CY1106671T1 - Συσκευη για τη χορηγηση φαρμακων μεσω διαβλεφαρικης ηλεκτροφορησης - Google Patents

Συσκευη για τη χορηγηση φαρμακων μεσω διαβλεφαρικης ηλεκτροφορησης

Info

Publication number
CY1106671T1
CY1106671T1 CY20071100830T CY071100830T CY1106671T1 CY 1106671 T1 CY1106671 T1 CY 1106671T1 CY 20071100830 T CY20071100830 T CY 20071100830T CY 071100830 T CY071100830 T CY 071100830T CY 1106671 T1 CY1106671 T1 CY 1106671T1
Authority
CY
Cyprus
Prior art keywords
intereyle
electrification
drugs
administration
main electrode
Prior art date
Application number
CY20071100830T
Other languages
English (en)
Inventor
Francine Behar
Pierre Roy
Original Assignee
Eyegate Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eyegate Pharma Sa filed Critical Eyegate Pharma Sa
Publication of CY1106671T1 publication Critical patent/CY1106671T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Μια συσκευή για την οφθαλμική εφαρμογή ενός ενεργού χημικού συστατικού (1) η οποία περιλαμβάνει ένα κύριο ηλεκτρόδιο (2) που έχει μια μονωτική στρώση, μια συγκολλητική στρώση κατάλληλη για να συνδέει τη μονωτική στρώση με μια αγώγιμη στρώση, που χαρακτηρίζεται από το ότι το κύριο ηλεκτρόδιο έχει μια ζώνη (21, 22) κατάλληλη για να έρχεται σε επαφή με ένα βλέφαρο.
CY20071100830T 2001-10-12 2007-06-21 Συσκευη για τη χορηγηση φαρμακων μεσω διαβλεφαρικης ηλεκτροφορησης CY1106671T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0113176A FR2830766B1 (fr) 2001-10-12 2001-10-12 Dispositif de delivrance de medicaments par iontophorese transpalpebrale
PCT/FR2002/003472 WO2003030989A2 (fr) 2001-10-12 2002-10-11 Dispositif de delivrance de medicaments par iontophorese transpalpebrale

Publications (1)

Publication Number Publication Date
CY1106671T1 true CY1106671T1 (el) 2012-05-23

Family

ID=8868226

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100830T CY1106671T1 (el) 2001-10-12 2007-06-21 Συσκευη για τη χορηγηση φαρμακων μεσω διαβλεφαρικης ηλεκτροφορησης

Country Status (16)

Country Link
US (3) US7848800B2 (el)
EP (1) EP1434622B1 (el)
JP (1) JP4184275B2 (el)
KR (1) KR20050035158A (el)
AT (1) ATE358510T1 (el)
BR (1) BR0213249A (el)
CA (1) CA2463362C (el)
CY (1) CY1106671T1 (el)
DE (1) DE60219336T2 (el)
DK (1) DK1434622T3 (el)
ES (1) ES2283628T3 (el)
FR (1) FR2830766B1 (el)
IL (1) IL161298A0 (el)
MX (1) MXPA04003438A (el)
PT (1) PT1434622E (el)
WO (1) WO2003030989A2 (el)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20090088721A1 (en) * 2001-04-17 2009-04-02 Eyegate Pharma S.A.S. Enhanced retinal delivery of a nucleic acid through iontophoresis
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
FR2869531B1 (fr) * 2004-04-30 2006-07-14 Optis France Sa Sa Dispositif de iontophorese oculaire diminuant les irritations
KR20080018980A (ko) 2004-04-30 2008-02-29 아이게이트 파르마 에스아에스 자극 감소형의 안구용 이온 영동 장치
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US8246949B2 (en) * 2004-10-27 2012-08-21 Aciont, Inc. Methods and devices for sustained in-vivo release of an active agent
US20070260171A1 (en) * 2005-09-27 2007-11-08 Higuchi John W Intraocular iontophoretic device and associated methods
US8755880B2 (en) 2005-10-24 2014-06-17 Aciont, Inc. Intraocular iontophoretic device and associated methods
US8634907B2 (en) * 2005-10-24 2014-01-21 Aciont, Inc. Intraocular iontophoretic device and associated methods
JP5128932B2 (ja) * 2007-12-28 2013-01-23 日立マクセル株式会社 美容機器
ES2679673T3 (es) 2008-12-31 2018-08-30 Eyegate Pharmaceuticals, Inc. Sistema para iontoforesis ocular con amortiguación
JP2012520685A (ja) 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いたＧＡＴＡ結合タンパク質３（ＧＡＴＡ３）遺伝子発現のＲＮＡ干渉媒介性阻害
WO2010107958A1 (en) 2009-03-19 2010-09-23 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (STAT6) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20120016011A1 (en) 2009-03-19 2012-01-19 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA)
EA201171144A1 (ru) 2009-03-19 2012-04-30 Мерк Шарп Энд Домэ Корп. ОПОСРЕДОВАННОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНА ГОМОЛОГА 1 BTB И CNC, ОСНОВНОГО ФАКТОРА ТРАНСКРИПЦИИ С ЛЕЙЦИНОВОЙ МОЛНИЕЙ 1 (Bach1) С ИСПОЛЬЗОВАНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
US20120004281A1 (en) 2009-03-27 2012-01-05 Merck Sharp & Dohme Corp RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA)
WO2010111464A1 (en) 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP2411517A2 (en) 2009-03-27 2012-02-01 Merck Sharp&Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF THE INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1)GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20120022142A1 (en) 2009-03-27 2012-01-26 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
JP2012521764A (ja) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いた胸腺間質性リンパ球新生因子（ＴＳＬＰ）遺伝子発現のＲＮＡ干渉媒介性阻害
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
JP2011018873A (ja) * 2009-05-22 2011-01-27 Sony Ericsson Mobilecommunications Japan Inc 電磁シールド方法および電磁シールド用フィルム
EP2590669B1 (en) 2010-07-09 2016-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment of a disease associated with retinal degenerative disorder
WO2012018754A2 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP3587574B1 (en) 2010-08-17 2022-03-16 Sirna Therapeutics, Inc. Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
EP2609106A4 (en) 2010-08-26 2014-03-19 Merck Sharp & Dohme RNA INTERFERENCE-MEDIATED INHIBITION OF EXPRESSION OF PHD2 GENE (PROLYL HYDROXYLASE DOMAIN 2) USING SMALL INTERFERING NUCLEIC ACID (PANI)
EP2632472B1 (en) 2010-10-29 2017-12-13 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
CA2892672A1 (en) 2012-12-06 2014-06-12 Merck Sharp & Dohme Corp. Disulfide masked prodrug compositions and methods
EP3677229A1 (en) 2014-05-29 2020-07-08 Glaukos Corporation Implants with controlled drug delivery features
BR112017009054A2 (pt) 2015-01-22 2018-01-30 Eyegate Pharmaceuticals Inc lente de contato para terapia ocular.
US20180125947A1 (en) 2015-05-20 2018-05-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment of retinal detachment
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
JP7003110B2 (ja) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション 生体吸収性眼球薬物送達デバイス
CA3046997A1 (en) 2016-12-13 2018-06-21 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
IT201700014315A1 (it) * 2017-02-09 2018-08-09 Bruno Massimo Cetroni Dispositivo per il trasporto intracellulare in biorisonanza
KR101889357B1 (ko) * 2017-09-20 2018-08-17 (주)휴비딕 눈의 나노 약물 전달용 이온공급 장치

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845757A (en) * 1972-07-12 1974-11-05 Minnesota Mining & Mfg Biomedical monitoring electrode
US4564016A (en) * 1982-05-24 1986-01-14 The Board Of Trustees Of The Leland Stanford Junior University Apparatus for introducing ionized drugs into the posterior segment of the eye and method
US4603076A (en) * 1985-03-04 1986-07-29 Norwood Industries, Inc. Hydrophilic foam
US5320597A (en) * 1991-02-08 1994-06-14 Becton, Dickinson And Company Device and method for renewing electrodes during iontophoresis
US5169384A (en) * 1991-08-16 1992-12-08 Bosniak Stephen L Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue
US5356632A (en) * 1991-09-12 1994-10-18 S.I. Scientific Innovations Ltd. Transdermal drug delivery device
AU652494B2 (en) * 1991-11-15 1994-08-25 Minnesota Mining And Manufacturing Company Solid state conductive polymer compositions, biomedical electrodes containing such compositions, and method of preparing same
US5450845A (en) * 1993-01-11 1995-09-19 Axelgaard; Jens Medical electrode system
US5522864A (en) * 1994-10-25 1996-06-04 Wallace; Larry B. Apparatus and method for ocular treatment
AUPM982694A0 (en) * 1994-12-02 1995-01-05 University Of Queensland, The Iontophoresis method and apparatus
FR2773320B1 (fr) * 1998-01-05 2000-03-03 Optisinvest Dispositif pour le transfert intraoculaire de produits actifs par iontophorese
IL123290A (en) * 1998-02-13 2001-12-23 Hadasit Med Res Service Iontophoretic device
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6277401B1 (en) * 1999-05-07 2001-08-21 U.S. Dermatologics, Inc. Drug delivery device
US6728573B1 (en) * 2000-02-23 2004-04-27 Iomed, Inc. Ocular iontophoretic apparatus handle
US6697668B2 (en) * 2001-01-25 2004-02-24 Iomed, Inc. Ocular iontophoretic device and method for using the same
US6546284B2 (en) * 2001-01-25 2003-04-08 Iomed, Inc. Fluid retention assembly for an iontophoretic delivery device and associated method for preparing the same
US20040106965A1 (en) * 2001-06-29 2004-06-03 Chow Alan Y. Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation
US20030023228A1 (en) * 2001-07-20 2003-01-30 Parkinson Thomas M. Ocular iontophoretic device and method for using the same
US6694193B2 (en) * 2001-09-14 2004-02-17 Koninklijke Philips Electronics N.V. Medical electrode and release liner configurations facilitating packaged electrode characterization

Also Published As

Publication number Publication date
US20110098632A1 (en) 2011-04-28
BR0213249A (pt) 2004-09-28
DE60219336D1 (de) 2007-05-16
WO2003030989A2 (fr) 2003-04-17
CA2463362C (fr) 2011-04-19
US20140323947A1 (en) 2014-10-30
US7848800B2 (en) 2010-12-07
US8771256B2 (en) 2014-07-08
DE60219336T2 (de) 2007-12-20
MXPA04003438A (es) 2005-02-17
ATE358510T1 (de) 2007-04-15
ES2283628T3 (es) 2007-11-01
JP4184275B2 (ja) 2008-11-19
US20040267188A1 (en) 2004-12-30
EP1434622A2 (fr) 2004-07-07
IL161298A0 (en) 2004-09-27
PT1434622E (pt) 2007-07-11
FR2830766B1 (fr) 2004-03-12
CA2463362A1 (fr) 2003-04-17
FR2830766A1 (fr) 2003-04-18
US9192512B2 (en) 2015-11-24
JP2005504612A (ja) 2005-02-17
WO2003030989A3 (fr) 2003-10-30
DK1434622T3 (da) 2007-08-13
EP1434622B1 (fr) 2007-04-04
KR20050035158A (ko) 2005-04-15

Similar Documents

Publication Publication Date Title
CY1106671T1 (el) Συσκευη για τη χορηγηση φαρμακων μεσω διαβλεφαρικης ηλεκτροφορησης
DE602004023300D1 (de) Diamant-mikroelektroden
DK1611860T3 (da) Indretning til denervering af intraossøs nerve
SE0002834D0 (sv) Electrochromic device based on nanochrystalline materials
ATE355530T1 (de) Mikromechanisches bauelement
AR039754A2 (es) Lente electroactiva
ATE232990T1 (de) Elektrochromes element
TR200000511T2 (tr) Elektrikli cihazlar ve bunları imal etmek için bir yöntem.
ATE318116T1 (de) Elektrophysiologische elektrode mit mehreren energieversorgungsleitungen
EP1120838A3 (en) Organic light emitting device and method for mounting
BRPI0413909A (pt) eletrodo biomédico, e, método para preparar um eletrodo biomédico
ATE476696T1 (de) Positionsdetektionseinrichtung
DE60216257D1 (de) Leitfähiger organischer dünnfilm und herstellungsverfahren dafür, elektrode und elektrisches kabel damit
DE60307174D1 (de) Grabenkondensator mit zwei vom Substrat unabhängigen Elektroden
DK1054705T3 (da) Anordning til iontoforetisk indgivelse af lægemidler
ATE125856T1 (de) Elektrisch leitfähiger klebstoff.
EP1530242A3 (en) Semiconductor light emitting device
DE60123052D1 (de) Elektro-adhäsions-vorrichtung
ATE459021T1 (de) Coplanare wellenleiterleitung
ATE386341T1 (de) Elektromechanischer wandler mit mindestens einem piezoelektrischen element
TW200722744A (en) Humidity sensor and its fabricating method
ATE516847T1 (de) Korrosionsschutz bei biomedizinischen elektroden
ATE428178T1 (de) Hochspannungskondensator
ATE249266T1 (de) Defibrillator
ATE324140T1 (de) Implantierbare elektrodenstruktur