EA200401261A1 - METHOD OF MANUFACTURING SERTINDOL - Google Patents

METHOD OF MANUFACTURING SERTINDOL

Info

Publication number
EA200401261A1
EA200401261A1 EA200401261A EA200401261A EA200401261A1 EA 200401261 A1 EA200401261 A1 EA 200401261A1 EA 200401261 A EA200401261 A EA 200401261A EA 200401261 A EA200401261 A EA 200401261A EA 200401261 A1 EA200401261 A1 EA 200401261A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fluorophenyl
copper
sertindole
indole
chloro
Prior art date
Application number
EA200401261A
Other languages
Russian (ru)
Other versions
EA007009B1 (en
Inventor
Джакопо Дзанон
Марко Вилла
Франческо Чьярделла
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200401261A1 publication Critical patent/EA200401261A1/en
Publication of EA007009B1 publication Critical patent/EA007009B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новому способу производства сертиндола, включающему производство 5-хлор-1-(4-фторфенил)индола и превращение его в сертиндол, где способ производства 5-хлор-1-(4-фторфенил)индола включает взаимодействие 5-хлориндола с 4-фторфенилгалогенидом в присутствии основания, хелатообразующего лиганда и каталитических количеств соли меди, содержащей медь(I) или медь(II) и анион, который не препятствует каким-либо неблагоприятным образом реакции.Международная заявка была опубликована вместе с отчетом о международном поиске.The present invention relates to a new method of production of sertindole, including the production of 5-chloro-1- (4-fluorophenyl) indole and its transformation into sertindole, where the method of producing 5-chloro-1- (4-fluorophenyl) indole involves the interaction of 5-chloroindole with 4-fluorophenyl halide in the presence of a base, a chelating ligand, and catalytic amounts of a copper salt containing copper (I) or copper (II) and an anion that does not interfere in any adverse reaction. The international application was published along with an international report sk.

EA200401261A 2002-03-27 2003-03-26 Method for manufacture of sertindole EA007009B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200200480 2002-03-27
PCT/DK2003/000208 WO2003080597A1 (en) 2002-03-27 2003-03-26 Method for manufacture of sertindole

Publications (2)

Publication Number Publication Date
EA200401261A1 true EA200401261A1 (en) 2005-02-24
EA007009B1 EA007009B1 (en) 2006-06-30

Family

ID=37952025

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401261A EA007009B1 (en) 2002-03-27 2003-03-26 Method for manufacture of sertindole

Country Status (17)

Country Link
EP (2) EP1490353A1 (en)
JP (1) JP2005531519A (en)
KR (1) KR20040095332A (en)
CN (1) CN100528863C (en)
AR (1) AR039116A1 (en)
AU (1) AU2003215528B2 (en)
BR (1) BR0308627A (en)
CA (1) CA2480239C (en)
CO (1) CO5611197A2 (en)
EA (1) EA007009B1 (en)
ME (1) MEP6008A (en)
NZ (1) NZ535533A (en)
PL (1) PL371585A1 (en)
RS (1) RS85004A (en)
UA (1) UA78300C2 (en)
WO (1) WO2003080597A1 (en)
ZA (1) ZA200408273B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050032585A (en) * 2002-08-02 2005-04-07 로디아 파마 솔루션즈 인코포레이티드 Copper catalyzed arylation
DE602007008422D1 (en) 2006-07-07 2010-09-23 Plast 2000 S R L BREWING DEVICE AND METHOD FOR PREPARING SPICES OR BEVERAGES, ESPECIALLY ESPRESSO
CN101591330B (en) * 2009-06-29 2013-03-06 上海医药工业研究院 Sertindole crystal form and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
SK285221B6 (en) * 1997-05-09 2006-09-07 H. Lundbeck A/S Method of manufacturing sertindole and their intermediates
WO1999018057A1 (en) * 1997-10-06 1999-04-15 Massachusetts Institute Of Technology Preparation of diaryl ether by condensation reactions

Also Published As

Publication number Publication date
AU2003215528A1 (en) 2003-10-08
EP1490353A1 (en) 2004-12-29
WO2003080597A1 (en) 2003-10-02
BR0308627A (en) 2005-02-15
CO5611197A2 (en) 2006-02-28
CN1642942A (en) 2005-07-20
JP2005531519A (en) 2005-10-20
PL371585A1 (en) 2005-06-27
KR20040095332A (en) 2004-11-12
UA78300C2 (en) 2007-03-15
ZA200408273B (en) 2006-07-26
RS85004A (en) 2006-12-15
CA2480239C (en) 2010-11-23
AR039116A1 (en) 2005-02-09
CN100528863C (en) 2009-08-19
MEP6008A (en) 2010-02-10
CA2480239A1 (en) 2003-10-02
AU2003215528B2 (en) 2009-05-28
EP1661887A1 (en) 2006-05-31
NZ535533A (en) 2007-01-26
EA007009B1 (en) 2006-06-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU