EA200401006A1 - Аэрозольные препараты для внутрилёгочного введения лекарств с получением системного действия - Google Patents

Аэрозольные препараты для внутрилёгочного введения лекарств с получением системного действия

Info

Publication number
EA200401006A1
EA200401006A1 EA200401006A EA200401006A EA200401006A1 EA 200401006 A1 EA200401006 A1 EA 200401006A1 EA 200401006 A EA200401006 A EA 200401006A EA 200401006 A EA200401006 A EA 200401006A EA 200401006 A1 EA200401006 A1 EA 200401006A1
Authority
EA
Eurasian Patent Office
Prior art keywords
intrainousic
drugs
introduction
systemic action
aerosol preparations
Prior art date
Application number
EA200401006A
Other languages
English (en)
Other versions
EA008571B1 (ru
Inventor
Ребекка Джейн Дейвис
Дейвид Гэндертон
Дейвид Эндрю Льюис
Брайан Джон Микин
Гаэтано Брамбилла
Алессандра Феррарис
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Publication of EA200401006A1 publication Critical patent/EA200401006A1/ru
Publication of EA008571B1 publication Critical patent/EA008571B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В данном изобретении раскрыта аэрозольная фармацевтическая композиция, содержащая лекарство в растворе смеси гидрофторалканового пропеллента и одного или более чем одного сорастворителя, где капельки жидкости аэрозоля, выпускаемые при приведении в действие ингалятора, имеют размер частиц между 0,5 и 2,5 мкм со средним массовым аэродинамическим диаметром приблизительно 1-2 мкм и где фракция мелких частиц составляет по меньшей мере 30%.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401006A 2002-03-01 2003-02-26 Аэрозольные препараты для внутрилегочного введения лекарств с получением системного действия EA008571B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02004786A EP1340492A1 (en) 2002-03-01 2002-03-01 Aerosol formulations for pulmonary administration of medicaments having systemic effects
PCT/EP2003/001962 WO2003074023A1 (en) 2002-03-01 2003-02-26 Aerosol formulations for pulmonary administration of medicaments to produce a systemic effect

Publications (2)

Publication Number Publication Date
EA200401006A1 true EA200401006A1 (ru) 2005-04-28
EA008571B1 EA008571B1 (ru) 2007-06-29

Family

ID=27675679

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401006A EA008571B1 (ru) 2002-03-01 2003-02-26 Аэрозольные препараты для внутрилегочного введения лекарств с получением системного действия

Country Status (27)

Country Link
US (1) US20050129621A1 (ru)
EP (2) EP1340492A1 (ru)
JP (1) JP2005519094A (ru)
KR (1) KR20040091050A (ru)
CN (2) CN1638731A (ru)
AR (2) AR038643A1 (ru)
AT (1) ATE488224T1 (ru)
AU (1) AU2003215597B2 (ru)
BR (1) BR0303348A (ru)
CA (1) CA2477879C (ru)
DE (1) DE60334973D1 (ru)
EA (1) EA008571B1 (ru)
ES (1) ES2358293T3 (ru)
GE (1) GEP20063985B (ru)
HR (1) HRP20040751A2 (ru)
IL (1) IL163842A0 (ru)
MA (1) MA27107A1 (ru)
MX (1) MXPA04008370A (ru)
NO (1) NO20034874L (ru)
NZ (1) NZ535019A (ru)
PE (1) PE20030949A1 (ru)
PL (1) PL372261A1 (ru)
TN (1) TNSN04148A1 (ru)
TW (1) TW200304833A (ru)
UA (2) UA81238C2 (ru)
WO (1) WO2003074023A1 (ru)
ZA (3) ZA200406917B (ru)

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US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
US20060257324A1 (en) * 2000-05-22 2006-11-16 Chiesi Farmaceutici S.P.A. Pharmaceutical solution formulations for pressurised metered dose inhalers
CZ303833B6 (cs) * 2000-05-22 2013-05-22 Chiesi Farmaceutici S.P.A. Aerosolový prostredek
DE60103527T2 (de) * 2001-07-02 2005-06-16 Chiesi Farmaceutici S.P.A. Optimierte Tobramycin-Formulierung zur Aerosolbildung
EP1415647A1 (en) * 2002-10-23 2004-05-06 CHIESI FARMACEUTICI S.p.A. "Long-acting beta-2 agonists ultrafine formulations"
MXPA04008372A (es) * 2002-03-01 2004-11-26 Chiesi Farma Spa Formulacion superfina de formoterol.
EP1452179A1 (en) * 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid
GB0311701D0 (en) * 2003-05-21 2003-06-25 Karib Kemi Pharm Liited Improved metered dose inhaler product
WO2005025550A1 (en) * 2003-09-15 2005-03-24 Vectura Limited Pharmaceutical compositions for treating premature ejaculation by pulmonary inhalation
IL177103A0 (en) * 2004-02-27 2006-12-10 Chiesi Farma Spa Stable pharmaceutical solution formulations for pressurized metered dose inhalers
EP1595531A1 (en) * 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
JP5209963B2 (ja) * 2004-07-02 2013-06-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 噴霧剤としてｔｇ２２７ｅａ又はｔｇ１３４ａを含有するエアロゾル懸濁製剤
RU2457832C2 (ru) * 2005-09-25 2012-08-10 Сипла Лимитед Состав на основе тровентола
WO2007076053A2 (en) * 2005-12-21 2007-07-05 Nitrox, Llc Stable s-nitrosothiol formulations
DE102006017320A1 (de) * 2006-04-11 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel
EP2011534A1 (en) * 2007-07-03 2009-01-07 CHIESI FARMACEUTICI S.p.A. Metered dose inhaler actuator
PE20090907A1 (es) * 2007-07-21 2009-08-05 Boehringer Ingelheim Int Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente
EP2211956A4 (en) 2007-10-10 2014-07-09 Parion Sciences Inc DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
EP2593110B1 (en) * 2010-07-12 2021-01-06 Xellia Pharmaceuticals ApS Treatment of lung infections by administration of tobramycin by aerolisation
EP2619238B1 (en) 2010-09-22 2017-03-08 The Board of Regents of the University of Texas System Novel block copolymer and micelle compositions and methods of use thereof
AU2012267938B2 (en) 2011-06-07 2017-05-04 Parion Sciences, Inc. Methods of treatment
US8945605B2 (en) * 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
WO2013096560A1 (en) * 2011-12-20 2013-06-27 Map Pharmaceuticals, Inc. Excipient-free aerosol formulation
GB201402513D0 (en) * 2014-02-13 2014-04-02 Cardiff Scintigraphics Ltd Pressurised metered dose inhalers and method of manufacture
US10610512B2 (en) 2014-06-26 2020-04-07 Island Breeze Systems Ca, Llc MDI related products and methods of use
EP3297710A4 (en) * 2015-05-21 2019-05-01 Island Breeze Systems Ca, LLC DRILL-BASED INGREDIENTS WITH APPROPRIATE DOSE AND FOOD APPLICATORS AND APPLICATORS
US11129848B2 (en) 2017-08-08 2021-09-28 Perricone Hydrogen Water Company, Llc Medication enhancement using hydrogen
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IES80485B2 (en) * 1996-12-04 1998-08-12 Bioglan Ireland R & D Ltd Pharmaceutical compositions and devices for their administration
GB2326334A (en) * 1997-06-13 1998-12-23 Chiesi Farma Spa Pharmaceutical aerosol compositions
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6284282B1 (en) * 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
EP1143930B8 (en) * 1999-09-11 2008-03-19 Glaxo Group Limited Pharmaceutical formulation of fluticasone propionate
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
IT1317846B1 (it) * 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
ES2280343T3 (es) * 2000-03-09 2007-09-16 Gw Pharma Limited Composiciones farmaceuticas que contienen cannabis.
BR0005797A (pt) * 2000-03-20 2001-10-16 Abbott Lab Métodos para o tratamento de disfunção sexual com apomorfina em nìveis de concentração plasmática especificados
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
CZ303833B6 (cs) * 2000-05-22 2013-05-22 Chiesi Farmaceutici S.P.A. Aerosolový prostredek
MXPA04008372A (es) * 2002-03-01 2004-11-26 Chiesi Farma Spa Formulacion superfina de formoterol.
EP1595531A1 (en) * 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers

Also Published As

Publication number Publication date
NO20034874D0 (no) 2003-10-31
EP1480616B1 (en) 2010-11-17
DE60334973D1 (de) 2010-12-30
AR038643A1 (es) 2005-01-19
TNSN04148A1 (en) 2007-03-12
ZA200406917B (en) 2006-06-28
AR101593A2 (es) 2016-12-28
IL163842A0 (en) 2005-12-18
PE20030949A1 (es) 2004-01-02
ZA200406918B (en) 2006-06-28
MXPA04008370A (es) 2004-11-26
ZA200406919B (en) 2006-06-28
NZ535019A (en) 2006-09-29
PL372261A1 (en) 2005-07-11
ATE488224T1 (de) 2010-12-15
EP1480616A1 (en) 2004-12-01
CA2477879C (en) 2011-05-03
GEP20063985B (en) 2006-12-11
EA008571B1 (ru) 2007-06-29
AU2003215597A1 (en) 2003-09-16
US20050129621A1 (en) 2005-06-16
UA81238C2 (en) 2007-12-25
EP1340492A1 (en) 2003-09-03
CN1638731A (zh) 2005-07-13
HRP20040751A2 (en) 2004-12-31
TW200304833A (en) 2003-10-16
AU2003215597B2 (en) 2008-07-31
BR0303348A (pt) 2004-07-13
CN101502500A (zh) 2009-08-12
JP2005519094A (ja) 2005-06-30
UA80695C2 (en) 2007-10-25
NO20034874L (no) 2003-12-23
MA27107A1 (fr) 2004-12-20
WO2003074023A1 (en) 2003-09-12
KR20040091050A (ko) 2004-10-27
CA2477879A1 (en) 2003-09-12
ES2358293T3 (es) 2011-05-09

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU