiel hypertension |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6660474B1 (da) |
| EP (2) | EP1045918B1 (da) |
| JP (2) | JP4652566B2 (da) |
| AT (1) | ATE405661T1 (da) |
| AU (1) | AU2223899A (da) |
| CA (1) | CA2318479C (da) |
| DE (1) | DE69939367D1 (da) |
| DK (1) | DK1045918T3 (da) |
| WO (1) | WO1999035279A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002214681A1 (en) * | 2000-10-31 | 2002-05-15 | Duke University | Hypertension |
| WO2002103020A1 (en) * | 2001-06-15 | 2002-12-27 | Takeda Chemical Industries, Ltd. | Novel disease-associated gene and use thereof |
| EP1472540A4 (en) * | 2001-12-19 | 2005-08-03 | Millennium Pharm Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF PAIN AND PAINFUL DISORDERS USING 1465, 1587, 2146, 2207, 32838, 336 AND 52908 |
| WO2005093096A1 (es) * | 2004-03-29 | 2005-10-06 | Universitat Pompeu Fabra | Método y kit para la detección del riesgo de padecer hipertensión |
| WO2005114195A1 (en) * | 2004-05-21 | 2005-12-01 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor kinase 4 (grk4) |
| CN100465288C (zh) * | 2005-08-10 | 2009-03-04 | 中国医学科学院阜外心血管病医院 | 检测与人类原发性高血压相关的grk4基因多态的方法 |
| US20080268442A1 (en) * | 2007-04-24 | 2008-10-30 | Igd Intel, Llc | Method and system for preparing a blood sample for a disease association gene transcript test |
| US8135545B2 (en) | 2007-11-09 | 2012-03-13 | Iverson Genetic Diagnostics, Inc. | System and method for collecting data regarding broad-based neurotoxin-related gene mutation association |
| US20090125244A1 (en) * | 2007-11-09 | 2009-05-14 | Igd Intel Llc | Broad-based neurotoxin-related gene mutation association from a gene transcript test |
| US9784726B2 (en) | 2013-01-08 | 2017-10-10 | Atrogi Ab | Screening method, a kit, a method of treatment and a compound for use in a method of treatment |
| US9657348B2 (en) | 2013-01-13 | 2017-05-23 | Atrogi Ab | Method of screening compounds for the treatment of diabetes |
| US9891212B2 (en) | 2013-12-16 | 2018-02-13 | Atrogi Ab | Screening method, a kit, a method of treatment and a compound for use in a method of treatment |
| CN105296488B (zh) * | 2015-12-02 | 2018-05-01 | 中国人民解放军第三军医大学第三附属医院 | 超声微泡介导的siRNA干扰GRK4在靶向调节尿钠排泄及血压水平中的应用 |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| CN107881226A (zh) * | 2017-10-30 | 2018-04-06 | 广东药科大学 | Scad基因或scad蛋白在制备防治血管重构和重大血管疾病药物中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| EP0289121B1 (en) | 1987-05-01 | 1995-12-27 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences |
| US5221778A (en) | 1988-08-24 | 1993-06-22 | Yale University | Multiplex gene regulation |
| US5098890A (en) | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5087617A (en) | 1989-02-15 | 1992-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| US5175383A (en) | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5166195A (en) | 1990-05-11 | 1992-11-24 | Isis Pharmaceuticals, Inc. | Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides |
| US5614396A (en) | 1990-06-14 | 1997-03-25 | Baylor College Of Medicine | Methods for the genetic modification of endogenous genes in animal cells by homologous recombination |
| JPH06507782A (ja) | 1990-06-15 | 1994-09-08 | サイオス ノバ インコーポレイテッド | アルツハイマー病のアミロイド形成開症状を示すヒト以外の組換え哺乳動物 |
| US5135917A (en) | 1990-07-12 | 1992-08-04 | Nova Pharmaceutical Corporation | Interleukin receptor expression inhibiting antisense oligonucleotides |
| US5288846A (en) | 1990-10-19 | 1994-02-22 | The General Hospital Corporation | Cell specific gene regulators |
| DE4126968A1 (de) | 1991-08-14 | 1993-02-18 | Detlev Prof Dr Med Ganten | Transgene ratten, die in ihrem genom mindestens ein menschliches gen enthalten, das an der blutdruckregulation beteiligt ist |
| US5298422A (en) | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
| WO1993014200A1 (en) | 1992-01-07 | 1993-07-22 | Tsi Corporation | Transgenic animal models for alzheimer's disease |
| WO1994006908A1 (en) | 1992-09-11 | 1994-03-31 | The Regents Of The University Of California | Transgenic non-human animals having targeted lymphocyte transduction genes |
| EP0673252A4 (en) | 1992-12-14 | 1998-07-15 | Start Technology Partnership | ADMINISTRATION OF ANTISENSE OLIGONUCLEOTIDES TO THE DOPAMIN RECEPTOR RNA MESSENGER FOR DIAGNOSING AND TREATING NEUROLOGICAL CONDITIONS. |
| WO1994023049A2 (en) | 1993-04-02 | 1994-10-13 | The Johns Hopkins University | The introduction and expression of large genomic sequences in transgenic animals |
| US6664107B1 (en) | 1993-05-26 | 2003-12-16 | Ontario Cancer Institute, University Health Network | CD45 disrupted nucleic acid |
| US5856103A (en) | 1994-10-07 | 1999-01-05 | Board Of Regents The University Of Texas | Method for selectively ranking sequences for antisense targeting |
| US5783683A (en) | 1995-01-10 | 1998-07-21 | Genta Inc. | Antisense oligonucleotides which reduce expression of the FGFRI gene |
| US5834248A (en) | 1995-02-10 | 1998-11-10 | Millennium Pharmaceuticals Inc. | Compositions and methods using rchd534, a gene uregulated by shear stress |
| NO953680D0 (no) | 1995-09-18 | 1995-09-18 | Hans Prydz | Cellesyklusenzymer |
| JPH11507245A (ja) | 1995-11-21 | 1999-06-29 | アイシーエヌ・ファーマシューティカルズ・インコーポレイテッド | Ｉｌ―８およびｉｌ―８受容体に対するアンチセンスオリゴヌクレオチドによる睡瘍増殖の阻害 |
| US5856099A (en) | 1996-05-21 | 1999-01-05 | Isis Pharmaceuticals, Inc. | Antisense compositions and methods for modulating type I interleukin-1 receptor expression |
-
1999
- 1999-01-12 AU AU22238/99A patent/AU2223899A/en not_active Abandoned
- 1999-01-12 WO PCT/US1999/000663 patent/WO1999035279A1/en active Application Filing
- 1999-01-12 AT AT99902201T patent/ATE405661T1/de not_active IP Right Cessation
- 1999-01-12 CA CA002318479A patent/CA2318479C/en not_active Expired - Fee Related
- 1999-01-12 JP JP2000527662A patent/JP4652566B2/ja not_active Expired - Fee Related
- 1999-01-12 EP EP99902201A patent/EP1045918B1/en not_active Expired - Lifetime
- 1999-01-12 DK DK99902201T patent/DK1045918T3/da active
- 1999-01-12 DE DE69939367T patent/DE69939367D1/de not_active Expired - Lifetime
- 1999-01-12 EP EP08162553A patent/EP2009109A1/en not_active Withdrawn
-
2000
- 2000-07-12 US US09/614,748 patent/US6660474B1/en not_active Expired - Lifetime
-
2003
- 2003-10-02 US US10/677,983 patent/US20050089871A1/en not_active Abandoned
-
2008
- 2008-12-01 US US12/315,338 patent/US9074016B2/en not_active Expired - Fee Related
-
2010
- 2010-09-06 JP JP2010199161A patent/JP5340242B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5340242B2 (ja) | 2013-11-13 |
| JP4652566B2 (ja) | 2011-03-16 |
| JP2011036253A (ja) | 2011-02-24 |
| US20100313286A1 (en) | 2010-12-09 |
| EP1045918B1 (en) | 2008-08-20 |
| EP2009109A1 (en) | 2008-12-31 |
| AU2223899A (en) | 1999-07-26 |
| DE69939367D1 (de) | 2008-10-02 |
| CA2318479A1 (en) | 1999-07-15 |
| US20050089871A1 (en) | 2005-04-28 |
| EP1045918A1 (en) | 2000-10-25 |
| ATE405661T1 (de) | 2008-09-15 |
| US6660474B1 (en) | 2003-12-09 |
| WO1999035279A1 (en) | 1999-07-15 |
| EP1045918A4 (en) | 2003-10-08 |
| CA2318479C (en) | 2009-03-24 |
| JP2002508157A (ja) | 2002-03-19 |
| US9074016B2 (en) | 2015-07-07 |
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