EA200200591A1 - ПИРРОЛИДИНЫ, КОТОРЫЕ ИНГИБИРУЮТ цАМФ-СПЕЦИФИЧНУЮ PDE - Google Patents
ПИРРОЛИДИНЫ, КОТОРЫЕ ИНГИБИРУЮТ цАМФ-СПЕЦИФИЧНУЮ PDEInfo
- Publication number
- EA200200591A1 EA200200591A1 EA200200591A EA200200591A EA200200591A1 EA 200200591 A1 EA200200591 A1 EA 200200591A1 EA 200200591 A EA200200591 A EA 200200591A EA 200200591 A EA200200591 A EA 200200591A EA 200200591 A1 EA200200591 A1 EA 200200591A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrrolidines
- compounds
- specific pde
- inhibit camp
- well
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
Abstract
Описаны новые соединения (II), которые являются сильнодействующими селективными ингибиторами PDE4, а также способы получения соединений. Приведено использование соединений для лечения воспалительных заболеваний и других заболеваний, связанных с повышенными уровнями цитокинов, а также нарушений центральной нервной системы (ЦНС). Значения R-R, Rи Rтакие, как приведены в заявке.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17202399P | 1999-12-23 | 1999-12-23 | |
PCT/US2000/034116 WO2001047879A1 (en) | 1999-12-23 | 2000-12-15 | Pyrrolidines which inhibit camp-specific pde |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200200591A1 true EA200200591A1 (ru) | 2002-12-26 |
EA007589B1 EA007589B1 (ru) | 2006-12-29 |
Family
ID=22626053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200591A EA007589B1 (ru) | 1999-12-23 | 2000-12-15 | ПИРРОЛИДИНЫ, КОТОРЫЕ ИНГИБИРУЮТ цАМФ-СПЕЦИФИЧНУЮ PDE |
Country Status (16)
Country | Link |
---|---|
US (1) | US6376489B1 (ru) |
EP (1) | EP1244619A1 (ru) |
JP (1) | JP2003519122A (ru) |
KR (1) | KR20020063601A (ru) |
CN (1) | CN1246311C (ru) |
AU (1) | AU778795B2 (ru) |
BR (1) | BR0016687A (ru) |
CA (1) | CA2395173A1 (ru) |
EA (1) | EA007589B1 (ru) |
HU (1) | HUP0300169A3 (ru) |
IL (1) | IL150287A0 (ru) |
MX (1) | MXPA02006206A (ru) |
NO (1) | NO20023009L (ru) |
PL (1) | PL355893A1 (ru) |
WO (1) | WO2001047879A1 (ru) |
ZA (1) | ZA200205015B (ru) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6680336B2 (en) * | 1999-12-15 | 2004-01-20 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
US6794192B2 (en) * | 2000-06-29 | 2004-09-21 | Pfizer Inc. | Target |
WO2002022605A1 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6989385B2 (en) | 2000-12-21 | 2006-01-24 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US20050101000A1 (en) * | 2002-12-11 | 2005-05-12 | Isis Pharmaceuticals Inc. | Modulation of phosphodiesterase 4B expression |
EA200500299A1 (ru) | 2002-08-02 | 2005-08-25 | Вертекс Фармасьютикалз Инкорпорейтед | Пиразольные композиции, используемые в качестве ингибиторов gsk-3 |
US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249435A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
KR20090064418A (ko) | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
JO3264B1 (ar) * | 2013-03-13 | 2018-09-16 | Lilly Co Eli | مركبات ازيتيدينيل أوكسي فينيل بيروليدين |
DK3150578T3 (da) * | 2014-05-29 | 2021-01-18 | Mitsubishi Tanabe Pharma Corp | Ny pyrrolidinforbindelse og anvendelse som melanocortin-receptoragonist |
ES2967094T3 (es) | 2017-09-29 | 2024-04-26 | Mitsubishi Tanabe Pharma Corp | Compuesto de pirrolidina ópticamente activo y procedimiento de producción del mismo |
WO2020125627A1 (zh) * | 2018-12-18 | 2020-06-25 | 湖北生物医药产业技术研究院有限公司 | 苯基吡咯烷类化合物及其用途 |
CN113563246A (zh) * | 2020-04-29 | 2021-10-29 | 广东东阳光药业有限公司 | 取代的氮杂五元环类衍生物及其在药物中的应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5821622B2 (ja) | 1973-02-28 | 1983-05-02 | ウェルファイド株式会社 | ピロリジンメタノ−ル ノ セイゾウホウ |
PT100441A (pt) | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
SK279285B6 (sk) * | 1991-05-02 | 1998-09-09 | Daiichi Pharmaceutical Co. | Použitie n-(2,6-dimetylfenyl)-2-(2-oxo-1-pyrolidin |
US5665754A (en) | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
CA2143143A1 (en) | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
DE19601938A1 (de) | 1996-01-12 | 1997-07-17 | Schering Ag | Neue Phosphodiesteraseinhibitoren |
US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
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2000
- 2000-12-07 US US09/731,591 patent/US6376489B1/en not_active Expired - Fee Related
- 2000-12-15 KR KR1020027008161A patent/KR20020063601A/ko not_active Application Discontinuation
- 2000-12-15 MX MXPA02006206A patent/MXPA02006206A/es active IP Right Grant
- 2000-12-15 BR BR0016687-1A patent/BR0016687A/pt not_active Application Discontinuation
- 2000-12-15 CA CA002395173A patent/CA2395173A1/en not_active Abandoned
- 2000-12-15 HU HU0300169A patent/HUP0300169A3/hu unknown
- 2000-12-15 JP JP2001549352A patent/JP2003519122A/ja active Pending
- 2000-12-15 CN CNB008191182A patent/CN1246311C/zh not_active Expired - Fee Related
- 2000-12-15 WO PCT/US2000/034116 patent/WO2001047879A1/en not_active Application Discontinuation
- 2000-12-15 AU AU21065/01A patent/AU778795B2/en not_active Ceased
- 2000-12-15 EA EA200200591A patent/EA007589B1/ru not_active IP Right Cessation
- 2000-12-15 EP EP00984450A patent/EP1244619A1/en not_active Withdrawn
- 2000-12-15 PL PL00355893A patent/PL355893A1/xx not_active Application Discontinuation
- 2000-12-15 IL IL15028700A patent/IL150287A0/xx unknown
-
2002
- 2002-06-21 ZA ZA200205015A patent/ZA200205015B/xx unknown
- 2002-06-21 NO NO20023009A patent/NO20023009L/no unknown
Also Published As
Publication number | Publication date |
---|---|
PL355893A1 (en) | 2004-05-31 |
BR0016687A (pt) | 2003-02-25 |
JP2003519122A (ja) | 2003-06-17 |
CA2395173A1 (en) | 2001-07-05 |
KR20020063601A (ko) | 2002-08-03 |
CN1246311C (zh) | 2006-03-22 |
HUP0300169A3 (en) | 2009-03-30 |
IL150287A0 (en) | 2002-12-01 |
NO20023009D0 (no) | 2002-06-21 |
HUP0300169A2 (en) | 2003-05-28 |
WO2001047879A1 (en) | 2001-07-05 |
EA007589B1 (ru) | 2006-12-29 |
NO20023009L (no) | 2002-08-19 |
US6376489B1 (en) | 2002-04-23 |
MXPA02006206A (es) | 2004-02-26 |
CN1434798A (zh) | 2003-08-06 |
AU778795B2 (en) | 2004-12-23 |
ZA200205015B (en) | 2004-04-08 |
EP1244619A1 (en) | 2002-10-02 |
AU2106501A (en) | 2001-07-09 |
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