EA200401261A1 - Способ производства сертиндола - Google Patents

Способ производства сертиндола

Info

Publication number
EA200401261A1
EA200401261A1 EA200401261A EA200401261A EA200401261A1 EA 200401261 A1 EA200401261 A1 EA 200401261A1 EA 200401261 A EA200401261 A EA 200401261A EA 200401261 A EA200401261 A EA 200401261A EA 200401261 A1 EA200401261 A1 EA 200401261A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fluorophenyl
copper
sertindole
indole
chloro
Prior art date
Application number
EA200401261A
Other languages
English (en)
Other versions
EA007009B1 (ru
Inventor
Джакопо Дзанон
Марко Вилла
Франческо Чьярделла
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200401261A1 publication Critical patent/EA200401261A1/ru
Publication of EA007009B1 publication Critical patent/EA007009B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новому способу производства сертиндола, включающему производство 5-хлор-1-(4-фторфенил)индола и превращение его в сертиндол, где способ производства 5-хлор-1-(4-фторфенил)индола включает взаимодействие 5-хлориндола с 4-фторфенилгалогенидом в присутствии основания, хелатообразующего лиганда и каталитических количеств соли меди, содержащей медь(I) или медь(II) и анион, который не препятствует каким-либо неблагоприятным образом реакции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401261A 2002-03-27 2003-03-26 Способ производства сертиндола EA007009B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200200480 2002-03-27
PCT/DK2003/000208 WO2003080597A1 (en) 2002-03-27 2003-03-26 Method for manufacture of sertindole

Publications (2)

Publication Number Publication Date
EA200401261A1 true EA200401261A1 (ru) 2005-02-24
EA007009B1 EA007009B1 (ru) 2006-06-30

Family

ID=37952025

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401261A EA007009B1 (ru) 2002-03-27 2003-03-26 Способ производства сертиндола

Country Status (17)

Country Link
EP (2) EP1661887A1 (ru)
JP (1) JP2005531519A (ru)
KR (1) KR20040095332A (ru)
CN (1) CN100528863C (ru)
AR (1) AR039116A1 (ru)
AU (1) AU2003215528B2 (ru)
BR (1) BR0308627A (ru)
CA (1) CA2480239C (ru)
CO (1) CO5611197A2 (ru)
EA (1) EA007009B1 (ru)
ME (1) MEP6008A (ru)
NZ (1) NZ535533A (ru)
PL (1) PL371585A1 (ru)
RS (1) RS85004A (ru)
UA (1) UA78300C2 (ru)
WO (1) WO2003080597A1 (ru)
ZA (1) ZA200408273B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1863752A (zh) * 2002-08-02 2006-11-15 罗迪亚药业公司 铜催化的芳基化
US8069775B2 (en) 2006-07-07 2011-12-06 Plast 2000 S.R.L. Brewing apparatus and process for making infusions or beverages, particularly espresso
CN101591330B (zh) * 2009-06-29 2013-03-06 上海医药工业研究院 舍吲哚晶型及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
CN1243001C (zh) * 1997-05-09 2006-02-22 H·隆德贝克有限公司 制造司提多尔的方法
US6395939B1 (en) * 1997-10-06 2002-05-28 Massachusetts Institute Of Technology Diaryl ether condensation reactions

Also Published As

Publication number Publication date
EP1490353A1 (en) 2004-12-29
PL371585A1 (en) 2005-06-27
KR20040095332A (ko) 2004-11-12
ZA200408273B (en) 2006-07-26
CA2480239A1 (en) 2003-10-02
EA007009B1 (ru) 2006-06-30
AR039116A1 (es) 2005-02-09
CN1642942A (zh) 2005-07-20
JP2005531519A (ja) 2005-10-20
AU2003215528B2 (en) 2009-05-28
CA2480239C (en) 2010-11-23
RS85004A (en) 2006-12-15
CN100528863C (zh) 2009-08-19
WO2003080597A1 (en) 2003-10-02
EP1661887A1 (en) 2006-05-31
AU2003215528A1 (en) 2003-10-08
NZ535533A (en) 2007-01-26
MEP6008A (xx) 2010-02-10
BR0308627A (pt) 2005-02-15
UA78300C2 (en) 2007-03-15
CO5611197A2 (es) 2006-02-28

Similar Documents

Publication Publication Date Title
EP1553975A4 (en) OPTIMIZED FC VARIANTS AND MANUFACTURING METHOD THEREFOR
Iqbal et al. Formation of Carbonyl Compounds from Amines through Oxidative C N Bond Cleavage using Visible Light Photocatalysis and Applications to N‐PMB‐Amide Deprotection
TR200100006T2 (tr) Bir katalizör terkibi, ve bunu hazırlamak ve bir polimerizasyon işleminde kullanmak için yöntemler
NO20070391L (no) Jernsulfatbasert fosfatadsorbent
DK1562444T3 (da) Fremgangsmåde til formindskelse af acrylamidindholdet i varmebehandlede levnedsmidler
RU2008100766A (ru) Хиназолиновые соединения
DK1311482T3 (da) Ikke-imidazolaryloxypiperidiner som H3-receptorligander
UA87561C2 (ru) Способ получения замещенных бифенилов
NO20085164L (no) Blyfri primaersprengstoffblanding og fremgangsmate for fremstilling derav
EA201170168A1 (ru) Комплекс (минерал-аминокислота)-полисахарид
EA200800889A1 (ru) Гексагидроциклооктилпиразольные каннабиноидные модуляторы
DE602006007044D1 (de) Epoxidierungsverfahren umfassend einen polymerverkapselten edelmetallkatalysator, der ein ionenaustauscherharz umfasst
ATE294164T1 (de) Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening
CY1113871T1 (el) Διαδικασια παρασκευης γκαμπαπεντινης
EA200401261A1 (ru) Способ производства сертиндола
IS8249A (is) Tafla sem felur í sér flúvastatín og karmellósakalsíum
SE9802705L (sv) Förfarande för pappersframställning
DE59903314D1 (de) Perfluor-n-alkansulfonsäure-derivate
HUP0401916A2 (hu) Eljárás fenolos vegyületek nitrálására
EA200800723A1 (ru) Способ получения анилинов
TR199802146T2 (xx) Saf azetidin-2-karboksilik asitin �retilmesi i�in geli�tirilmi� y�ntem
ES2182342T3 (es) Procedimiento para producir derivados de indol.
ES2196250T3 (es) Procedimiento para la obtencion de (r o s)-1- (4 metoxibencil) 1,2,3,4,5,6,7,8-octahidro-isoquinolina opticamente activa.
IL162237A (en) Method for the arylation of olefins
HRPK20070120B3 (en) Method for manufacture of sertindole

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU