HRPK20070120B3 - Method for manufacture of sertindole - Google Patents
Method for manufacture of sertindoleInfo
- Publication number
- HRPK20070120B3 HRPK20070120B3 HR20070120A HRP20070120A HRPK20070120B3 HR PK20070120 B3 HRPK20070120 B3 HR PK20070120B3 HR 20070120 A HR20070120 A HR 20070120A HR P20070120 A HRP20070120 A HR P20070120A HR PK20070120 B3 HRPK20070120 B3 HR PK20070120B3
- Authority
- HR
- Croatia
- Prior art keywords
- sertindole
- chloro
- indole
- fluorophenyl
- copper
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000652 sertindole Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 3
- JYEKQDWSLSXYTJ-UHFFFAOYSA-N 5-chloro-1-(4-fluorophenyl)indole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C=C1 JYEKQDWSLSXYTJ-UHFFFAOYSA-N 0.000 abstract 2
- -1 4-fluorophenyl halide Chemical class 0.000 abstract 1
- MYTGFBZJLDLWQG-UHFFFAOYSA-N 5-chloro-1h-indole Chemical compound ClC1=CC=C2NC=CC2=C1 MYTGFBZJLDLWQG-UHFFFAOYSA-N 0.000 abstract 1
- VMQMZMRVKUZKQL-UHFFFAOYSA-N Cu+ Chemical compound [Cu+] VMQMZMRVKUZKQL-UHFFFAOYSA-N 0.000 abstract 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 150000001879 copper Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Način dobivanja sertindola koji podrazumijeva dobivanje 5-kloro-1-(4-fluorofenil)-indola i njegovu konverziju u sertindol, naznačen time da način dobivanja 5-kloro-1-(4-fluorofenil)-indola sadrži reakciju na 5-kloro-indol s 4-fluorofenilhalidom uz prisutnost baze, liganda koji stvara prstenastu strukturu i katalitičkih količina bakrene soli koja sadrži bakar(I) ili bakar(II) te aniona koji ne interferira nepovoljno s reakcijom. Patent sadrži još 11 patentnih zahtjeva.A process for the preparation of sertindole, which comprises the preparation of 5-chloro-1- (4-fluorophenyl) -indole and its conversion to sertindole, wherein the method of preparing 5-chloro-1- (4-fluorophenyl) -indole comprises a reaction to 5-chloro- indole with 4-fluorophenyl halide in the presence of a base, a ring-forming ligand and catalytic amounts of a copper salt containing copper (I) or copper (II) and an anion which does not interfere unfavorably with the reaction. The patent contains 11 more claims.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR20070120A HRPK20070120B3 (en) | 2007-03-23 | 2007-03-23 | Method for manufacture of sertindole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR20070120A HRPK20070120B3 (en) | 2007-03-23 | 2007-03-23 | Method for manufacture of sertindole |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20070120A2 HRP20070120A2 (en) | 2008-10-31 |
HRPK20070120B3 true HRPK20070120B3 (en) | 2009-09-30 |
Family
ID=39876485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20070120A HRPK20070120B3 (en) | 2007-03-23 | 2007-03-23 | Method for manufacture of sertindole |
Country Status (1)
Country | Link |
---|---|
HR (1) | HRPK20070120B3 (en) |
-
2007
- 2007-03-23 HR HR20070120A patent/HRPK20070120B3/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HRP20070120A2 (en) | 2008-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1OB | Publication of a patent application | ||
AKOB | Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent) | ||
PKB1 | Consensual patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20120229 Year of fee payment: 6 |
|
PBKO | Lapse due to non-payment of renewal fee for consensual patent |
Effective date: 20130324 |