EA200200451A1 - Комплекс n-формилпептидных рецепторов с агентом модификации пути передачи сигнала с участием g-белок-киназы - Google Patents
Комплекс n-формилпептидных рецепторов с агентом модификации пути передачи сигнала с участием g-белок-киназыInfo
- Publication number
- EA200200451A1 EA200200451A1 EA200200451A EA200200451A EA200200451A1 EA 200200451 A1 EA200200451 A1 EA 200200451A1 EA 200200451 A EA200200451 A EA 200200451A EA 200200451 A EA200200451 A EA 200200451A EA 200200451 A1 EA200200451 A1 EA 200200451A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- agent
- cell
- pro
- complex
- formilpeptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Описан способ ингибирования провоспалительного ответа мононуклеарной клетки или полиморфонуклеарной клетки периферической крови человека или фиксированной клетки ткани. Эту клетку подвергают контакту с провоспалительным агентом для стимуляции провоспалительного ответа. Затем указанную клетку подвергают контакту с агентом модификации пути передачи сигнала с участием G-белок-киназы, ингибируя тем самым пути передачи сигналов воспалительного ответа, опосредованной G-белком. Описан рецепторный комплекс, где агент модификации пути передачи сигнала с участием G-белок-киназы связывается с рецептором поверхности мононуклеарной клетки или полиморфонуклеарной клетки периферической крови человека, стимулированной провоспалительным агентом.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15967799P | 1999-10-15 | 1999-10-15 | |
PCT/US2000/028183 WO2001029069A1 (en) | 1999-10-15 | 2000-10-12 | N-formyl peptide receptor complex with a g-protein kinase signal pathway modification agent |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200200451A1 true EA200200451A1 (ru) | 2002-10-31 |
Family
ID=22573520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200451A EA200200451A1 (ru) | 1999-10-15 | 2000-10-12 | Комплекс n-формилпептидных рецепторов с агентом модификации пути передачи сигнала с участием g-белок-киназы |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1222199A4 (ru) |
JP (1) | JP2004507441A (ru) |
KR (1) | KR20020057972A (ru) |
CN (1) | CN100497374C (ru) |
AU (1) | AU8014200A (ru) |
BR (1) | BR0014742A (ru) |
CA (1) | CA2387559A1 (ru) |
CZ (1) | CZ20021342A3 (ru) |
EA (1) | EA200200451A1 (ru) |
HU (1) | HUP0203688A2 (ru) |
IL (1) | IL149125A0 (ru) |
MX (1) | MXPA02003782A (ru) |
NO (1) | NO20021732L (ru) |
PL (1) | PL356096A1 (ru) |
WO (1) | WO2001029069A1 (ru) |
ZA (1) | ZA200202937B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1138692A1 (en) | 2000-03-29 | 2001-10-04 | Erasmus Universiteit Rotterdam | Fragments of human chorionic gonadotropin (hcg) as immunoregulator |
US8680059B2 (en) | 1998-05-20 | 2014-03-25 | Biotempt B.V. | Oligopeptide acetate and formulations thereof |
US6844315B2 (en) | 1998-05-20 | 2005-01-18 | Erasmus Universiteit Rotterdam | Immunoregulator |
US20030220258A1 (en) | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of ischemic events |
US7358330B2 (en) | 2001-03-29 | 2008-04-15 | Biotempt B.V. | Immunoregulatory compositions |
EP1300418A1 (en) * | 2001-10-04 | 2003-04-09 | Erasmus Universiteit Rotterdam | Gene regulation by oligopeptides |
USRE43279E1 (en) | 2000-03-29 | 2012-03-27 | Biotemp B.V. | Compositions capable of reducing elevated blood urea concentration |
US7786084B2 (en) | 2001-12-21 | 2010-08-31 | Biotempt B.V. | Treatment of burns |
WO2004100978A1 (en) * | 2003-05-13 | 2004-11-25 | Medvet Science Pty. Ltd. | A method of modulating cellular transmigration and agents for use therein |
WO2007004869A2 (en) | 2005-07-05 | 2007-01-11 | Biotempt B.V. | Treatment of tumors |
EP1864692A1 (en) | 2006-06-07 | 2007-12-12 | Biotempt B.V. | Use of peptides for the control of radiation injury |
US20110082091A1 (en) * | 2009-09-28 | 2011-04-07 | Theramab Gmbh | Method for Preclinical Testing of Immunomodulatory Drugs |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69840851D1 (de) * | 1997-11-13 | 2009-07-09 | Mowycal Lending Llc | Kleine peptide und methoden zur behandlung von asthma und entzündungen |
-
2000
- 2000-10-12 CA CA002387559A patent/CA2387559A1/en not_active Abandoned
- 2000-10-12 WO PCT/US2000/028183 patent/WO2001029069A1/en active Application Filing
- 2000-10-12 BR BR0014742-7A patent/BR0014742A/pt not_active IP Right Cessation
- 2000-10-12 MX MXPA02003782A patent/MXPA02003782A/es not_active Application Discontinuation
- 2000-10-12 AU AU80142/00A patent/AU8014200A/en not_active Abandoned
- 2000-10-12 PL PL00356096A patent/PL356096A1/xx not_active Application Discontinuation
- 2000-10-12 HU HU0203688A patent/HUP0203688A2/hu unknown
- 2000-10-12 EP EP00970817A patent/EP1222199A4/en not_active Withdrawn
- 2000-10-12 EA EA200200451A patent/EA200200451A1/ru unknown
- 2000-10-12 CN CNB008156867A patent/CN100497374C/zh not_active Expired - Fee Related
- 2000-10-12 KR KR1020027004714A patent/KR20020057972A/ko not_active Application Discontinuation
- 2000-10-12 JP JP2001531867A patent/JP2004507441A/ja active Pending
- 2000-10-12 CZ CZ20021342A patent/CZ20021342A3/cs unknown
- 2000-10-12 IL IL14912500A patent/IL149125A0/xx unknown
-
2002
- 2002-04-12 NO NO20021732A patent/NO20021732L/no not_active Application Discontinuation
- 2002-04-15 ZA ZA200202937A patent/ZA200202937B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PL356096A1 (en) | 2004-06-14 |
NO20021732L (no) | 2002-06-12 |
JP2004507441A (ja) | 2004-03-11 |
NO20021732D0 (no) | 2002-04-12 |
BR0014742A (pt) | 2002-08-27 |
MXPA02003782A (es) | 2002-12-13 |
WO2001029069A1 (en) | 2001-04-26 |
CA2387559A1 (en) | 2001-04-26 |
ZA200202937B (en) | 2003-09-23 |
IL149125A0 (en) | 2002-11-10 |
CN100497374C (zh) | 2009-06-10 |
EP1222199A1 (en) | 2002-07-17 |
EP1222199A4 (en) | 2003-03-12 |
CN1633447A (zh) | 2005-06-29 |
KR20020057972A (ko) | 2002-07-12 |
AU8014200A (en) | 2001-04-30 |
CZ20021342A3 (cs) | 2003-01-15 |
HUP0203688A2 (hu) | 2003-02-28 |
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