RS85004A - Method for manufacture of sertindole - Google Patents

Method for manufacture of sertindole

Info

Publication number
RS85004A
RS85004A YU85004A YUP85004A RS85004A RS 85004 A RS85004 A RS 85004A YU 85004 A YU85004 A YU 85004A YU P85004 A YUP85004 A YU P85004A RS 85004 A RS85004 A RS 85004A
Authority
RS
Serbia
Prior art keywords
sertindole
manufacture
chloro
indole
copper
Prior art date
Application number
YU85004A
Other languages
English (en)
Inventor
Jacopo Zanon
Marco Villa
Francesco Ciardella
Original Assignee
H.Lundbeck A/S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S. filed Critical H.Lundbeck A/S.
Publication of RS85004A publication Critical patent/RS85004A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Sadašnji pronalazak se odnosi na novi postupak proizvodnje sertindola koji se sastoji od proizvodnje 5 hloro-1-(4-fluorofenil)-indola i njegovog pretvaranja u sertindol pri čerou se postupak proizvodnje 5-hloro-1-(4-fluorofenil)-indola sastoji od reagovanja 5-hloro-indola sa 4-fluorofenilhalidom u prisustvu baze, helatujućeg liganda i katalitičkih količina soli bakra koja sadrži bakar (I) ili bakar (II) i anjon koji se ne meša na neželjeni način sa reakcijom.
YU85004A 2002-03-27 2003-03-26 Method for manufacture of sertindole RS85004A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36843402P 2002-03-27 2002-03-27
DKPA200200480 2002-03-27
PCT/DK2003/000208 WO2003080597A1 (en) 2002-03-27 2003-03-26 Method for manufacture of sertindole

Publications (1)

Publication Number Publication Date
RS85004A true RS85004A (en) 2006-12-15

Family

ID=37952025

Family Applications (1)

Application Number Title Priority Date Filing Date
YU85004A RS85004A (en) 2002-03-27 2003-03-26 Method for manufacture of sertindole

Country Status (17)

Country Link
EP (2) EP1490353A1 (sr)
JP (1) JP2005531519A (sr)
KR (1) KR20040095332A (sr)
CN (1) CN100528863C (sr)
AR (1) AR039116A1 (sr)
AU (1) AU2003215528B2 (sr)
BR (1) BR0308627A (sr)
CA (1) CA2480239C (sr)
CO (1) CO5611197A2 (sr)
EA (1) EA007009B1 (sr)
ME (1) MEP6008A (sr)
NZ (1) NZ535533A (sr)
PL (1) PL371585A1 (sr)
RS (1) RS85004A (sr)
UA (1) UA78300C2 (sr)
WO (1) WO2003080597A1 (sr)
ZA (1) ZA200408273B (sr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060149076A1 (en) * 2002-08-02 2006-07-06 Frederick Hicks Copper catalyzed arylation
MX2009000260A (es) 2006-07-07 2009-04-07 Plast 2000 S R L Aparato de preparacion y proceso para elaborar infusiones o bebidas, paricularmente cafe expreso.
CN101591330B (zh) * 2009-06-29 2013-03-06 上海医药工业研究院 舍吲哚晶型及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
KR100546477B1 (ko) * 1997-05-09 2006-01-26 하. 룬트벡 아크티에 셀스카브 세르틴돌의 제조방법
US6395939B1 (en) * 1997-10-06 2002-05-28 Massachusetts Institute Of Technology Diaryl ether condensation reactions

Also Published As

Publication number Publication date
ZA200408273B (en) 2006-07-26
EP1490353A1 (en) 2004-12-29
EA200401261A1 (ru) 2005-02-24
EA007009B1 (ru) 2006-06-30
NZ535533A (en) 2007-01-26
AU2003215528A1 (en) 2003-10-08
MEP6008A (xx) 2010-02-10
KR20040095332A (ko) 2004-11-12
CA2480239A1 (en) 2003-10-02
EP1661887A1 (en) 2006-05-31
CO5611197A2 (es) 2006-02-28
WO2003080597A1 (en) 2003-10-02
BR0308627A (pt) 2005-02-15
CN1642942A (zh) 2005-07-20
CA2480239C (en) 2010-11-23
JP2005531519A (ja) 2005-10-20
AR039116A1 (es) 2005-02-09
AU2003215528B2 (en) 2009-05-28
UA78300C2 (en) 2007-03-15
PL371585A1 (en) 2005-06-27
CN100528863C (zh) 2009-08-19

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