EA200400668A1 - Фармацевтическая композиция на основе микронизированного прогестерона, способ её получения и её применение - Google Patents

Фармацевтическая композиция на основе микронизированного прогестерона, способ её получения и её применение

Info

Publication number
EA200400668A1
EA200400668A1 EA200400668A EA200400668A EA200400668A1 EA 200400668 A1 EA200400668 A1 EA 200400668A1 EA 200400668 A EA200400668 A EA 200400668A EA 200400668 A EA200400668 A EA 200400668A EA 200400668 A1 EA200400668 A1 EA 200400668A1
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
pharmaceutical composition
application
micronized progesterone
composition based
Prior art date
Application number
EA200400668A
Other languages
English (en)
Other versions
EA006550B1 (ru
Inventor
Антуан Безенс
Жером Бесс
Original Assignee
Безенс Интернэшнл Бельжик
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Безенс Интернэшнл Бельжик filed Critical Безенс Интернэшнл Бельжик
Publication of EA200400668A1 publication Critical patent/EA200400668A1/ru
Publication of EA006550B1 publication Critical patent/EA006550B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Настоящее изобретение касается фармацевтической композиции, включающей микронизированный прогестерон, соевый лецитин и по меньшей мере одно масло, выбранное из группы, состоящей из подсолнечного, оливкового, кунжутного, рапсового и миндального масла, способа ее получения и ее применения для лечения физиологических нарушений, связанных с недостаточностью секреции прогестерона.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400668A 2001-11-13 2002-11-13 Фармацевтическая композиция на основе микронизированного прогестерона, способ её получения и её применение EA006550B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0114653A FR2832065B1 (fr) 2001-11-13 2001-11-13 Composition pharmaceutique a base de progesterone micronisee son procede de preparation et ses utilisations
PCT/FR2002/003879 WO2003041720A1 (fr) 2001-11-13 2002-11-13 Composition pharmaceutique a base de progesterone micronisee, son procede de preparation et ses utilisations

Publications (2)

Publication Number Publication Date
EA200400668A1 true EA200400668A1 (ru) 2004-10-28
EA006550B1 EA006550B1 (ru) 2006-02-24

Family

ID=8869332

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400668A EA006550B1 (ru) 2001-11-13 2002-11-13 Фармацевтическая композиция на основе микронизированного прогестерона, способ её получения и её применение

Country Status (25)

Country Link
US (5) US20030092691A1 (ru)
EP (1) EP1443940B1 (ru)
KR (1) KR100911790B1 (ru)
CN (1) CN1263453C (ru)
AT (1) ATE339958T1 (ru)
AU (1) AU2002352334B2 (ru)
BR (1) BRPI0214043B8 (ru)
CY (1) CY1106293T1 (ru)
DE (1) DE60214876T2 (ru)
DK (1) DK1443940T3 (ru)
EA (1) EA006550B1 (ru)
ES (1) ES2272793T3 (ru)
FR (1) FR2832065B1 (ru)
HK (1) HK1064606A1 (ru)
HU (1) HU229341B1 (ru)
IL (2) IL161668A0 (ru)
MA (1) MA27081A1 (ru)
NO (1) NO335044B1 (ru)
NZ (1) NZ532659A (ru)
OA (1) OA12726A (ru)
PL (1) PL206096B1 (ru)
PT (1) PT1443940E (ru)
UA (1) UA77451C2 (ru)
WO (1) WO2003041720A1 (ru)
ZA (1) ZA200403288B (ru)

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FR2832065B1 (fr) 2001-11-13 2004-11-05 Besins Int Belgique Composition pharmaceutique a base de progesterone micronisee son procede de preparation et ses utilisations
CA2533013C (en) * 2003-07-17 2011-07-26 Banner Pharmacaps, Inc. Controlled release preparations
EP1893182B8 (en) * 2005-05-26 2012-04-04 Teva Women's Health, Inc. Oral dosage forms comprising progesterone and method of making and using the same
US8828981B2 (en) * 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
AT12800U1 (de) * 2007-11-05 2012-11-15 Bayer Schering Pharma Ag Pharmazeutisches Präparat zur Verwendung bei der oralen Kontrazeption von Frauen mit Laktoseintoleranz
FR2947178B1 (fr) 2009-06-29 2012-07-06 Effik Composition pharmaceutique a base de progesterone micronisee et ses utilisations
CN102091054B (zh) * 2009-12-14 2014-04-16 浙江爱生药业有限公司 黄体酮制剂组合物及其制备方法
US9375437B2 (en) 2010-06-18 2016-06-28 Lipocine Inc. Progesterone containing oral dosage forms and kits
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
JP6290081B2 (ja) * 2011-09-15 2018-03-07 フリウルケム、ソシエタ、ペル、アチオニＦｒｉｕｌｃｈｅｍ Ｓｐａ 動物への経口投与用組成物、その製造方法およびその使用
KR102162901B1 (ko) * 2011-09-29 2020-10-08 피엘엑스 옵코 인코포레이티드 위장관을 따라 약물을 표적화 방출하기 위한 pH 감응성 담체, 그로부터의 조성물, 및 이들의 제조 및 사용 방법
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
HRP20211377T1 (hr) 2011-11-23 2022-01-07 Therapeuticsmd, Inc. Prirodne kombinirane hormonske supstitucijske formulacije i terapije
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CA2947767A1 (en) 2014-05-22 2015-11-26 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CA2951284A1 (en) 2014-07-29 2016-02-04 Therapeuticsmd, Inc. Transdermal cream
EP3310359A4 (en) 2015-06-22 2019-04-03 Lipocine Inc. ORAL COMPOSITIONS CONTAINING 17-HYDROXYPROGESTERONE ESTER AND METHODS RELATING THERETO
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
JP2019513709A (ja) 2016-04-01 2019-05-30 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． ステロイドホルモン薬学的組成物
EP3395332A1 (en) 2017-04-28 2018-10-31 Chemo Research, S.L. Hormone softgel capsules and a process for the preparation thereof
US10285998B1 (en) 2018-04-04 2019-05-14 The Menopause Method, Inc. Composition and method to aid in hormone replacement therapy
US11576920B2 (en) 2019-03-18 2023-02-14 The Menopause Method, Inc. Composition and method to aid in hormone replacement therapy
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
AU2021244695A1 (en) 2020-03-26 2022-11-10 Plx Opco Inc. Pharmaceutical carriers capable of pH dependent reconstitution and methods for making and using same

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IT1256386B (it) * 1992-11-13 1995-12-04 Luigi Boltri Composizioni farmaceutiche comprendenti un farmaco,una sostanza polimerica reticolata,un olio ed un agente tensioattivo
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FR2747042B1 (fr) * 1996-04-05 1998-06-05 Besins Iscovesco Lab Medicament a base de progesterone et d'oestradiol
GB9608719D0 (en) * 1996-04-26 1996-07-03 Scherer Ltd R P Pharmaceutical compositions
CA2668824A1 (en) * 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secre Tary Of The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
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Also Published As

Publication number Publication date
CN1585644A (zh) 2005-02-23
KR20050058231A (ko) 2005-06-16
BR0214043A (pt) 2004-10-13
US20110135719A1 (en) 2011-06-09
CY1106293T1 (el) 2011-10-12
UA77451C2 (en) 2006-12-15
IL161668A (en) 2009-09-01
ZA200403288B (en) 2005-07-27
EP1443940B1 (fr) 2006-09-20
BRPI0214043B1 (pt) 2019-12-31
WO2003041720A1 (fr) 2003-05-22
US20120276194A1 (en) 2012-11-01
ATE339958T1 (de) 2006-10-15
NZ532659A (en) 2006-04-28
PL369131A1 (en) 2005-04-18
OA12726A (en) 2006-06-27
HUP0401935A2 (hu) 2005-01-28
NO20042002L (no) 2004-05-14
KR100911790B1 (ko) 2009-08-12
US8435561B2 (en) 2013-05-07
EP1443940A1 (fr) 2004-08-11
AU2002352334B2 (en) 2008-10-23
PL206096B1 (pl) 2010-06-30
US20030092691A1 (en) 2003-05-15
FR2832065A1 (fr) 2003-05-16
DE60214876T2 (de) 2007-04-05
HU229341B1 (en) 2013-11-28
ES2272793T3 (es) 2007-05-01
IL161668A0 (en) 2004-09-27
NO335044B1 (no) 2014-09-01
BRPI0214043B8 (pt) 2021-05-25
US7829115B2 (en) 2010-11-09
US20050004076A1 (en) 2005-01-06
US7431941B2 (en) 2008-10-07
CN1263453C (zh) 2006-07-12
EA006550B1 (ru) 2006-02-24
US20090123534A1 (en) 2009-05-14
MA27081A1 (fr) 2004-12-20
FR2832065B1 (fr) 2004-11-05
PT1443940E (pt) 2007-01-31
HK1064606A1 (ru) 2005-02-04
HUP0401935A3 (en) 2011-02-28
DE60214876D1 (de) 2006-11-02
DK1443940T3 (da) 2007-01-29

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