HRPK20070120B3 - Method for manufacture of sertindole - Google Patents

Method for manufacture of sertindole

Info

Publication number
HRPK20070120B3
HRPK20070120B3 HR20070120A HRP20070120A HRPK20070120B3 HR PK20070120 B3 HRPK20070120 B3 HR PK20070120B3 HR 20070120 A HR20070120 A HR 20070120A HR P20070120 A HRP20070120 A HR P20070120A HR PK20070120 B3 HRPK20070120 B3 HR PK20070120B3
Authority
HR
Croatia
Prior art keywords
sertindole
chloro
indole
fluorophenyl
copper
Prior art date
Application number
HR20070120A
Other languages
Croatian (hr)
Inventor
Zanon Jacopo
Villa Marco
Ciardella Francesco
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Priority to HR20070120A priority Critical patent/HRPK20070120B3/en
Publication of HRP20070120A2 publication Critical patent/HRP20070120A2/en
Publication of HRPK20070120B3 publication Critical patent/HRPK20070120B3/en

Links

Landscapes

  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Način dobivanja sertindola koji podrazumijeva dobivanje 5-kloro-1-(4-fluorofenil)-indola i njegovu konverziju u sertindol, naznačen time da način dobivanja 5-kloro-1-(4-fluorofenil)-indola sadrži reakciju na 5-kloro-indol s 4-fluorofenilhalidom uz prisutnost baze, liganda koji stvara prstenastu strukturu i katalitičkih količina bakrene soli koja sadrži bakar(I) ili bakar(II) te aniona koji ne interferira nepovoljno s reakcijom. Patent sadrži još 11 patentnih zahtjeva.A process for the preparation of sertindole, which comprises the preparation of 5-chloro-1- (4-fluorophenyl) -indole and its conversion to sertindole, wherein the method of preparing 5-chloro-1- (4-fluorophenyl) -indole comprises a reaction to 5-chloro- indole with 4-fluorophenyl halide in the presence of a base, a ring-forming ligand and catalytic amounts of a copper salt containing copper (I) or copper (II) and an anion which does not interfere unfavorably with the reaction. The patent contains 11 more claims.

HR20070120A 2007-03-23 2007-03-23 Method for manufacture of sertindole HRPK20070120B3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HR20070120A HRPK20070120B3 (en) 2007-03-23 2007-03-23 Method for manufacture of sertindole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20070120A HRPK20070120B3 (en) 2007-03-23 2007-03-23 Method for manufacture of sertindole

Publications (2)

Publication Number Publication Date
HRP20070120A2 HRP20070120A2 (en) 2008-10-31
HRPK20070120B3 true HRPK20070120B3 (en) 2009-09-30

Family

ID=39876485

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20070120A HRPK20070120B3 (en) 2007-03-23 2007-03-23 Method for manufacture of sertindole

Country Status (1)

Country Link
HR (1) HRPK20070120B3 (en)

Also Published As

Publication number Publication date
HRP20070120A2 (en) 2008-10-31

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