EA200400897A1 - Иммуногенные композиции из вариабельных пептидных эпитопов и способ их получения - Google Patents

Иммуногенные композиции из вариабельных пептидных эпитопов и способ их получения

Info

Publication number
EA200400897A1
EA200400897A1 EA200400897A EA200400897A EA200400897A1 EA 200400897 A1 EA200400897 A1 EA 200400897A1 EA 200400897 A EA200400897 A EA 200400897A EA 200400897 A EA200400897 A EA 200400897A EA 200400897 A1 EA200400897 A1 EA 200400897A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hes
immunogenous
reception
compositions
peptide epitopes
Prior art date
Application number
EA200400897A
Other languages
English (en)
Other versions
EA008143B1 (ru
Inventor
Хозе В. Торрес
Original Assignee
Вариейшн Байотекнолоджиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вариейшн Байотекнолоджиз, Инк. filed Critical Вариейшн Байотекнолоджиз, Инк.
Publication of EA200400897A1 publication Critical patent/EA200400897A1/ru
Publication of EA008143B1 publication Critical patent/EA008143B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Описан способ получения иммуногенной пептидной смеси в одном синтезе. Пептидная смесь совокупно представляет вариабельность, наблюдаемую in vivo в иммуногенных эпитопах патогена. Такую смесь называют гипервариабельным эпитопным комплексом (ГЭК). Иммунизация ГЭК вызывает широкореактивную иммунность против дивергентных линий патогена, на основе которого создан ГЭК.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400897A 2002-02-08 2002-02-08 Иммуногенные композиции из вариабельных пептидных эпитопов и способ их получения EA008143B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2002/000137 WO2003066090A1 (en) 2002-02-08 2002-02-08 Immunogenic formulations of variable peptidic epitopes and process for preparation thereof

Publications (2)

Publication Number Publication Date
EA200400897A1 true EA200400897A1 (ru) 2005-04-28
EA008143B1 EA008143B1 (ru) 2007-04-27

Family

ID=27671946

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400897A EA008143B1 (ru) 2002-02-08 2002-02-08 Иммуногенные композиции из вариабельных пептидных эпитопов и способ их получения

Country Status (10)

Country Link
EP (1) EP1476182B1 (ru)
JP (1) JP4391827B2 (ru)
CN (1) CN1625409B (ru)
AP (1) AP2393A (ru)
AT (1) ATE533113T1 (ru)
AU (1) AU2002231510B2 (ru)
CA (1) CA2472265C (ru)
EA (1) EA008143B1 (ru)
MX (1) MXPA04007646A (ru)
WO (1) WO2003066090A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2237065C2 (ru) * 2002-10-03 2004-09-27 Государственный научный центр вирусологии и биотехнологии "Вектор" Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека
KR20080027777A (ko) * 2005-06-01 2008-03-28 배리에이션 바이오테크놀로지스 아이엔씨. 펩티드­기초 인플루엔자 백신 제제
JP5177451B2 (ja) * 2006-11-30 2013-04-03 ヴァリエーション バイオテクノロジーズ インコーポレイテッド インフルエンザワクチン製剤
JP5775451B2 (ja) 2008-06-19 2015-09-09 バリエーション バイオテクノロジーズ インコーポレイティド インフルエンザを処置するための組成物および方法
AU2010226490A1 (en) * 2009-03-20 2011-10-06 Amgen Inc. Inhibitors of PI3 kinase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT728015E (pt) * 1992-06-18 2006-07-31 Creagen Inc Antigenes polipeptidicos combinatoriais

Also Published As

Publication number Publication date
EP1476182A1 (en) 2004-11-17
JP4391827B2 (ja) 2009-12-24
CA2472265C (en) 2013-02-05
AP2393A (en) 2012-04-04
CA2472265A1 (en) 2003-08-14
MXPA04007646A (es) 2005-05-27
CN1625409B (zh) 2010-07-28
AU2002231510B2 (en) 2008-04-03
AP2004003081A0 (en) 2004-09-30
CN1625409A (zh) 2005-06-08
EP1476182B1 (en) 2011-11-09
ATE533113T1 (de) 2011-11-15
EA008143B1 (ru) 2007-04-27
AU2002231510A1 (en) 2003-09-02
WO2003066090A1 (en) 2003-08-14
JP2005531499A (ja) 2005-10-20

Similar Documents

Publication Publication Date Title
CY1119106T1 (el) Αντισωματα εναντι masp-2
MX338940B (es) Identificacion de epitopos ige novedosos.
EA200501286A1 (ru) МОЛЕКУЛЫ АНТИТЕЛ СО СПЕЦИФИЧНОСТЬЮ К ЧЕЛОВЕЧЕСКОМУ IL-1β
EA200800812A1 (ru) Композиции антитела против cd3
WO2004022709A3 (en) Epitope sequences
WO2002081646A3 (en) Epitope sequences
DE69526339T2 (de) Monoklonale antikörper, die an den vorläufer des tumorabstossantigen mage-1 anbinden, rekombinantes mage-1, und von mage-1 abgebieteteimmunogene peptide
CO6231038A2 (es) Proteinas de union, incluyendo anticuerpos derivados de anticuerpo y fragmentos de anticuerpo que se unen especificamente a cd154 y sus usos
LT2990422T (lt) Humanizuoti anti-beta7 antagonistai ir jų panaudojimas
MXPA04001224A (es) Agentes para incrementar la respuesta inmune.
JO3000B1 (ar) مركبات أجسام مضادة .
EP2292271A3 (en) Remodelling and glycoconjugation of an antibody
CY1115311T1 (el) Hla-a2 ογκοσχετιζομενα αντιγονικα πεπτιδια και συνθεσεις
RS54111B1 (en) ANTI-ALPHA 2 INTEGRIN ANTIBODIES AND THEIR USES
ATE465181T1 (de) Humanisierte anti-cmet-antagonisten
BRPI0412245A (pt) anticorpos de rg1 e usos destes
EA200401551A1 (ru) Получение сульфинилацетамида
EA200201138A1 (ru) Пептид, модулирующий рецептор тромбопоэтина
EA200600646A1 (ru) Способы, наборы и композиции для разработки и применения моноклональных антител, специфичных к антигенам с низкой иммуногенностью
TW200517121A (en) Immunogen
BR0211761A (pt) depsipeptìdeos e processos para preparar os mesmos
EA200400897A1 (ru) Иммуногенные композиции из вариабельных пептидных эпитопов и способ их получения
PH12021550441A1 (en) Modified pedv spike protein
AU2003262810A8 (en) Epha2 antigen t epitopes
DE60216906D1 (de) Anti-pilyrosporum ovale igy und dessen verwendung

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU