CY1106293T1 - Φαρμακευτικη συνθεση που βασιζεται επι μικροϊονισθεισης προγεστepονης, η μεθοδος παρασκευης αυτης και οι χρησιμοποιησεις αυτης - Google Patents

Φαρμακευτικη συνθεση που βασιζεται επι μικροϊονισθεισης προγεστepονης, η μεθοδος παρασκευης αυτης και οι χρησιμοποιησεις αυτης

Info

Publication number
CY1106293T1
CY1106293T1 CY20061101808T CY061101808T CY1106293T1 CY 1106293 T1 CY1106293 T1 CY 1106293T1 CY 20061101808 T CY20061101808 T CY 20061101808T CY 061101808 T CY061101808 T CY 061101808T CY 1106293 T1 CY1106293 T1 CY 1106293T1
Authority
CY
Cyprus
Prior art keywords
oil
preparation
pharmaceutical composition
progestepone
micronization
Prior art date
Application number
CY20061101808T
Other languages
English (en)
Inventor
Antoine Besins
Jerome Besse
Original Assignee
Besins International Belgique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Besins International Belgique filed Critical Besins International Belgique
Publication of CY1106293T1 publication Critical patent/CY1106293T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά φαρμακευτική σύνθεση που περιέχει μικροϊονισθείσα προγεστερόνη, λεκιθίνη σόγιας, και τουλάχιστον ένα έλαιο που εκλέγεται από την ομάδα που αποτελείται από ηλιέλαιο, ελαιόλαδο, σησαμέλαιο, κραμβέλαιο και αμυγδαλέλαιο, την μέθοδο παρασκευής αυτής και τις χρησιμοποιήσεις αυτής δια την θεραπευτική αγωγή φυσιολογικής καταστάσεως που συνδυάζεται με την ανεπάρκεια της εκκρίσεως προγεστερόνης.
CY20061101808T 2001-11-13 2006-12-18 Φαρμακευτικη συνθεση που βασιζεται επι μικροϊονισθεισης προγεστepονης, η μεθοδος παρασκευης αυτης και οι χρησιμοποιησεις αυτης CY1106293T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0114653A FR2832065B1 (fr) 2001-11-13 2001-11-13 Composition pharmaceutique a base de progesterone micronisee son procede de preparation et ses utilisations
PCT/FR2002/003879 WO2003041720A1 (fr) 2001-11-13 2002-11-13 Composition pharmaceutique a base de progesterone micronisee, son procede de preparation et ses utilisations

Publications (1)

Publication Number Publication Date
CY1106293T1 true CY1106293T1 (el) 2011-10-12

Family

ID=8869332

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101808T CY1106293T1 (el) 2001-11-13 2006-12-18 Φαρμακευτικη συνθεση που βασιζεται επι μικροϊονισθεισης προγεστepονης, η μεθοδος παρασκευης αυτης και οι χρησιμοποιησεις αυτης

Country Status (25)

Country Link
US (5) US20030092691A1 (el)
EP (1) EP1443940B1 (el)
KR (1) KR100911790B1 (el)
CN (1) CN1263453C (el)
AT (1) ATE339958T1 (el)
AU (1) AU2002352334B2 (el)
BR (1) BRPI0214043B8 (el)
CY (1) CY1106293T1 (el)
DE (1) DE60214876T2 (el)
DK (1) DK1443940T3 (el)
EA (1) EA006550B1 (el)
ES (1) ES2272793T3 (el)
FR (1) FR2832065B1 (el)
HK (1) HK1064606A1 (el)
HU (1) HU229341B1 (el)
IL (2) IL161668A0 (el)
MA (1) MA27081A1 (el)
NO (1) NO335044B1 (el)
NZ (1) NZ532659A (el)
OA (1) OA12726A (el)
PL (1) PL206096B1 (el)
PT (1) PT1443940E (el)
UA (1) UA77451C2 (el)
WO (1) WO2003041720A1 (el)
ZA (1) ZA200403288B (el)

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FR2832065B1 (fr) 2001-11-13 2004-11-05 Besins Int Belgique Composition pharmaceutique a base de progesterone micronisee son procede de preparation et ses utilisations
PT2279729T (pt) * 2003-07-17 2016-09-22 Banner Life Sciences Llc Preparações de libertação controlada
ATE543489T1 (de) * 2005-05-26 2012-02-15 Teva Womens Health Inc Orale dosierformen mit progesteron und verwendungs- und herstellungsverfahren dafür
US8828981B2 (en) 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
DE202007019049U1 (de) * 2007-11-05 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Verwendung eines Gestagens in Kombination mit einem Estrogen zur Prophylaxe der Laktoseintoleranz bei der oralen Kontrazeption
FR2947178B1 (fr) 2009-06-29 2012-07-06 Effik Composition pharmaceutique a base de progesterone micronisee et ses utilisations
CN102091054B (zh) * 2009-12-14 2014-04-16 浙江爱生药业有限公司 黄体酮制剂组合物及其制备方法
US9375437B2 (en) 2010-06-18 2016-06-28 Lipocine Inc. Progesterone containing oral dosage forms and kits
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
WO2013037650A1 (fr) * 2011-09-15 2013-03-21 Friulchem Spa Compositions pour administration orale aux animaux, leurs procedes d'obtention et leurs utilisations
CA2850187C (en) * 2011-09-29 2021-12-07 Plx Pharma Inc. Ph dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same
LT2782584T (lt) 2011-11-23 2021-09-10 Therapeuticsmd, Inc. Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
AU2015296609A1 (en) 2014-07-29 2016-12-22 Therapeuticsmd, Inc. Transdermal cream
MX2017016823A (es) 2015-06-22 2018-03-12 Lipocine Inc Composiciones orales que contienen éster de 17- hydroxiprogesterona y métodos relacionados.
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
EP3395332A1 (en) 2017-04-28 2018-10-31 Chemo Research, S.L. Hormone softgel capsules and a process for the preparation thereof
US10285998B1 (en) 2018-04-04 2019-05-14 The Menopause Method, Inc. Composition and method to aid in hormone replacement therapy
US11576920B2 (en) 2019-03-18 2023-02-14 The Menopause Method, Inc. Composition and method to aid in hormone replacement therapy
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
MX2022011743A (es) 2020-03-26 2022-12-08 Plx Opco Inc Portadores farmaceuticos con capacidad de reconstitucion dependiente del ph y metodos para elaborar y usar los mismos.
EP4389117A1 (en) 2022-12-19 2024-06-26 Besins Healthcare Distribution FZ-LLC Progesterone formulation

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FR2408345A1 (fr) * 1976-11-30 1979-06-08 Besins Jean Louis Nouvelle composition a action anti-conceptionnelle
JPS60258110A (ja) * 1984-06-05 1985-12-20 Daigo Eiyou Kagaku Kk 静脈注射可能なプロゲステロン乳化注射液
US5140021A (en) * 1986-04-16 1992-08-18 Genesis Systems Corporation Method and dosage form for treatment of premenstrual syndrome
IE61236B1 (en) * 1986-07-15 1994-10-19 American Home Prod Combination dosage form for pre-menopausal women
IT1256386B (it) * 1992-11-13 1995-12-04 Luigi Boltri Composizioni farmaceutiche comprendenti un farmaco,una sostanza polimerica reticolata,un olio ed un agente tensioattivo
EP0664112B1 (fr) * 1993-12-22 1997-03-26 L'oreal Poudre cosmétique ou dermatologique, son procédé de préparation et utilisations
FR2747042B1 (fr) * 1996-04-05 1998-06-05 Besins Iscovesco Lab Medicament a base de progesterone et d'oestradiol
GB9608719D0 (en) * 1996-04-26 1996-07-03 Scherer Ltd R P Pharmaceutical compositions
CA2253673C (en) * 1996-05-01 2009-09-08 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
FR2777784B1 (fr) * 1998-04-27 2004-03-19 Arepa Composition pharmaceutique a base d'estrogene et de progesterone
FR2832065B1 (fr) * 2001-11-13 2004-11-05 Besins Int Belgique Composition pharmaceutique a base de progesterone micronisee son procede de preparation et ses utilisations

Also Published As

Publication number Publication date
US7431941B2 (en) 2008-10-07
US20050004076A1 (en) 2005-01-06
ES2272793T3 (es) 2007-05-01
WO2003041720A1 (fr) 2003-05-22
FR2832065A1 (fr) 2003-05-16
DK1443940T3 (da) 2007-01-29
KR100911790B1 (ko) 2009-08-12
BRPI0214043B8 (pt) 2021-05-25
UA77451C2 (en) 2006-12-15
KR20050058231A (ko) 2005-06-16
IL161668A (en) 2009-09-01
OA12726A (en) 2006-06-27
HK1064606A1 (el) 2005-02-04
US20030092691A1 (en) 2003-05-15
CN1263453C (zh) 2006-07-12
BR0214043A (pt) 2004-10-13
EA006550B1 (ru) 2006-02-24
US8435561B2 (en) 2013-05-07
US20090123534A1 (en) 2009-05-14
NZ532659A (en) 2006-04-28
AU2002352334B2 (en) 2008-10-23
ZA200403288B (en) 2005-07-27
DE60214876D1 (de) 2006-11-02
EA200400668A1 (ru) 2004-10-28
NO20042002L (no) 2004-05-14
PL369131A1 (en) 2005-04-18
EP1443940B1 (fr) 2006-09-20
DE60214876T2 (de) 2007-04-05
HUP0401935A2 (hu) 2005-01-28
HUP0401935A3 (en) 2011-02-28
PL206096B1 (pl) 2010-06-30
FR2832065B1 (fr) 2004-11-05
HU229341B1 (en) 2013-11-28
US20120276194A1 (en) 2012-11-01
CN1585644A (zh) 2005-02-23
IL161668A0 (en) 2004-09-27
US20110135719A1 (en) 2011-06-09
PT1443940E (pt) 2007-01-31
US7829115B2 (en) 2010-11-09
MA27081A1 (fr) 2004-12-20
NO335044B1 (no) 2014-09-01
EP1443940A1 (fr) 2004-08-11
BRPI0214043B1 (pt) 2019-12-31
ATE339958T1 (de) 2006-10-15

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